Zobrazeno 1 - 10
of 19
pro vyhledávání: '"S L, Keely"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 255(3)
Octimibate inhibited ADP- and collagen-induced platelet aggregation in human, rabbit and rat platelet-rich plasma. Washed human platelets treated with octimibate had elevated cyclic AMP (cAMP) levels and cAMP-dependent protein kinase activity. When w
Publikováno v:
Proceedings of the National Academy of Sciences. 72:1501-1504
Rat hearts were perfused with epinephrine and/or 1-methyl-3-isobutylxanthine for 2 min. These agents raised the concentration of cAMP and increased the fraction of cAMP-dependent protein kinase (EC 2.7.1.70) in the active form. However, the content o
Autor:
J R, Carson, H R, Almond, M D, Brannan, R J, Carmosin, S F, Flaim, A, Gill, M M, Gleason, S L, Keely, D W, Ludovici, P M, Pitis
Publikováno v:
Journal of Medicinal Chemistry. 31:630-636
A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the "Langendorff" guinea
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 234:H432-H438
In the isolated perfused rat heart, epinephrine produced a rapid, concentration-dependent increase in cyclic adenosine 3',5'-monophosphate (cAMP), activation of cAMP-dependent protein kinase, activation of phosphorylase, and increase in contractile f
Publikováno v:
Journal of Biological Chemistry. 252:3854-3861
In rabbit heart homogenates about 50% of the cAMP-dependent protein kinase activity was associated with the low speed particulate fraction. In homogenates of rat or beef heart this fraction represented approximately 30% of the activity. The percentag
Publikováno v:
Journal of Biological Chemistry. 250:218-225
In crude extracts of adipose tissue the protein kinase dissociates slowly at 30 degrees into regulatory and catalytic subunits in the presence of 700 mug per ml of histone or 0.5 M NaCl. If the kinase is first dissociated by adding 10 muM adenosine 3
Autor:
S L, Keely, A, Eiring
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 236:H84-H91
The effects of histamine on heart cAMP-dependent protein kinase activity, cAMP levels, phosphorylase activity, and contractile force was investigated in the perfused guinea pig heart. To accurately determine the protein kinase activity ratio in guine
Publikováno v:
Journal of Biological Chemistry. 248:1813-1821
The effects of epinephrine, glucagon, insulin and 1-methyl-3-isobutylxanthine on adenosine 3:5-monophosphate (cAMP)-dependent protein kinase activity were investigated in the perfused rat heart. The conditions for homogenization of heart tissue and a
Autor:
S. F. Flaim, Richard J. Carmosin, P. M. Pitis, F. J. Villani, M. M. Gleason, M. D. Brannan, Harold R. Almond, A. Gill, D. W. Ludovici, S. L. Keely, John R. Carson, M. C. Rebarchak
Publikováno v:
ChemInform. 19
Autor:
J D, Corbin, S L, Keely
Publikováno v:
The Journal of biological chemistry. 252(3)
There is broad species variation in the type of cAMP-dependent protein kinase isozyme present in supernatant fractions of heart homogenates as determined by DEAE-cellulose chromatography, Isozyme I, which elutes at less than 0.1 M NaCl, is predominan