Zobrazeno 1 - 10
of 760
pro vyhledávání: '"S Lilley"'
Autor:
Lisa M. Breckels, Thomas Krueger, Charlotte Hutchings, Charlotte S. Dawson, Kathryn S. Lilley
Publikováno v:
F1000Research, Vol 12 (2024)
Background Expression proteomics involves the global evaluation of protein abundances within a system. In turn, differential expression analysis can be used to investigate changes in protein abundance upon perturbation to such a system. Methods Here,
Externí odkaz:
https://doaj.org/article/af494e36b21e41fe9d82f83176e4cef2
Autor:
Mie Monti, Reyme Herman, Leonardo Mancini, Charlotte Capitanchik, Karen Davey, Charlotte S Dawson, Jernej Ule, Gavin H Thomas, Anne E Willis, Kathryn S Lilley, Eneko Villanueva
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 573-589 (2024)
Abstract Characterising RNA–protein interaction dynamics is fundamental to understand how bacteria respond to their environment. In this study, we have analysed the dynamics of 91% of the Escherichia coli expressed proteome and the RNA-interaction
Externí odkaz:
https://doaj.org/article/76a13b8e569f4c31bb10fc845610029f
Autor:
Nicola M. Moloney, Konstantin Barylyuk, Eelco Tromer, Oliver M. Crook, Lisa M. Breckels, Kathryn S. Lilley, Ross F. Waller, Paula MacGregor
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract African trypanosomes are dixenous eukaryotic parasites that impose a significant human and veterinary disease burden on sub-Saharan Africa. Diversity between species and life-cycle stages is concomitant with distinct host and tissue tropisms
Externí odkaz:
https://doaj.org/article/4b9d48efa44641b7907a810038aabed8
Autor:
Marta Baldrighi, Christian Doreth, Yang Li, Xiaohui Zhao, Emily Warner, Hannah Chenoweth, Kamal Kishore, Yagnesh Umrania, David-Paul Minde, Sarah Thome, Xian Yu, Yuning Lu, Alice Knapton, James Harrison, Murray Clarke, Eicke Latz, Guillermo de Cárcer, Marcos Malumbres, Bernhard Ryffel, Clare Bryant, Jinping Liu, Kathryn S. Lilley, Ziad Mallat, Xuan Li
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Unabated activation of the NLR family pyrin domain–containing 3 (NLRP3) inflammasome is linked with the pathogenesis of various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both phar
Externí odkaz:
https://doaj.org/article/9ec59b6ac22e465f89c2f85931f35cac
Autor:
Lisa M. Breckels, Thomas Krueger, Charlotte Hutchings, Charlotte S. Dawson, Kathryn S. Lilley
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Expression proteomics involves the global evaluation of protein abundances within a system. In turn, differential expression analysis can be used to investigate changes in protein abundance upon perturbation to such a system. Methods: Her
Externí odkaz:
https://doaj.org/article/8888ada0ba0141bd95a4e812ae1a0a0c
Autor:
Oliver M. Crook, Colin T. R. Davies, Lisa M. Breckels, Josie A. Christopher, Laurent Gatto, Paul D. W. Kirk, Kathryn S. Lilley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Changes in protein subcellular localization can be determined using mass spectrometry. Here, the authors present a statistical approach to determine relocalising proteins from spatial proteomics experiments.
Externí odkaz:
https://doaj.org/article/2ab3daf7eb8d40e0ab4ad9e1fbd4cdd3
Autor:
Vadim Demichev, Lukasz Szyrwiel, Fengchao Yu, Guo Ci Teo, George Rosenberger, Agathe Niewienda, Daniela Ludwig, Jens Decker, Stephanie Kaspar-Schoenefeld, Kathryn S. Lilley, Michael Mülleder, Alexey I. Nesvizhskii, Markus Ralser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity of mass spectrometry-based proteomics. The authors present algorithms and a software solution, which boost proteomic depth in dia-PASEF expe
Externí odkaz:
https://doaj.org/article/530223c882bd4d63b31f0e4036920910
Autor:
Tobias von der Haar, Thomas E. Mulroney, Fabio Hedayioglu, Sathishkumar Kurusamy, Maria Rust, Kathryn S. Lilley, James E. Thaventhiran, Anne E. Willis, C. Mark Smales
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In vitro transcribed, modified messenger RNAs (IVTmRNAs) have been used to vaccinate billions of individuals against the SARS-CoV-2 virus, and are currently being developed for many additional therapeutic applications. IVTmRNAs must be translated int
Externí odkaz:
https://doaj.org/article/a6fe20fc312948cb980fb2feac3e94c1
Autor:
Claire M. Mulvey, Lisa M. Breckels, Oliver M. Crook, David J. Sanders, Andre L. R. Ribeiro, Aikaterini Geladaki, Andy Christoforou, Nina Kočevar Britovšek, Tracey Hurrell, Michael J. Deery, Laurent Gatto, Andrew M. Smith, Kathryn S. Lilley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
“Protein relocalisation plays a major role in the innate immune response but remains incompletely characterised. Here, the authors combine temporal proteomics with LOPIT, a spatial proteomic workflow, in a fully Bayesian framework to elucidate spat
Externí odkaz:
https://doaj.org/article/b7981d765ae3484fb2248a1903f40b99
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Fang et al. develop a Bayesian data analysis approach that is better suited to the analysis of Thermal Proteome Profiling (TPP) data than existing data analysis approaches that have limitations with respect to deviations from the expected sigmoid dat
Externí odkaz:
https://doaj.org/article/7779bba951a04cb6ad7afed9774db400