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pro vyhledávání: '"S L, Hockerman"'
Autor:
D P, Becker, G, DeCrescenzo, J, Freskos, D P, Getman, S L, Hockerman, M, Li, P, Mehta, G E, Munie, C, Swearingen
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(20)
A series of alpha-alkyl-alpha-amino-beta-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from10 to1000. S