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Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment

Autor: M. Mahé, S. Léonce, Aurélie Studeny, John A. Hickman, Laurent Meijer, Isabelle Naime, R. M. Golsteyn, I. Versteege, A. Borgne, M. Magdalena Rodriguez

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2006, 25 (56), pp.7361-72. ⟨10.1038/sj.onc.1209718⟩
Oncogene, 2006, 25 (56), pp.7361-72. ⟨10.1038/sj.onc.1209718⟩

We have studied the role of cyclins and cyclin-dependent kinase (CDK) activity in apoptosis induced by camptothecin (CPT). In this model, 22% of the cells stain for annexin-V at 24 h and then proceed to be 93% positive by 72 h. This time window permi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c612a8b01321712fb6c6677a0824e3f
https://hal.archives-ouvertes.fr/hal-00169380

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1-Amino-substituted 8-hydroxy-4,5-dimethyl-5H-pyrido[4,3-b]indoles with propyl- or methyl substituents at the 9-, and 7,9-positions: synthesis and biological evaluation

Autor: E, Costache, C H, Nguyen, S, Léonce, A, Pierré, G, Atassi, E, Bisagni

Publikováno v: Anti-cancer drug design. 13(4)

The title compounds were synthesized in 9-10 steps in order to compare their cytotoxic properties to that for 1-(3-dimethylaminopropyl)-amino-4,5-dimethyl- 8-hydroxy-5H-pyrido[4,3-b]indole. Whereas the latter is a potent cytotoxic agent, displaying s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05bb0f305902eb9c4b10515a7235312d
https://pubmed.ncbi.nlm.nih.gov/9627673

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Synthesis, properties and biological evaluation of substituted furo[3,2-e] and pyrano[3,2-e]pyrido[4,3-b]indoles

Autor: E, Costache, C H, Nguyen, N, Guilbaud, S, Léonce, A, Pierré, G, Atassi, E, Bisagni

Publikováno v: Anti-cancer drug design. 13(4)

Furo[3,2-e]- and pyrano[3,2-e]pyrido[4,3-b] indoles were synthesized from 1,4,5-trisubstituted 8-hydroxy-5H-pyrido[4,3-b]indoles. The intermediates, 10-chloro-6H-furo[3,2-e]pyrido[4,3-b]indole (11), 10-chloro-2,6-dihydro-1H-furo[3,2-e]pyrido-[4,3-b]i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a4c83831ea19bdd26eb53b9dd8b309f
https://pubmed.ncbi.nlm.nih.gov/9627674

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Flow cytometric evaluation of multidrug-resistance circumvention

Autor: S, Léonce, A, Pierré, G, Atassi

Publikováno v: Bulletin du cancer. 82(2)

Flow cytometry, through the measurement of P-gp expression and function, is an important tool in the characterization of multidrug resistant cell lines used in pharmacology. Furthermore, as a complement to classical in vitro tests, this technique all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c292ea174297efb3b6cf9e48ca02875
https://pubmed.ncbi.nlm.nih.gov/10846527

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Effect of duration of exposure to S9788, cyclosporin A or verapamil on sensitivity of multidrug resistant cells to vincristine or doxorubicin

Autor: V, Pérez, A, Pierré, S, Léonce, M, Anstett, G, Atassi

Publikováno v: Anticancer research. 13(4)

In order to explain the high potency of S9788, a new multidrug resistance modifier currently in clinical development, we investigated its accumulation and retention in sensitive and resistant cells. Our results show that S9788 is 13-fold more accumul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37c35f7f771dfbe2dd2e902b35e2b33f
https://pubmed.ncbi.nlm.nih.gov/8352569

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[In vitro characterization of S9788, a new modulator of multidrug resistance]

Autor: V, Pérez, A, Pierré, S, Léonce, M, Anstett, J F, Prost, G, Atassi

Publikováno v: Bulletin du cancer. 80(4)

S9788, a new triazinoaminopiperidine derivative, was 250-fold more active than verapamil in sensitizing DC-3F/AD cells to actinomycin D. This multidrug-resistance modulating activity of S9788 was confirmed on DC-3F/AD, P388/ADR-10, P388/VCR-20, KB/A1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2dc21e593eab1d0d9b2bed19b4646934
https://pubmed.ncbi.nlm.nih.gov/8173185

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