Zobrazeno 1 - 10
of 716
pro vyhledávání: '"S Kotecha"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The rarity of the mesenchymal stem cell (MSC) population poses a significant challenge for MSC research. Therefore, these cells are often expanded in vitro, prior to use. However, long-term culture has been shown to alter primary MSC propert
Externí odkaz:
https://doaj.org/article/874aeef689b74746bb326812c11f9731
Autor:
Nicola R. Mason, Hilary Cahill, Yonatan Diamond, Karen McCleary, Rishi S. Kotecha, Glenn M. Marshall, Marion K. Mateos
Publikováno v:
Therapeutic Advances in Hematology, Vol 15 (2024)
Children with Down syndrome (DS) are at increased risk of developing haematological malignancies, in particular acute megakaryoblastic leukaemia and acute lymphoblastic leukaemia. The microenvironment established by abnormal haematopoiesis driven by
Externí odkaz:
https://doaj.org/article/37574d0975dc4d6cbe533e3444df707a
Autor:
Tim Spelman, Elizabeth Williams, Rishi S Kotecha, Rachel Conyers, Andreas Halman, Claire Moore, Tayla Stenta, Ben Felmingham, Lane Collier, Dhrita Khatri, Roxanne Dyas, Sophie Jessop, Marion K Mateos, Jesse Swen, David A Elliott
Publikováno v:
BMJ Open, Vol 14, Iss 5 (2024)
Introduction DNA-informed prescribing (termed pharmacogenomics, PGx) is the epitome of personalised medicine. Despite international guidelines existing, its implementation in paediatric oncology remains sparse.Methods and analysis Minimising Adverse
Externí odkaz:
https://doaj.org/article/4da7ddc3784e4dbca556abc4b8bf9c7f
Autor:
Zsolt Sebestyen, Jürgen Kuball, Maud Plantinga, Anja Krippner-Heidenreich, S Nierkens, Ester Dunnebach, Vania Lo Presti, Olaf T Heidenreich, Angelo Meringa, Alice van Velzen, Aida Valera Moreira, Ronald W Stam, Rishi S Kotecha, Annelisa Cornel, Niek P van Til
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Hematopoietic cell transplantation (HCT) is an effective treatment for pediatric patients with high-risk, refractory, or relapsed acute myeloid leukemia (AML). However, a large proportion of transplanted patients eventually die due to rela
Externí odkaz:
https://doaj.org/article/201ace7f9fc54b5eb4254af5c2cc872c
Autor:
Denitza Mironova, Chitra M. Saraswati, Peter Downie, Chow Yee Lai, Eleanor Cook, Vickyanne Carruthers, Perla Moukhaiber, Fiona Molloy, Joshua Serov, Elizabeth McKinnon, Frank Alvaro, Michael Osborn, Tamas Revesz, Tim Prestidge, Siobhan Cross, Caroline M. Bateman, Andrew S. Moore, Seong Lin Khaw, Marion K. Mateos, Rishi S. Kotecha
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/a941785cc3ea4f9c81cf14648077fcdb
Autor:
Shannon L. Carey-Smith, Maryam H. Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Sang Lin, Jesse D. Armitage, Vivien T. Nguyen, Kathryn Bentley, Jette Ford, Sajla Singh, Joyce Oommen, Anouchka P. Laurent, Thomas Mercher, John D. Crispino, Andrew P. Montgomery, Michael Kassiou, Thierry Besson, Emmanuel Deau, Laurent Meijer, Laurence C. Cheung, Rishi S. Kotecha, Sébastien Malinge
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/af0891557ec64135b02d85e7951931e8
Autor:
Clarissa E. Schilstra, Karen McCleary, Joanna E. Fardell, Mark W. Donoghoe, Emma McCormack, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla-Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Marion K. Mateos, Toby N. Trahair
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Pediatric acute lymphoblastic leukemia (ALL) therapy is accompanied by treatment-related toxicities (TRTs) and impaired quality of life. In Australia and New Zealand, children with ALL are treated with either Children’s Oncology
Externí odkaz:
https://doaj.org/article/17592b5db9b04671b967107c72d358c2
Autor:
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S. Kotecha, Mark N. Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K. Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and pe
Externí odkaz:
https://doaj.org/article/7fee3de7cd6b4b10b237a1df0b62b1d6
Autor:
Ilesh S Kotecha, Disha Alkeshbhai Vasavada, Parveen Kumar, Lubna Mohammed Rafik Nerli, Deepak Sachidanand Tiwari, Dipesh V Parmar
Publikováno v:
Asian Journal of Social Health and Behavior, Vol 5, Iss 2, Pp 63-67 (2022)
Introduction: India approved the “Covishield” vaccine for emergency use and began the first vaccination drive from January 16, 2021. As the new coronavirus disease-2019 (COVID-19) vaccine was developed within a short period, public acceptance for
Externí odkaz:
https://doaj.org/article/34872edbe409416ab115e824b0b0bb82
Autor:
Anastasia M. Hughes, Vincent Kuek, Joyce Oommen, Grace-Alyssa Chua, Maria van Loenhout, Sebastien Malinge, Rishi S. Kotecha, Laurence C. Cheung
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack the BMM, altering its functioning and estab
Externí odkaz:
https://doaj.org/article/c46e2c8ee89a4ad795e3a7318874e88f