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P577 A Phase 1b Study to Evaluate Safety, Tolerability, Pharmacokinetics and Clinical Efficacy of the Nucleotide-binding oligomerization domain, Leucine rich Repeat containing X1 (NLRX1) agonist NX-13 in Ulcerative Colitis

Autor: L Peyrin-Biroulet, S Danese, J F Colombel, F Rieder, A Yarur, B Verstockt, S Lichtiger, R Mosig, F Cataldi, B Feagan

Publikováno v: Journal of Crohn's and Colitis. 17:i705-i706

Background NLRX1 is a mitochondrial membrane protein whose activation reduces oxidative stress and decreases effector cell differentiation and cytokine release. NX-13 is a first-in-class, orally active, gut selective NLRX1 agonist with low systemic e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4f1fd9c41682c5a55909670d45409ec
https://doi.org/10.1093/ecco-jcc/jjac190.0707

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The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior infliximab therapy

Autor: S, Lichtiger, D G, Binion, D C, Wolf, D H, Present, A G, Bensimon, E, Wu, A P, Yu, A T, Cardoso, J, Chao, P M, Mulani, K G, Lomax, J D, Kent

Publikováno v: Alimentary pharmacologytherapeutics. 32(10)

Adalimumab induces and maintains remission in adults with Crohn's disease.To evaluate safety, fistula healing, quality of life and work productivity in adalimumab-treated patients who failed infliximab, including primary nonresponders.After a ≥8-we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7db4605410b27fc7511624a9562fddcd
https://pubmed.ncbi.nlm.nih.gov/20955442

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Ulcerative colitis and sarcoidosis

Autor: N, Nilubol, P J, Taub, M, Venturero, S, Lichtiger, J J, Bauer

Publikováno v: The Mount Sinai journal of medicine, New York. 68(6)

A 38-year-old woman with ulcerative colitis subsequently developed sarcoidosis. After ten years of recurrent episodes of colitis, she had presented with respiratory symptoms. The diagnosis of sarcoidosis was confirmed by mediastinal lymph node biopsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9374981253de0f9ac1be23144b547829
https://pubmed.ncbi.nlm.nih.gov/11687869

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Gold-induced colitis: a case report and review of the literature

Autor: V, Teodorescu, J, Bauer, S, Lichtiger, M, Chapman

Publikováno v: The Mount Sinai journal of medicine, New York. 60(3)

A case of severe colitis requiring subtotal colectomy following administration of 35 mg Solganal b for intractable arthritis is described. Abdominal pain and watery diarrhea developed six weeks after the last dose of gold. Colonoscopy revealed mucosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19d49c5d95797f361821b2fa6fece185
https://pubmed.ncbi.nlm.nih.gov/8345852

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SONIC: A randomized, double-blind, controlled trial comparing Infliximab and Infliximab plus Azathioprine to Azathioprine in patients with Crohnʼs Disease naive to immunomodulators and biologic therapy

Autor: W Sandborn, P Rutgeerts, W Reinisch, G Mantzaris, A Kornbluth, D Rachmilewitz, S Lichtiger, G DʼHaens, C van der Woude, R Diamond, D Broussard, R Hegedus, J Colombel

Publikováno v: Inflammatory Bowel Diseases. 14:S1

INTRODUCTION: The pathogenesis of inflammatory bowel disease (IBD) is believed to be mediated primarily by T cells through an aberrant immunologic response to commensal bacteria. The innate immune response also plays an important role as evidenced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80b9aa554a8f1ca14faaf30eaf1c2cd9
https://doi.org/10.1002/ibd.20829

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