Výsledky vyhledávání

Antibody to beta3 integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat

Autor: S L Settle, M H Helfrich, B A Crippes, J Delarco, V W Engleman, R L Ornberg, G A Nickols, M A Horton

Publikováno v: Endocrinology. 137:918-924

The cell surface integrin, alphaVbeta3, is important for the attachment of osteoclasts to bone matrix and the subsequent resorption of bone. The present study was designed to determine the effects of F11, a monoclonal antibody to the rat beta3 subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a91829855e59504af8ba9261c20087
https://doi.org/10.1210/endo.137.3.8603604

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Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase

Autor: Nickols Ga, M Krukowski, Thomas P. Misko, S. L. Settle, N Patel, Patricia Collin-Osdoby, Mark G. Currie, Thomas P. Kasten, Philip Osdoby

Publikováno v: Proceedings of the National Academy of Sciences. 91:3569-3573

We have examined the effects of modulating nitric oxide (NO) levels on osteoclast-mediated bone resorption in vitro and the effects of nitric oxide synthase (NOS) inhibitors on bone mineral density in vivo. Diaphorase-based histochemical staining for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e925b739187a89d63f2ce1c26cebc61
https://doi.org/10.1073/pnas.91.9.3569

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Modification of inflammatory response to implanted biomedical materials in vivo by surface bound superoxide dismutase mimics

Autor: K, Udipi, R L, Ornberg, K B, Thurmond, S L, Settle, D, Forster, D, Riley

Publikováno v: Journal of biomedical materials research. 51(4)

The healing response to implanted biomedical materials involves varying degrees and stages of inflammation and healing which in some cases leads to device failure. In this article, we describe synthetic methods and in vivo results of a novel surface

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18f1a3e84eedf097c991b53f813a2d53
https://pubmed.ncbi.nlm.nih.gov/10880102

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Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry

Autor: C M, Schmidt, S L, Settle, J L, Keene, W F, Westlin, G A, Nickols, D W, Griggs

Publikováno v: Clinicalexperimental metastasis. 17(6)

Studies of metastasis can be accelerated and provide more mechanistic information using cell lines which reproducibly and aggressively metastasize, and which are accurately and easily detected in tissues at all stages of the metastatic process. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::849a3739ab623a3a9a06d21ee873dbf7
https://pubmed.ncbi.nlm.nih.gov/10763921

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Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors

Autor: J L, Masferrer, K M, Leahy, A T, Koki, B S, Zweifel, S L, Settle, B M, Woerner, D A, Edwards, A G, Flickinger, R J, Moore, K, Seibert

Publikováno v: Cancer research. 60(5)

We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor growth by inducing newly formed blood vessels (neoangiogenesis) that sustain tumor cell viability and growth. COX-2 is expressed within human tumor neovasculat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfc1deb70463865f2409c1d4a05a659c
https://pubmed.ncbi.nlm.nih.gov/10728691

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A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy

Autor: C P, Carron, D M, Meyer, J A, Pegg, V W, Engleman, M A, Nickols, S L, Settle, W F, Westlin, P G, Ruminski, G A, Nickols

Publikováno v: Cancer research. 58(9)

The integrin alpha(v)beta3 interacts with the arginine-glycine-aspartic acid (RGD) tripeptide recognition sequence of a variety of extracellular matrix proteins. Recent studies show that alpha(v)beta3 plays an important role in tumor-induced angiogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::723536788f9adc75b5007c6fd027b69a
https://pubmed.ncbi.nlm.nih.gov/9581835

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Nitric oxide and the cyclooxygenase pathway

Autor: D, Salvemini, K, Seibert, J L, Masferrer, S L, Settle, T P, Misko, M G, Currie, P, Needleman

Publikováno v: Advances in prostaglandin, thromboxane, and leukotriene research. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc615272ebe7fba9aaee6d215dcdb5e5
https://pubmed.ncbi.nlm.nih.gov/7537440

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Hypotension induced by intravascular administration of nerve growth factor in the rat

Autor: Martin R. Wilkins, S L Settle, Q Yan

Publikováno v: Clinical science (London, England : 1979). 80(6)

1. The observation that the area postrema expresses a high level of nerve-growth-factor-receptor immunoreactivity prompted an investigation of the effects of nerve growth factor on autonomic function in the rat. 2. Bolus injection of pharmacological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fba9edf0c116c88a8de68f553403b35
https://pubmed.ncbi.nlm.nih.gov/1647918

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Infective endocarditis and the dental practitioner

Autor: J M, Beckerley, S L, Settle

Publikováno v: Journal - Oklahoma Dental Association. 80(3)

The purpose of this article is to assist the dental practitioner in making informed decisions concerning the treatment of patients "at risk" for developing infective endocarditis following dental procedures.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::499a7eccff531d11005ef854ad927d26
https://pubmed.ncbi.nlm.nih.gov/2142503

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