Zobrazeno 1 - 10
of 109
pro vyhledávání: '"S Lee Adamson"'
Autor:
Lois Kelsey, Ann M Flenniken, Dawei Qu, Alister P W Funnell, Richard Pearson, Yu-Qing Zhou, Irina Voronina, Zorana Berberovic, Geoffrey Wood, Susan Newbigging, Edward S Weiss, Michael Wong, Ivan Quach, S Y Sandy Yeh, Ashish R Deshwar, Ian C Scott, Colin McKerlie, Mark Henkelman, Peter Backx, Jeremy Simpson, Lucy Osborne, Janet Rossant, Merlin Crossley, Benoit Bruneau, S Lee Adamson
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003612 (2013)
KLF3 is a Krüppel family zinc finger transcription factor with widespread tissue expression and no previously known role in heart development. In a screen for dominant mutations affecting cardiovascular function in N-ethyl-N-nitrosourea (ENU) mutage
Externí odkaz:
https://doaj.org/article/ab76a1b77a544037ba7f516ea6b26768
Autor:
Nicole M Anderson, Mojib Javadi, Elizabeth Berndl, Zorana Berberovic, Monica L Bailey, Kai Huang, Ann M Flenniken, Lucy R Osborne, S Lee Adamson, Janet Rossant, Christin Carter-Su, Chen Wang, Kelly M McNagny, Robert F Paulson, Mark D Minden, William L Stanford, Dwayne L Barber
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75472 (2013)
Utilizing ENU mutagenesis, we identified a mutant mouse with elevated platelets. Genetic mapping localized the mutation to an interval on chromosome 19 that encodes the Jak2 tyrosine kinase. We identified a A3056T mutation resulting in a premature st
Externí odkaz:
https://doaj.org/article/0199f61192784ce99fbae49a0da0fce4
Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
Autor:
Lisa Yu, Issaka Yougbaré, Jelena Brkić, Brigitta Elaine Oswald, Heyu Ni, Darko Zdravic, John Freedman, Howard Leong-Poi, Guangheng Zhu, S. Lee Adamson, Caroline Dunk, Jianhong Zhang, Dawei Qu, Duncan J. Stewart, Sean Lang, Chun Peng, Xiao-Yan Wen, Stephen J. Lye, John G. Sled, Petter Höglund, Wei-She Tai, B. Anne Croy
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it is unknown whether placental, decidual im
Publikováno v:
Placenta. 46:11-17
Introduction Placental examination is recommended when genetic mutations cause fetal lethality in mice. But how fetal death alters histomorphology of the surviving mouse placenta is not known. Methods Placentas were examined at E17.5 after fetectomy
Introduction The fetoplacental vasculature network is essential for the exchange of nutrients, gases and wastes with the maternal circulation and for normal fetal development. The present study quantitatively compares arterial and venous morphologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c520e7571d6658e1c01e2def3be7d8
https://europepmc.org/articles/PMC5679460/
https://europepmc.org/articles/PMC5679460/
Autor:
Mike Seed, Anum Rahman, John G. Sled, Yu-Qing Zhou, Lindsay S. Cahill, Christopher K. Macgowan, Monique Y. Rennie, John Kingdom, S. Lee Adamson, Johnathan Hoggarth
Publikováno v:
American journal of obstetrics and gynecology. 217(4)
Background Many stillbirths of normally formed fetuses in the third trimester could be prevented via delivery if reliable means to anticipate this outcome existed. However, because the etiology of these stillbirths is often unexplained and although t
Autor:
John G. Sled, S. Lee Adamson, Graeme N. Smith, Carolina C. Venditti, Malia S. Q. Murphy, Richard Casselman
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 305:R939-R948
End-tidal breath carbon monoxide (CO) is abnormally low in women with preeclampsia (PE), while women smoking during pregnancy have shown an increase in CO levels and a 33% lower incidence of PE. This effect may be, in part, due to lowered sFLT1 plasm
Publikováno v:
Hypertension. 61:259-266
It is not known whether eNOS deficiency in the mother or the conceptus (ie, placenta and fetus) causes fetal growth restriction in mice lacking the endothelial NO synthase gene (eNOS knockout [KO]). We hypothesized that eNOS sustains fetal growth by
Autor:
S. Lee Adamson
Publikováno v:
Placenta. 43
I readwith great interest the recent paper by Bednov et al. [1], in which they showed that L-arginine added to the fetal perfusate blunts hypoxia-induced fetal vasoconstriction in the perfused human placental cotyledon. Using a similar placental perf
Autor:
Dawei Qu, Abhijeet Minhas, Kathie J. Whiteley, John G. Sled, Shannon Bainbridge, John Kingdom, S. Lee Adamson
Publikováno v:
Hypertension. 59:732-739
Preeclampsia is a life-threatening disorder characterized by maternal gestational hypertension and proteinuria that results from placental dysfunction. Placental abnormalities include abnormal syncytiotrophoblast and a 50% reduction in placental expr