Výsledky vyhledávání - "S L, Crampton"

Antitumor activity and preliminary drug disposition studies on chartreusin (NSC 5159)

Autor: J P, McGovren, G L, Neil, S L, Crampton, M I, Robinson, J D, Douros

Publikováno v: Cancer research. 37(6)

Chartreusin has exhibited significant therapeutic activity against three experimental mouse tumors (ascitic P388, L1210 leukemia, and B16 melanoma) when tumor cells were inoculated i.p. and drug was administered i.p. In further testing against P388 l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b301619a806d186355c70a63b7ac8df
https://pubmed.ncbi.nlm.nih.gov/870180

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Synergistic combination of menogarol and melphalan and other two drug combinations

Autor: M. Johnson, Bijoy K. Bhuyan, S. L. Crampton, Earl G. Adams

Publikováno v: Investigational new drugs. 3(3)

Menogarol is a new anthracycline undergoing phase I clinical trial. We report here the lethality after 2 hr exposure to 2 drug combinations of menogarol and several antitumor agents. A new statistical procedure was used to identify synergistic combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d9b25a8102c86257fd9d9add85350e
https://pubmed.ncbi.nlm.nih.gov/2933360

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CC-1065 (NSC 298223), a most potent antitumor agent: kinetics of inhibition of growth, DNA synthesis, and cell survival

Autor: B K, Bhuyan, K A, Newell, S L, Crampton, D D, Von Hoff

Publikováno v: Cancer research. 42(9)

CC-1065 (NSC 298223) is the most cytotoxic agent tested against cells in culture in our laboratory. The 50% lethal doses for exponentially growing B16 melanoma and Chinese hamster ovary cells were 0.44 and 0.14 ng/ml, respectively, as compared to 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1512f689d387aeb0c1cf953c02d80510
https://pubmed.ncbi.nlm.nih.gov/7105029

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Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture

Autor: B K, Bhuyan, C L, Blowers, S L, Crampton, K D, Shugars

Publikováno v: Cancer research. 41(1)

Nogalamycin is an anthracycline antibiotic which was markedly cytotoxic in vitro and was active against several tumor systems in vivo. We compare here the lethality of several nogalamycin analogs against Chinese hamster ovary (CHO), mouse leukemia (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38753cd0384f33e4ec4ae14518d8c599
https://pubmed.ncbi.nlm.nih.gov/7448758

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Chronic cardiotoxicity studies in rabbits with 7-con-O-methylnogarol, a new anthracycline antitumor agent

Autor: J P, McGovren, G L, Neil, R H, Denlinger, T L, Hall, S L, Crampton, J A, Swenberg

Publikováno v: Cancer research. 39(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc0f5fce6c16c54a71d47b2041fcd388
https://pubmed.ncbi.nlm.nih.gov/498112

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Effect of 7-con-O-methylnogarol on DNA synthesis, survival, and cell cycle progression of Chinese hamster ovary cells

Autor: E G, Adams, S L, Crampton, B K, Bhuyan

Publikováno v: Cancer research. 41(12 Pt 1)

The effect of 7-con-O-methylnogarol (7-OMEN) on the survival of exponentially growing and plateau-phase Chinese hamster ovary cells was determined in a cloning assay. After 2 hr of exposure, the 50% lethal dose for exponential and plateau-phase cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc7dc4da439c06bc0eb7881d2fbb453f
https://pubmed.ncbi.nlm.nih.gov/6458356

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Intracellular uptake of 7-con-o-methylnogarol and adriamycin by cells in culture and its relationship to cell survival

Autor: B K, Bhuyan, J P, McGovren, S L, Crampton

Publikováno v: Cancer research. 41(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3e339f2f23a84da57bf6d8cd7eaaf0b
https://pubmed.ncbi.nlm.nih.gov/6450639

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Biochemical and cellular effects of didemnins A and B

Autor: S L, Crampton, E G, Adams, S L, Kuentzel, L H, Li, G, Badiner, B K, Bhuyan

Publikováno v: Cancer research. 44(5)

Didemnins are a new class of cyclic depsipeptides in which didemnin A is the major component, didemnin B the minor component, and a trace of didemnin C is present. Didemnin B was more potent than was didemnin A against B16 melanoma and P388 leukemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09a460607f8643901b3280d070ec787a
https://pubmed.ncbi.nlm.nih.gov/6713383

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Cell cycle effects of CC-1065

Autor: B K, Bhuyan, S L, Crampton, E G, Adams

Publikováno v: Cancer research. 43(9)

CC-1065 is the most potent antitumor agent tested in our laboratory. It is lethal to B16 and CHO cells and to a variety of human tumors in the clonogenic assay at 1 ng/ml and is effective against L1210 leukemia and B16 melanoma in vivo at 1 to 50 mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::038b9d1fad4a083e448cceb1194a144a
https://pubmed.ncbi.nlm.nih.gov/6871861

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