Zobrazeno 1 - 10
of 55
pro vyhledávání: '"S Limpert"'
Publikováno v:
New Journal of Physics, Vol 17, Iss 9, p 095004 (2015)
Hot-carrier solar cells are envisioned to utilize energy filtering to extract power from photogenerated electron–hole pairs before they thermalize with the lattice, and thus potentially offer higher power conversion efficiency compared to conventio
Externí odkaz:
https://doaj.org/article/d12b213286254b67a079f868f84f638b
Autor:
Carolina L. Haass-Koffler, T. Chase Francis, Pauravi Gandhi, Reesha Patel, Mohammad Naemuddin, Carsten K. Nielsen, Selena E. Bartlett, Antonello Bonci, Stefan Vasile, Becky L. Hood, Eigo Suyama, Michael P. Hedrick, Layton H. Smith, Allison S. Limpert, Marisa Roberto, Nicholas D.P. Cosford, Douglas J. Sheffler
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 448-459 (2022)
Background: Stress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRF1 and CRF2), and the CRF-binding protein (CRFBP). Whereas decades of research has focused on CRF1, the role of CRF2 in the centra
Externí odkaz:
https://doaj.org/article/252e585012f34a709aeedb261348a1af
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 717-732 (2013)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with few therapeutic options. While several gene mutations have been implicated in ALS, the exact cause of neuronal dysfunction is unknown and motor neurons of affected individ
Externí odkaz:
https://doaj.org/article/d18a76b00dbf429ba172335302c370af
Autor:
Allison S. Limpert, Lena M. Berger, Stefan Knapp, Lester J. Lambert, Nicholas D. P. Cosford, Fabiana I.A.L. Layng, Apirat Chaikuad, Cunxiang Yuan, Jing Dong, Li Wang, Maria Celeridad, Yi Peng, Douglas J. Sheffler, Nicole Bata, Guoxiong Liu, Nicole A Bakas
Publikováno v:
J Med Chem
Serine/threonine-protein kinases 3 and 4 (STK3 and STK4, respectively) are key components of the Hippo signaling pathway, which regulates cell proliferation and death and provides a potential therapeutic target for acute myeloid leukemia (AML). Herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc05bd607eb905af295851148fa0764
https://europepmc.org/articles/PMC10149138/
https://europepmc.org/articles/PMC10149138/
Autor:
Sonja N. Brun, Gencer Sancar, Jan Lumibao, Allison S. Limpert, Huiyu Ren, Angela Ianniciello, Herve Tiriac, Michael Downes, Danielle D. Engle, Ronald M. Evans, Nicholas D.P. Cosford, Reuben J. Shaw
Amongst cancer subtypes, pancreatic ductal adenocarcinoma (PDA) has been demonstrated to be most sensitive to autophagy inhibition, which may be due to unique metabolic rewiring in these cells. The serine/threonine kinase ULK1 forms the catalytic cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9cd979bb7e86417dcc2356901a2c92
https://doi.org/10.1101/2021.05.15.444304
https://doi.org/10.1101/2021.05.15.444304
Autor:
Peibin Yue, Yinsong Zhu, Christine Brotherton-Pleiss, Wenzhen Fu, Nagendra Verma, Jasmine Chen, Kayo Nakamura, Weiliang Chen, Yue Chen, Felix Alonso-Valenteen, Simoun Mikhael, Lali Medina-Kauwe, Kathleen M. Kershaw, Maria Celeridad, Songqin Pan, Allison S. Limpert, Douglas J. Sheffler, Nicholas D.P. Cosford, Stephen L. Shiao, Marcus A. Tius, Francisco Lopez-Tapia, James Turkson
Publikováno v:
Cancer Letters. 534:215613
Signal transducer and activator of transcription (Stat)3 is a valid anticancer therapeutic target. We have discovered a highly potent chemotype that amplifies the Stat3-inhibitory activity of lead compounds to levels previously unseen. The azetidine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bfce83f0ed10d7ee0394d021f258e2
https://doi.org/10.1016/j.canlet.2022.215613
https://doi.org/10.1016/j.canlet.2022.215613
Autor:
Nicole A Bakas, Lester J. Lambert, Nicholas D. P. Cosford, Mitchell Vamos, Huiyu Ren, Apirat Chaikuad, Reuben J. Shaw, Carina Wimer, Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Sonja N. Brun, Allison S. Limpert, Stefan Knapp
Publikováno v:
J Med Chem
Inhibition of autophagy, the major cellular recycling pathway in mammalian cells, is a promising strategy for the treatment of triple-negative breast cancer (TNBC). We previously reported SBI-0206965, a small molecule inhibitor of unc-51-like autopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e4b2f1d43e7a3f43e170153e08bf32
https://europepmc.org/articles/PMC8064294/
https://europepmc.org/articles/PMC8064294/
Autor:
Darren Finlay, Nicole Bata, Dominik Heimann, Nicholas D. P. Cosford, Allison S. Limpert, Carol Burian, Kristiina Vuori, Peter Teriete, James R. Mason
Publikováno v:
Cancer Research. 80:2405-2405
Acute myeloid leukemia (AML) is a diverse collection of hematological cancers characterized by the bone marrow's excessive production of certain immature myeloid blood cells. The American Cancer Society estimated that there was ~11,000 deaths and ~21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607b25fdef6ed57645f2dbe0a36e44eb
https://doi.org/10.1158/1538-7445.am2020-2405
https://doi.org/10.1158/1538-7445.am2020-2405
Autor:
Allison S. Limpert, Malene Hansen, Nicole Bata, Apirat Chaikuad, Lester J. Lambert, Nicholas D. P. Cosford, Stefan Knapp
Publikováno v:
Molecular Cancer Research. 18:B05-B05
The serine/threonine-protein kinases 3 (STK3, MST2) and 4 (STK4, MST1) are the “core kinase cassette” of the Hippo signaling pathway, directing cell proliferation and differentiation through control of the downstream transcription factors, YAP an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3f63a44728be0caeffbe05076e7fc7
https://doi.org/10.1158/1557-3125.hippo19-b05
https://doi.org/10.1158/1557-3125.hippo19-b05
Autor:
Daniel Grant, Peter Teriete, John C. Reed, Pooi-San Lee, Anna Dembo, Douglas J. Sheffler, Nicholas D. P. Cosford, Haixia Zou, Gavin Magnuson, Allison S. Limpert, Jiwen Zou, Anthony B. Pinkerton, Mark E. Goldman, Robert Ardecky, Juan Rong
Publikováno v:
ACS Chemical Neuroscience
Endoplasmic reticulum (ER) stress causes neuronal dysfunction followed by cell death and is recognized as a feature of many neurodegenerative diseases. Using a phenotypic screen, we recently identified benzodiazepinone derivatives that reduce ER stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3765e5e274ee9a6fd3a4d5f98c7f45db
https://doi.org/10.1021/cn500297v
https://doi.org/10.1021/cn500297v