Zobrazeno 1 - 6
of 6
pro vyhledávání: '"S K, Kirkman"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(7)
Bromfenac (Duract(R)), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d585123d6338b0ef1a602f0f234586b4
https://pubmed.ncbi.nlm.nih.gov/9660857
https://pubmed.ncbi.nlm.nih.gov/9660857
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31bd0be38de0a189ee6bd260800cb9a2
https://pubmed.ncbi.nlm.nih.gov/8149881
https://pubmed.ncbi.nlm.nih.gov/8149881
Publikováno v:
Advances in experimental medicine and biology. 197
Hydrolysis and rearrangement (isomerization by acyl migration) of oxaprozin glucuronide are greatly accelerated by plasma and human serum albumin. Albumin accounts for all the hydrolytic activity in plasma and no esterase is involved. The isomeric es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73279efc302508f73f7eaebdfce3e548
https://pubmed.ncbi.nlm.nih.gov/3766273
https://pubmed.ncbi.nlm.nih.gov/3766273
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 6(4)
Following intragastric doses of 14C-oxaprozin to beagle dogs and rhesus monkeys, oxaprozin was rapidly absorbed and was essentially the only drug-related substance in the plasma for at least 24 hr. Recovery of radioactivity in the excreta was 87% in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e92962008491b24a803ff3b7d61734b
https://pubmed.ncbi.nlm.nih.gov/28928
https://pubmed.ncbi.nlm.nih.gov/28928
Publikováno v:
Biological Reactive Intermediates III ISBN: 9781468451368
Acyl glucuronides are major metabolites of many carboxylic acids including drugs, various chemicals, as well as endogenously formed compounds such as bilirubin and benzoic acid. Because of their susceptibility to nucleophilic attack acyl glucuronides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d74d64966c11ce84bff5b6bcd6db8fde
https://doi.org/10.1007/978-1-4684-5134-4_42
https://doi.org/10.1007/978-1-4684-5134-4_42
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 10(6)
Excretion of 3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid (I) and its metabolites was studied in rats, beagle dogs, and rhesus monkeys given 20-mg/kg doses of 14C-labeled drug. The urine of rhesus monkeys contained two metabolites in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17c45ba69f2cbd9c60511b4947aeaa8e
https://pubmed.ncbi.nlm.nih.gov/6130907
https://pubmed.ncbi.nlm.nih.gov/6130907