Zobrazeno 1 - 10
of 1 153
pro vyhledávání: '"S Leslie"'
Autor:
Samuel Joseph Kaplan, Wilfred Wong, Jielin Yan, Julian Pulecio, Hyein S. Cho, Qianzi Li, Jiahui Zhao, Jayanti Leslie-Iyer, Jonathan Kazakov, Dylan Murphy, Renhe Luo, Kushal K. Dey, Effie Apostolou, Christina S. Leslie, Danwei Huangfu
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114640- (2024)
Summary: Functional enhancer annotation is critical for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants. However, unbiased enhancer discovery in disease-relevant contexts remains challe
Externí odkaz:
https://doaj.org/article/18884ea54402465ca393dbb1bcd2118f
Publikováno v:
Signals, Vol 5, Iss 1, Pp 40-59 (2024)
We consider the challenge of detecting and clustering point and collective anomalies in streaming data that exhibit significant nonlinearities and seasonal structures. The challenge is motivated by detecting problems in a communications network, wher
Externí odkaz:
https://doaj.org/article/e62ffa92987d42f9bf739ffefb9dde72
Autor:
Rui Yang, Arnav Das, Vianne R. Gao, Alireza Karbalayghareh, William S. Noble, Jeffrey A. Bilmes, Christina S. Leslie
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/9e27b8675a2a42da9d2482ac953dcd45
Autor:
Rui Yang, Arnav Das, Vianne R. Gao, Alireza Karbalayghareh, William S. Noble, Jeffrey A. Bilmes, Christina S. Leslie
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Recent deep learning models that predict the Hi-C contact map from DNA sequence achieve promising accuracy but cannot generalize to new cell types and or even capture differences among training cell types. We propose Epiphany, a neural netwo
Externí odkaz:
https://doaj.org/article/03e9075f1972485484f1aafb6af44eb5
Publikováno v:
JAAD Case Reports, Vol 35, Iss , Pp 98-102 (2023)
Externí odkaz:
https://doaj.org/article/afea68895fab4aa8ad6bff70cf34b6bd
Publikováno v:
JAAD Case Reports, Vol 32, Iss , Pp 84-87 (2023)
Externí odkaz:
https://doaj.org/article/b6a4dc3314354939961f48385397e8a0
Autor:
Tatiana Erazo, Chiara M. Evans, Daniel Zakheim, Eren L. Chu, Alice Yunsi Refermat, Zahra Asgari, Xuejing Yang, Mariana Da Silva Ferreira, Sanjoy Mehta, Marco Vincenzo Russo, Andrea Knezevic, Xi-Ping Zhang, Zhengming Chen, Myles Fennell, Ralph Garippa, Venkatraman Seshan, Elisa de Stanchina, Olena Barbash, Connie Lee Batlevi, Christina S. Leslie, Ari M. Melnick, Anas Younes, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer
Externí odkaz:
https://doaj.org/article/ae7897107ec04e2091ae2adabb8a333a
Autor:
Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, Song Han, Amrita M. Nargund, Shaoyuan Yang, Yang Lyu, James J. Hsieh, Christina S. Leslie, Emily H. Cheng
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
SETD2, a H3K36 trimethyltransferase, is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. However, how SETD2 loss of function promotes tumorigenesis remains unclear. Using condition
Externí odkaz:
https://doaj.org/article/609d7648d45a4ebb9f934f1c8a5d9339
Autor:
Naveed Sattar, Paul Welsh, Wilma S. Leslie, George Thom, Louise McCombie, Naomi Brosnahan, Janice Richardson, Jason M.R. Gill, Luisa Crawford, Michael E.J. Lean
Publikováno v:
The Lancet Regional Health - Southeast Asia, Vol 9, Iss , Pp 100111- (2023)
Summary: Background: We aimed to assess whether a structured weight management programme incorporating a total diet replacement (TDR) (3–5 months ∼850 kcal/day formula diet) weight loss phase is acceptable to people of South Asian ethnicity and c
Externí odkaz:
https://doaj.org/article/cfb1714bc3b34eb0809464e76db099e2
Publikováno v:
JAAD Case Reports, Vol 28, Iss , Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/4eaaa434456a4156b7ac20d5e2613808