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Akademický článek

MicroRNA-124-3p suppresses mouse lip mesenchymal cell proliferation through the regulation of genes associated with cleft lip in the mouse

Autor: Akiko Suzuki, Hiroki Yoshioka, Dima Summakia, Neha G. Desai, Goo Jun, Peilin Jia, David S. Loose, Kenichi Ogata, Mona V. Gajera, Zhongming Zhao, Junichi Iwata

Publikováno v: BMC Genomics, Vol 20, Iss 1, Pp 1-17 (2019)

Abstract Background Cleft lip (CL), one of the most common congenital birth defects, shows considerable geographic and ethnic variation, with contribution of both genetic and environmental factors. Mouse genetic studies have identified several CL-ass

Externí odkaz: https://doaj.org/article/6492c77a65784789a05f3bef466f20ee

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Data from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Autor: Russell R. Broaddus, David M. Gershenson, Andrea Milbourne, Peggy Conrad, Molly S. Daniels, Mary Rubin, Stephanie Boyd-Rogers, Terri Cornelison, Henry Lynch, Lee-may Chen, Mark F. Munsell, Graciela M. Nogueras-Gonzalez, Melinda S. Yates, David S. Loose, Karen H. Lu

Women with Lynch syndrome have a 40% to 60% lifetime risk for developing endometrial cancer, a cancer associated with estrogen imbalance. The molecular basis for endometrial-specific tumorigenesis is unclear. Progestins inhibit estrogen-driven prolif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa6855775018413712ca085d8a1d4aad
https://doi.org/10.1158/1940-6207.c.6544745

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Supplementary Figure Legend from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802bed54f582a8c8206168f8e3e8abdc
https://doi.org/10.1158/1940-6207.22525430.v1

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Supplementary Figure 1 from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

PDF file - 9245K, Supplementary Figure S1. Baseline endometrial abnormalities detected in the pre-treatment biopsies from these high-risk women.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6b7882b853eb18ad7f5da7177f71d6
https://doi.org/10.1158/1940-6207.22525433

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Commentary on This Article from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4bd5f9e918583b91f9bd2611e21cd1
https://doi.org/10.1158/1940-6207.22525436.v1

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Supplementary Table 1 from Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

XLSX file - 34K, Supplementary Table S1. Probes and primers for real-time PCR biomarker assays.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341d41dd3114236e9a38afa198779a29
https://doi.org/10.1158/1940-6207.22525427

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Akademický článek

Autor: Juan Guevara, Jr., Nagindra Prashad, Boris Ermolinsky, John W. Gaubatz, Dongcheul Kang, Andrea E. Schwarzbach, David S. Loose, Natalia Valentinova Guevara

Publikováno v: Journal of Lipid Research, Vol 51, Iss 7, Pp 1704-1718 (2010)

LDL mediates transfection with plasmid DNA in a variety of cell types in vitro and in several tissues in vivo in the rat. The transfection capacity of LDL is based on apo B100, as arginine/lysine clusters, suggestive of nucleic acid-binding domains a

Externí odkaz: https://doaj.org/article/7c5de210851e446e95913291efdc7d4a

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Differential proteome profile, biological pathways, and network relationships of osteogenic proteins in calcified human aortic valves

Autor: Li Li, K. Jane Grande-Allen, Jennifer P. Connell, David S. Loose, Richard I Han, Li Yang, Gerald M. Lawrie, Amina A. Qutub, Joel D. Morrisett, Chenyue W. Hu, Michael J. Reardon

Publikováno v: Heart and vessels. 37(2)

Calcific aortic valve disease (CAVD) is the most common heart valve disease requiring intervention. Most research on CAVD has focused on inflammation, ossification, and cellular phenotype transformation. To gain a broader picture into the wide range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7f1ab316d64ce5eb7f4dfa5e2d7d83
https://pubmed.ncbi.nlm.nih.gov/34727208

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Akademický článek

Laser capture microdissected mucosa versus whole tissue specimens for assessment of radiation-induced dynamic molecular and pathway changes in the small intestine.

Autor: Junying Zheng, Sarita Garg, Junru Wang, David S Loose, Martin Hauer-Jensen

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53711 (2013)

The intestinal mucosa is the compartment that sustains the most severe injury in response to radiation and is therefore of primary interest. The use of whole gut extracts for analysis of gene expression may confound important changes in the mucosa. O

Externí odkaz: https://doaj.org/article/e95a78e092974e4f90d88098282311e4

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