Zobrazeno 1 - 10
of 19
pro vyhledávání: '"S L, Reiner"'
Publikováno v:
The Journal of Immunology. 157:4762-4770
CTLA4 is a cell surface molecule that shares 30% homology with CD28 and binds B7 family members with high affinity. Analysis of surface expression on murine T cells revealed up-regulation after stimulation with anti-CD3 mAb in vitro and further augme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9306b112d94ac9a09d57ea2b1342ebd
https://doi.org/10.4049/jimmunol.157.11.4762
https://doi.org/10.4049/jimmunol.157.11.4762
Publikováno v:
The Journal of Experimental Medicine
The role of CD28-mediated signals in T helper cell maturation is not fully understood. We tested the requirement for costimulation through CD28 in several systems of CD4+, T cell differentiation. In vivo priming of mice with genetic disruption of CD2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2525a07207379ff35b0b3cd1bdc953c4
https://doi.org/10.1084/jem.184.3.803
https://doi.org/10.1084/jem.184.3.803
Publikováno v:
The Journal of Immunology. 153:4142-4148
Infection of inbred strains of mice with Leishmania major is a well-characterized model for analysis of the development of effector CD4+ subsets of the Th1 and Th2 types in vivo. We co-administered a fusion protein, CTLA4Ig, that blocks the CD28-B7 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b06f93f1a4bc23467e1a6025a736c0a
https://doi.org/10.4049/jimmunol.153.9.4142
https://doi.org/10.4049/jimmunol.153.9.4142
Publikováno v:
The Journal of Immunology. 151:2077-2086
CD8+ T cells play an important role in the immunologic control of intracellular pathogens, particularly viruses. Leishmania are obligate intracellular parasites of macrophages in the mammalian host, and previous studies using deletion of CD8+ cells b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe685b5fda8def8fb3ce43172588c6b3
https://doi.org/10.4049/jimmunol.151.4.2077
https://doi.org/10.4049/jimmunol.151.4.2077
Publikováno v:
The Journal of Immunology. 150:5059-5069
Infection of susceptible BALB/c mice with Leishmania major leads to progressive infection with the failure to expand and activate Th1 CD4+ T cells that elaborate IFN-gamma, a critically implicated cytokine for control of disease. We used the recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::377189aff59c27daf79f6826cd2c089b
https://doi.org/10.4049/jimmunol.150.11.5059
https://doi.org/10.4049/jimmunol.150.11.5059
Publikováno v:
The Journal of Immunology. 147:1653-1658
Leishmania major disseminates in genetically susceptible BALB/c mice to cause fatal disease. Progressive infection has been linked to the failure of parasite-specific Th1, IFN-gamma-producing, CD4+ T lymphocytes to expand and direct macrophage activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fc624c35c44e50de526192ba085b4c7
https://doi.org/10.4049/jimmunol.147.5.1653
https://doi.org/10.4049/jimmunol.147.5.1653
Publikováno v:
Infection and Immunity. 65:2448-2450
Mice genetically deficient in the pleiotropic cytokine interleukin-6 (IL-6) exhibit immunodeficiency against viral, bacterial, and fungal pathogens. When challenged with the protozoan parasite Leishmania major, IL-6-deficient mice controlled infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7254f46fe2604367017afada509f1c73
https://doi.org/10.1128/iai.65.6.2448-2450.1997
https://doi.org/10.1128/iai.65.6.2448-2450.1997
Autor:
S D, Pippig, C, Peña-Rossi, J, Long, W R, Godfrey, D J, Fowell, S L, Reiner, M L, Birkeland, R M, Locksley, A N, Barclay, N, Killeen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(12)
CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae6c0b1f3fa313c3f2de90a8d38e3cef
https://pubmed.ncbi.nlm.nih.gov/10586044
https://pubmed.ncbi.nlm.nih.gov/10586044
Autor:
S L, Reiner, R A, Seder
Publikováno v:
Immunity. 11(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fddcdb875e645963ea41966e281e92eb
https://pubmed.ncbi.nlm.nih.gov/10435574
https://pubmed.ncbi.nlm.nih.gov/10435574
Autor:
S L, Reiner, D J, Fowell, N H, Moskowitz, K, Swier, D R, Brown, C R, Brown, C W, Turck, P A, Scott, N, Killeen, R M, Locksley
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(2)
Little is known regarding the diversity of the host T cell response that is required to maintain immunologic control of microbial pathogens. Leishmania major persist as obligate intracellular parasites within macrophages of the mammalian host. Immuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e733a5c5e2286098f62512029005d414
https://pubmed.ncbi.nlm.nih.gov/9551925
https://pubmed.ncbi.nlm.nih.gov/9551925