Výsledky vyhledávání - "S L Morrison"

Functional and pharmacokinetic properties of antibody-avidin fusion proteins

Autor: S U Shin, D Wu, R Ramanathan, W M Pardridge, S L Morrison

Publikováno v: The Journal of Immunology. 158:4797-4804

In an attempt to produce broadly useful targeting agents, genetic engineering and expression techniques have been used to produce Ab-avidin fusion proteins. Chicken avidin has been fused to mouse-human chimeric IgG3 at the end of C(H)1 (C(H)1-Av), im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::530fee6b9ee01a4f4dc02d344fbfce9b
https://doi.org/10.4049/jimmunol.158.10.4797

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The hinge as a spacer contributes to covalent assembly and is required for function of IgG

Autor: M J Coloma, K R Trinh, L A Wims, S L Morrison

Publikováno v: The Journal of Immunology. 158:733-740

Chimeric IgG3 lacking a genetic hinge but with Cys residues in CH2 between position 231 and 232 (IgG3 deltaH+Cys) and position 279 (IgG3 deltaH+2Cys) produced by site-directed mutagenesis have been found to be deficient in their intermolecular assemb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db05e28c2922ab0b54b653e590c695f7
https://doi.org/10.4049/jimmunol.158.2.733

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Elimination of N-linked glycosylation sites from the human IgA1 constant region: effects on structure and function

Autor: P D Chuang, S L Morrison

Publikováno v: The Journal of Immunology. 158:724-732

IgA1 Abs possess conserved N-linked glycosylation sites in the second C region and secreted tailpiece domains. To understand the role of these carbohydrates in the structure and function of human IgA1, site-directed mutants that produce human IgA1 la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da8c2abef9bfd4c59c9cfd48803eb9c4
https://doi.org/10.4049/jimmunol.158.2.724

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Bifunctional fusion between nerve growth factor and a transferrin receptor antibody

Autor: S. D. Putney, X Cao, P Lynch, J. P. McGrath, Ted Ebendal, S L Morrison, A. J. Schutz, M J Coloma

Publikováno v: Journal of Neuroscience Research. 47:123-133

The cDNAs encoding the variable regions of the heavy and light chains of a murine antibody specific for the human TfR were cloned and a human chimera (gamma1, kappa) was produced. A gene fusion was created by joining the 3' end of the coding region o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::863814ed625d2fc2f8dcb069488a31f9
https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<123::aid-jnr1>3.0.co

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Residues critical for H-L disulfide bond formation in human IgA1 and IgA2

Autor: K R Chintalacharuvu, S L Morrison

Publikováno v: The Journal of Immunology. 157:3443-3449

There are two subclasses of human IgA, IgA1 and IgA2. IgA2 exists as two known allotypes, IgA2 m(1) and IgA2 m(2) with a recently reported novel IgA2 (IgA2(n)) possibly representing a third allotype. The variants of human IgA differ in their H and L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf4c382a1a6c5c05a62686e99a10e130
https://doi.org/10.4049/jimmunol.157.8.3443

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In vivo properties of an IgG3-IL-2 fusion protein. A general strategy for immune potentiation

Autor: E T Harvill, J M Fleming, S L Morrison

Publikováno v: The Journal of Immunology. 157:3165-3170

In this report, we describe a strategy for enhancing the immunogenicity of a wide variety of Ags by linking them to IL-2 via an IgG3-IL-2 fusion protein with high affinity for a convenient hapten Ag, dansyl (DNS; N,N-dimethyl-1-aminonaphthalene-5-sul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55bf90cdbde4bec1dfe9120bf075751f
https://doi.org/10.4049/jimmunol.157.7.3165

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Addition of a mu-tailpiece to IgG results in polymeric antibodies with enhanced effector functions including complement-mediated cytolysis by IgG4

Autor: R I Smith, M J Coloma, S L Morrison

Publikováno v: The Journal of Immunology. 154:2226-2236

The 18-amino acid carboxyl-terminal tailpiece from IgM (mutp) has now been added to the carboxyl-termini of IgG1, IgG2, IgG3, and IgG4 constant regions to produce recombinant IgM-like IgGs. Polymeric IgGs obtained by this approach possess up to six F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4bf0c5a69a715347db4f52a965bb0e8
https://doi.org/10.4049/jimmunol.154.5.2226

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Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study

Autor: Dick J. Drost, S. L. Morrison-Stewart, R. J. Rylett, R T Thompson, Peter C. Williamson, Thomas J. Carr, Jeffrey A. Stanley

Publikováno v: Schizophrenia Research. 13:209-215

Membrane phospholipid metabolism was studied with 31P magnetic resonance spectroscopy in the left dorsal prefrontal cortex of 19 male, medicated, schizophrenic patients and compared to 18 normal male controls matched in age, education and parental ed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5b5d6517fb12d78b8e868629a2a61a
https://doi.org/10.1016/0920-9964(94)90044-2

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Structure-function studies of anti-3-fucosyllactosamine (Le(x)) and galactosylgloboside antibodies

Autor: J G Snyder, Q Dinh, S L Morrison, E A Padlan, M Mitchell, L Y Yu-Lee, D M Marcus

Publikováno v: The Journal of Immunology. 153:1161-1170

We are studying murine mAbs against two carbohydrate epitopes, 3-fucosyllactosamine (Le(x), CD15) and galactosylgloboside. The VH domains of both panels of Ab are encoded by VH441, a member of the X24 family of Ig genes. To evaluate the contribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::702083e9de8d89e6d711af2917c18b9e
https://doi.org/10.4049/jimmunol.153.3.1161

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