Zobrazeno 1 - 10
of 652
pro vyhledávání: '"S Lay"'
Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapi
Externí odkaz:
https://doaj.org/article/86032f589b894097a542dab777945e85
Autor:
Ryo Sakagami, Florian S. Lay, Andreas Dömel, Martin J. Schuster, Alin Albu-Schäffer, Freek Stulp
Publikováno v:
Frontiers in Robotics and AI, Vol 10 (2023)
The term “world model” (WM) has surfaced several times in robotics, for instance, in the context of mobile manipulation, navigation and mapping, and deep reinforcement learning. Despite its frequent use, the term does not appear to have a concise
Externí odkaz:
https://doaj.org/article/ed73c98cf73c48069f90adfbae2b6849
Interdependent iron and phosphorus availability controls photosynthesis through retrograde signaling
Autor:
Hye-In Nam, Zaigham Shahzad, Yanniv Dorone, Sophie Clowez, Kangmei Zhao, Nadia Bouain, Katerina S. Lay-Pruitt, Huikyong Cho, Seung Y. Rhee, Hatem Rouached
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Iron deficiency induces chlorosis in plants but only when phosphate supply is sufficient. Here, the authors show that phosphate-dependency is governed by a ROS-mediated retrograde signaling pathway involving the PHT4;4 chloroplast ascorbate transport
Externí odkaz:
https://doaj.org/article/228cdcb02f964a20a5b0e92f97e42b11
Publikováno v:
HardwareX, Vol 12, Iss , Pp e00329- (2022)
CubeSats were conceived with an aim to provide students with hands-on, design, build, and test experiences on spacecraft. Many education-class CubeSats keep the cost of the projects low with the use of commercial off-the-shelf (COTS) products. But us
Externí odkaz:
https://doaj.org/article/c6e4253b6eb54c0fa3ccf4ce145737b3
Autor:
Charles S. Lay, Daniel A. Thomas, John P. Evans, Emma J. Jones, Kelly M. Gatfield, Peter D. Craggs
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101078- (2022)
Summary: The Kinetic Intra-Cellular Assay (KICA) is a recombinant cell-based technique that utilizes NanoBRET technology. KICA enables the measurement of intracellular binding kinetics. This protocol describes steps for cellular transfection and expr
Externí odkaz:
https://doaj.org/article/bef9a962d1c24509b55841d676162543
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Excess weight and unexpected weight loss are associated with multiple disease states and increased morbidity and mortality, but weight measurement is not routine in many primary care settings. The aim of this study was to characte
Externí odkaz:
https://doaj.org/article/5c851f2e13ad41059ef47841ec8c66ee
Publikováno v:
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol IV-2-W5, Pp 503-511 (2019)
Landslide is painstaking as one of the most prevalent and devastating forms of mass movement that affects man and his environment. The specific objective of this research paper is to investigate the application and performances of some selected machi
Externí odkaz:
https://doaj.org/article/b449f3d7a9cc4f7e993789b2d84758b1
Publikováno v:
British Journal of Pharmacology. 180:1444-1459
Interleukin-23 (IL-23) and its receptor are important drug targets for the treatment of auto-inflammatory diseases. IL-23 binds to a receptor complex composed of two single transmembrane spanning proteins IL23R and IL12Rβ1. In this study we aimed to
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Akademický článek
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