Výsledky vyhledávání - "S L, Schrier"

Membrane phospholipid asymmetry in human thalassemia

Autor: F A, Kuypers, J, Yuan, R A, Lewis, L M, Snyder, C R, Kiefer, A, Bunyaratvej, S, Fucharoen, L, Ma, L, Styles, K, de Jong, S L, Schrier

Publikováno v: Blood. 91(8)

Phospholipid asymmetry in the red blood cell (RBC) lipid bilayer is well maintained during the life of the cell, with phosphatidylserine (PS) virtually exclusively located in the inner monolayer. Loss of phospholipid asymmetry, and consequently expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::383c685369def2e802dfe3b442b5bbb8
https://pubmed.ncbi.nlm.nih.gov/9531618

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Pathophysiology of the thalassemias. The Albion Walter Hewlett Award presentation

Autor: S L, Schrier

Publikováno v: The Western journal of medicine. 167(2)

The Albion Walter Hewlett Award (named for Professor of Medicine and Chair of the Stanford Department of Medicine 1916-1925) recognizes a role model, accomplished in discovery of the biological sciences and at the same time a consummate and compassio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86d4452775254d5ab895985af4a2d6b8
https://pubmed.ncbi.nlm.nih.gov/9291745

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Abnormal assembly of membrane proteins in erythroid progenitors of patients with beta-thalassemia major

Autor: M, Aljurf, L, Ma, E, Angelucci, G, Lucarelli, L M, Snyder, C R, Kiefer, J, Yuan, S L, Schrier

Publikováno v: Blood. 87(5)

The life threatening anemia in beta-thalassemia major (Cooley's anemia) is characterized by profound intramedullary lysis, the cause of which is incompletely understood. Using marrow obtained from beta thalassemia major patients undergoing allogeneic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d77d968632eaf5ebb8bca6e80b8c956e
https://pubmed.ncbi.nlm.nih.gov/8634456

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The instability of the membrane skeleton in thalassemic red blood cells

Autor: J, Yuan, A, Bunyaratvej, S, Fucharoen, C, Fung, E, Shinar, S L, Schrier

Publikováno v: Blood. 86(10)

The thalassemias are a heterogeneous group of disorders characterized by accumulation either of unmatched alpha or beta globin chains. These in turn cause the intramedullary and peripheral hemolysis that leads to varying anemia. A partial explanation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::590d8070f6aacfe51244449551e75d1e
https://pubmed.ncbi.nlm.nih.gov/7579365

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Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia (Cooley's anemia)

Autor: J, Yuan, E, Angelucci, G, Lucarelli, M, Aljurf, L M, Snyder, C R, Kiefer, L, Ma, S L, Schrier

Publikováno v: Blood. 82(2)

The profound and life-threatening anemia in patients with Cooley's anemia is ascribed primarily to intramedullary hemolysis (ineffective erythropoiesis), the cause of which is obscure. Based on prior morphologic data showing nuclear abnormalities, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ff73d6771a280a9d0ba4a168e3403e3
https://pubmed.ncbi.nlm.nih.gov/8142667

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Globin-chain specificity of oxidation-induced changes in red blood cell membrane properties

Autor: S L, Schrier, N, Mohandas

Publikováno v: Blood. 79(6)

We have previously shown that excess unpaired alpha- and beta-globin chains in severe alpha- and beta-thalassemia interacting with the membrane skeleton induce different changes in membrane properties of red blood cells (RBCs) in these two phenotypes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::601daa3a0f77c1ba7daf0c805aa4d182
https://pubmed.ncbi.nlm.nih.gov/1547347

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Characterization and comparison of the red blood cell membrane damage in severe human alpha- and beta-thalassemia

Autor: R, Advani, S, Sorenson, E, Shinar, W, Lande, E, Rachmilewitz, S L, Schrier

Publikováno v: Blood. 79(4)

The aim of the present work was to understand the pathophysiology of the severe human thalassemias as represented by beta-thalassemia intermedia and hemoglobin (Hb) H (alpha-thalassemia) disease. We have previously shown that the material properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6db99cb2e29f1d4162e94d022eb837a
https://pubmed.ncbi.nlm.nih.gov/1737089

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Oxidative red blood cell membrane injury in the pathophysiology of severe mouse beta-thalassemia

Autor: R, Advani, E, Rubin, N, Mohandas, S L, Schrier

Publikováno v: Blood. 79(4)

In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e95f491d08ccc8919dde2e7bcc82fdb2
https://pubmed.ncbi.nlm.nih.gov/1737090

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