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A major role for matrix metalloproteinases in T cell injury in the gut

Autor: S L Pender, S P Tickle, A J Docherty, D Howie, N C Wathen, T T MacDonald

Publikováno v: The Journal of Immunology. 158:1582-1590

Activated lamina propria T cells responding to luminal Ags are thought to be important in celiac disease and Crohn's disease, and T cells responding to foreign MHC products are also important in intestinal graft-vs-host disease and intestinal transpl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3371101dd9ff03bdd0669063a5d7a3c
https://doi.org/10.4049/jimmunol.158.4.1582

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Interferon-alpha drives T cell-mediated immunopathology in the intestine

Autor: G, Monteleone, S L, Pender, N C, Wathen, T T, MacDonald

Publikováno v: European journal of immunology. 31(8)

The ability of interferon (IFN)-alpha to induce autoimmunity and exacerbate Th1 diseases is well known. We have recently described enhanced expression of IFN-alpha in the mucosa of patients with celiac disease (CD), a gluten-sensitive Th1-mediated en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::153d66a731c1cc754f79deef2c6d17dc
https://pubmed.ncbi.nlm.nih.gov/11477536

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Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease

Autor: G, Monteleone, S L, Pender, E, Alstead, A C, Hauer, P, Lionetti, C, McKenzie, T T, MacDonald

Publikováno v: Gut. 48(3)

Coeliac disease (CD) is caused by a CD4 T helper cell type 1 (Th1) response in the small intestinal mucosa to dietary gluten. As the major Th1 inducing cytokine, interleukin 12, is undetectable in CD gut mucosa, the mechanism by which Th1 effector ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3f0ddcb52c2e179f30f1ad4a960678
https://pubmed.ncbi.nlm.nih.gov/11171837

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Lamina propria T cells

Autor: T T, MacDonald, S L, Pender

Publikováno v: Chemical immunology. 71

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ecfe8edd4032d5477749c180adf90064
https://pubmed.ncbi.nlm.nih.gov/9761950

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A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production

Autor: S L, Pender, J M, Fell, S M, Chamow, A, Ashkenazi, T T, MacDonald

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(8)

Anti-TNF-alpha Ab therapy has been shown to be of benefit in the treatment of active Crohn's disease, but the tissue-injuring processes in the gut mediated by TNF-alpha that might be inhibited by neutralizing Ab are unknown. In this work, we have use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3d1024d0f81c3643b11e06d0ab23291
https://pubmed.ncbi.nlm.nih.gov/9558121

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A major role for matrix metalloproteinases in T cell injury in the gut

Autor: S L, Pender, S P, Tickle, A J, Docherty, D, Howie, N C, Wathen, T T, MacDonald

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::430055b1e5b23d147d762c983e448b21
https://pubmed.ncbi.nlm.nih.gov/9029093

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