Zobrazeno 1 - 10
of 33
pro vyhledávání: '"S Kaye Spratt"'
Autor:
Sarah A Figley, Yang Liu, Spyridon K Karadimas, Kajana Satkunendrarajah, Peter Fettes, S Kaye Spratt, Gary Lee, Dale Ando, Richard Surosky, Martin Giedlin, Michael G Fehlings
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96137 (2014)
Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal cord barrier disruption. Vascular endothelial growth factor-A (VEGF-A) is
Externí odkaz:
https://doaj.org/article/324faa1c054a4a2b9902448c459c4e79
Autor:
Travis Wood, Dawn A. Maier, Andrea L. Brennan, Gabriela Plesa, Carl H. June, Gary Lee, Julio Cotte, Elena E. Perez, Bruce L. Levine, S. Kaye Spratt, Carmine Carpenito, Richard G. Carroll, Zhaohui Zheng, Philip D. Gregory, Michael C. Holmes, Gwendolyn Binder-Scholl, James L. Riley, Dale Ando, Shuguang Jiang
Publikováno v:
Human Gene Therapy. 24:245-258
Since HIV requires CD4 and a co-receptor, most commonly C-C chemokine receptor 5 (CCR5), for cellular entry, targeting CCR5 expression is an attractive approach for therapy of HIV infection. Treatment of CD4(+) T cells with zinc-finger protein nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b68a33458b8b8b8f5d12362c1f8cf7
https://doi.org/10.1089/hum.2012.172
https://doi.org/10.1089/hum.2012.172
Autor:
H Steve, Zhang, Dingang, Liu, Yan, Huang, Stefan, Schmidt, Reed, Hickey, Dmitry, Guschin, Haili, Su, Ion S, Jovin, Mike, Kunis, Sarah, Hinkley, Yuxin, Liang, Linda, Hinh, S Kaye, Spratt, Casey C, Case, Edward J, Rebar, Barbara E, Ehrlich, Barbara, Ehrlich, Philip D, Gregory, Frank J, Giordano
Publikováno v:
Molecular Therapy
Selective inhibition of disease-related proteins underpins the majority of successful drug–target interactions. However, development of effective antagonists is often hampered by targets that are not druggable using conventional approaches. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf6d75f77ecc7bd1ea7a45b7b9474c4
http://europepmc.org/articles/PMC3412484
http://europepmc.org/articles/PMC3412484
Autor:
Nicholas M. Boulis, Brenten L. Heeke, Brooke R. Snyder, Bethwel Raore, Thais Federici, Colin K. Franz, S. Kaye Spratt, Igor Radovitskiy, Michele A. Kliem, Emily M. Barrow
Publikováno v:
Amyotrophic Lateral Sclerosis. 12:331-339
Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron loss leading to paralysis and death. Vascular endothelial growth factor (VEGF) has angiogenic, neurotrophic, and neuroprotective properties, and has preserved neuromuscular function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639f4c7bc017f5047c845802b3532de6
https://doi.org/10.3109/17482968.2011.574142
https://doi.org/10.3109/17482968.2011.574142
An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury
Autor:
Yang Liu, Dale Ando, Gary Lee, Richard T. Surosky, S. Kaye Spratt, Michael G. Fehlings, Sarah A. Figley
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 2, Pp 384-393 (2010)
Spinal cord injury (SCI) leads to local vascular disruption and progressive ischemia, which contribute to secondary degeneration. Enhancing angiogenesis through the induction of vascular endothelial growth factor (VEGF)-A expression therefore constit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faef85d976d6aa6b40b00c758c602e51
http://www.sciencedirect.com/science/article/pii/S0969996109003040
http://www.sciencedirect.com/science/article/pii/S0969996109003040
Autor:
Edward J. Rebar, Pascal J. Goldschmidt-Clermont, Chunming Dong, S. Kaye Spratt, Bruce Klitzman, Christopher D. Kontos, Casey C. Case, Brian H. Johnstone, Qunsheng Dai, Keith L. March, Jianhua Huang, Brian H. Annex, Joseph Rokovich
Publikováno v:
Circulation. 110:2467-2475
Background— Therapeutic angiogenesis seeks to promote blood vessel growth to improve tissue perfusion. Vascular endothelial growth factor (VEGF) exists in multiple isoforms. We investigated an engineered zinc finger–containing transcription facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75c6e1f9069f4a07ac74f502bf5eab0
https://doi.org/10.1161/01.cir.0000145139.53840.49
https://doi.org/10.1161/01.cir.0000145139.53840.49
Autor:
Andrew C. Jamieson, Lei Zhang, Casey C. Case, Reed Hickey, David F. Meoli, Anjali K. Nath, Frank J. Giordano, Bingliang Chen, Edward J. Rebar, Yan Huang, Lei Xu, S. Kaye Spratt, Alan P. Wolffe, Yuxin Liang, Sameer K. Nath
Publikováno v:
Nature Medicine. 8:1427-1432
The relationship between the structure of zinc-finger protein (ZFP) transcription factors and DNA sequence binding specificity has been extensively studied. Advances in this field have made it possible to design ZFPs de novo that will bind to specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854016e44f67fbf57ad82c1cdc265379
https://doi.org/10.1038/nm795
https://doi.org/10.1038/nm795
Autor:
Tammy Kielian, Timothy M. Miller, Linas Padegimas, Rachel W. Fallet, Amy Aldrich, Adam David, S. Kaye Spratt
Publikováno v:
Molecular Genetics and Metabolism. 120:S127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35492053b7766c3f83a84570d4d1ef0f
https://doi.org/10.1016/j.ymgme.2016.11.332
https://doi.org/10.1016/j.ymgme.2016.11.332
Autor:
Gwendolyn Binder-Scholl, Ronald G. Collman, Michael Kalos, Ian Frank, Philip D. Gregory, Geoff Nichol, Bruce L. Levine, S. Kaye Spratt, Dale G. Ando, Michael C. Holmes, Pablo Tebas, Winson Tang, Gabriela Plesa, Shelley Wang, Gary Lee, Carl H. June, David Stein, Martin Giedlin, Wei-Ting Hwang, Richard T. Surosky
Publikováno v:
The New England journal of medicine. 370(10)
CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We investigated whether site-specific modification of the gene ("gene editing")--in this case, the infusion of autologous CD4 T cells in which the CCR5 gene was rendered permanently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb7c58fab510bbcdaaeb784d273080f
https://pubmed.ncbi.nlm.nih.gov/25035879
https://pubmed.ncbi.nlm.nih.gov/25035879
Autor:
Peter Fettes, Yang Liu, Dale Ando, Martin Giedlin, Gary Lee, Spyridon K. Karadimas, S. Kaye Spratt, Kajana Satkunendrarajah, Sarah A. Figley, Richard T. Surosky, Michael G. Fehlings
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96137 (2014)
PLoS ONE
PLoS ONE
Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal cord barrier disruption. Vascular endothelial growth factor-A (VEGF-A) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01554652345389ce13283970f7ad2516
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24846143/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24846143/pdf/?tool=EBI