Zobrazeno 1 - 10
of 48
pro vyhledávání: '"S K Pierce"'
Autor:
E Blackman, A Buell, J R Sullivan, S Urato, M Miller, W H Watson, S K Pierce, N E Curtis, M G Kallins, K M F Bourque, J M Newcomb
Publikováno v:
Integrative Organismal Biology
Synopsis A number of nudibranchs, including Melibe engeli and Melibe pilosa, harbor symbiotic photosynthetic zooxanthellae. Melibe leonina spends most of its adult life on seagrass or kelp, capturing planktonic organisms in the water column with a la
Publikováno v:
The Journal of Immunology. 157:5487-5495
HLA-DM has been shown in vitro to catalyze the release of invariant chain (Ii) derived peptides from the peptide-binding groove of class II molecules, thereby facilitating the binding of antigenic peptides. Previous studies showed that at steady stat
Publikováno v:
The Journal of Immunology. 155:4255-4263
The processing and presentation of Ag by B lymphocytes are initiated by Ag binding to the B cell Ag receptor (BCR). Using subcellular fractionation, we recently identified a compartment in B cells in which functional, processed Ag-class II complexes
Publikováno v:
The Journal of Immunology. 155:3759-3768
The HLA-DM alpha and HLA-DM beta genes encode a nonpolymorphic, class II-like molecule that functions by an as yet undefined mechanism in the assembly of processed antigen-HLA class II complexes. Mutant cells that fail to express HLA-DM are deficient
Intracellular transport of invariant chain-MHC class II complexes to the peptide-loading compartment
Publikováno v:
The Journal of Immunology. 155:2984-2992
Th cells recognize peptide fragments of foreign Ags bound to MHC class II molecules. Upon synthesis in the endoplasmic reticulum, the alpha- and beta-chains of the class II molecules rapidly associate with invariant chains (li). The dissociation of l
Autor:
A E Faassen, S K Pierce
Publikováno v:
The Journal of Immunology. 155:1737-1745
Th cells bind to peptide-class II complexes presented on B cell surfaces. Recent evidence indicates that upon cross-linking, class II molecules transduce signals that modulate a variety of B cell functions. One possible function of class II signaling
Autor:
W L Niebling, S K Pierce
Publikováno v:
The Journal of Immunology. 150:2687-2697
Helper T-cell recognition of Ag requires that the Ag be processed and presented by class II-expressing Ag-presenting cells. Processing involves the introduction of Ag into acidic compartments where proteolysis occurs producing peptides that bind to t
Publikováno v:
The Journal of Immunology. 146:500-506
A 72/74-kDa peptide binding protein (PBP72/74) was previously described which plays a role in the processing and/or presentation of Ag, possibly by facilitating the association of processed Ag with the MHC class II molecules. PBP72/74 was recently sh
Autor:
X Xu, S K Pierce
Publikováno v:
The Journal of Immunology. 155:1652-1654
Autor:
S, Malapati, S K, Pierce
Publikováno v:
European journal of immunology. 31(12)
Cholesterol- and sphingolipid-rich membrane microdomains termed lipid rafts appear to play a central role in B cell activation. In mature B cells, signaling through the B cell antigen receptor(BCR) is initiated from within rafts and leads to activati