Zobrazeno 1 - 10
of 15
pro vyhledávání: '"S K, Spratt"'
Publikováno v:
Neuroscience. 92:185-196
As a potential treatment for Parkinson's disease, viral vector-mediated over-expression of striatal L-aromatic amino acid decarboxylase was tested in an attempt to facilitate the production of therapeutic levels of dopamine after peripheral L-dihydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dffd319d1ce827cdd44a974367dd941
https://doi.org/10.1016/s0306-4522(98)00741-6
https://doi.org/10.1016/s0306-4522(98)00741-6
Autor:
Delphine Bohl, L. K. Cohen, M. Van Roey, K. G. Rendahl, Brian A. Donahue, Richard O. Snyder, Olivier Danos, Stuart E. Leff, Ronald J. Mandel, S. K. Spratt, G. R. Otten
Publikováno v:
Nature Biotechnology. 16:757-761
Control of gene expression is important to gene therapy for purposes of both dosing and safety. In vivo regulation of gene expression was demonstrated following co-injection of two separate recombinant adeno-associated virus vectors, one encoding an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceaca1fb86f556b7bef85d6b324318e
https://doi.org/10.1038/nbt0898-757
https://doi.org/10.1038/nbt0898-757
Publikováno v:
Experimental Neurology. 151:249-264
To investigate the biochemical requirements for in vivo L-DOPA production by cells genetically modified ex vivo in a rat model of Parkinson's disease (PD), rat syngeneic 9L gliosarcoma and primary Fischer dermal fibroblasts (FDFs) were transduced wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f184f9827f68b4e271a41aa1fdafe285
https://doi.org/10.1006/exnr.1998.6803
https://doi.org/10.1006/exnr.1998.6803
Autor:
C Lagarde, Delphine Bohl, B Sloan, Richard O. Snyder, S K Spratt, Lawrence K. Cohen, Olivier Danos, B Kaspar
Publikováno v:
Human Gene Therapy. 8:1891-1900
Recombinant adeno-associated virus (rAAV) vectors were evaluated for gene transfer into the skeletal muscle of adult immunocompetent mice. A study using a vector encoding nuclear localized beta-galactosidase (rAAV-nls-lacZ) examined: (i) the efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3f7721fa89e91510a9bb74fc35e733
https://doi.org/10.1089/hum.1997.8.16-1891
https://doi.org/10.1089/hum.1997.8.16-1891
Autor:
Leonard Meuse, Allen M. Gown, D Nagy, L. K. Cohen, Richard O. Snyder, Olivier Danos, Arthur R. Thompson, Carol H. Miao, Mark A. Kay, Brian Winther, Gijsbert A. Patijn, S. K. Spratt
Publikováno v:
Nature Genetics. 16:270-276
Haemophilia B, or factor IX deficiency, is a X-linked recessive disorder that occurs in about one in 25,000 males, and severely affected people are at risk for spontaneous bleeding into numerous organs. Bleeding can be life-threatening or lead to chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec3c141f54da4f210bcce5fe528a42b
https://doi.org/10.1038/ng0797-270
https://doi.org/10.1038/ng0797-270
Autor:
S K Spratt, Sang Su Oh, Stacey A. Sakowski, Eva L. Feldman, J S Lunn, Norman D. Hogikyan, S B Heavener, Kevin Fung
Publikováno v:
Gene therapy. 16(11)
Engineered zinc-finger protein transcription factors induce the expression of endogenous genes and can be remotely delivered using adenoviral vectors. One such factor, Ad-32Ep65-Flag, targets and induces expression of vascular endothelial growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110d8759cdb9264a8cda674a4e7bf1c2
https://pubmed.ncbi.nlm.nih.gov/19727131
https://pubmed.ncbi.nlm.nih.gov/19727131
Autor:
P Q, Liu, E J, Rebar, L, Zhang, Q, Liu, A C, Jamieson, Y, Liang, H, Qi, P X, Li, B, Chen, M C, Mendel, X, Zhong, Y L, Lee, S P, Eisenberg, S K, Spratt, C C, Case, A P, Wolffe
Publikováno v:
The Journal of biological chemistry. 276(14)
We have mapped conserved regions of enhanced DNase I accessibility within the endogenous chromosomal locus of vascular endothelial growth factor A (VEGF-A). Synthetic zinc finger protein (ZFP) transcription factors were designed to target DNA sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04da16db317a83949c81d32031e04981
https://pubmed.ncbi.nlm.nih.gov/11145970
https://pubmed.ncbi.nlm.nih.gov/11145970
Autor:
L, Zhang, S K, Spratt, Q, Liu, B, Johnstone, H, Qi, E E, Raschke, A C, Jamieson, E J, Rebar, A P, Wolffe, C C, Case
Publikováno v:
The Journal of biological chemistry. 275(43)
We have targeted the activation of an endogenous chromosomal locus including the human erythropoietin gene using synthetic transcription factors. These transcription factors are targeted to particular DNA sequences in the 5'-flanking region of the er
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cd133793756f0dece753b3464043106
https://pubmed.ncbi.nlm.nih.gov/10913152
https://pubmed.ncbi.nlm.nih.gov/10913152
Autor:
B A, Donahue, J G, McArthur, S K, Spratt, D, Bohl, C, Lagarde, L, Sanchez, B A, Kaspar, B A, Sloan, Y L, Lee, O, Danos, R O, Snyder
Publikováno v:
The journal of gene medicine. 1(1)
Recombinant adeno-associated viral (rAAV) vectors are capable of long-term expression of secreted and intracellular proteins following delivery to muscle, liver, and the central nervous system. In this study, we have evaluated subcutaneous injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b11e7da0aea88929361aa8de185a7d4f
https://pubmed.ncbi.nlm.nih.gov/10738583
https://pubmed.ncbi.nlm.nih.gov/10738583
Autor:
D.G. Clevenger, Richard O. Snyder, Ronald J. Mandel, S. K. Spratt, Stuart E. Leff, Fred H. Gage
Publikováno v:
Experimental neurology. 155(1)
Nerve growth factor (NGF) has been shown to support the survival of axotomized medial septal cholinergic neurons after aspirative lesions of the fimbria-fornix (FF). This survival effect has been achieved utilizing intraventricular and intraparenchym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818a4d14b82bd8b70759b8a007ca5a02
https://pubmed.ncbi.nlm.nih.gov/9918705
https://pubmed.ncbi.nlm.nih.gov/9918705