Výsledky vyhledávání

Akademický článek

Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase

Autor: Zuodong Sun, Cooper S. Jamieson, Masao Ohashi, K. N. Houk, Yi Tang

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Pericyclase enzymes are an expanding family of enzymes. Here, the authors identify the norbornene synthase SdnG, a pericyclase for the intramolecular Diels-Alder reaction between a cyclopentadiene and an olefinic dienophile to form the sordaricin nor

Externí odkaz: https://doaj.org/article/7d335afb622f40cc83bd744b9064bc56

Zobrazit plný text záznamu

Enzymatic cis-Decalin Formation in Natural Product Biosynthesis

Autor: Masao Ohashi, Dan Tan, Jiayan Lu, Cooper S. Jamieson, Daiki Kanayama, Jiahai Zhou, K. N. Houk, Yi Tang

Publikováno v: Journal of the American Chemical Society. 145:3301-3305

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4d80a30bf22114111e78731e793809d
https://doi.org/10.1021/jacs.2c12854

Zobrazit plný text záznamu

Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates

Autor: Runze Mao, Daniel J. Wackelin, Cooper S. Jamieson, Torben Rogge, Shilong Gao, Anuvab Das, Doris Mia Taylor, K. N. Houk, Frances H. Arnold

In nature and synthetic chemistry, stereoselective [2+1] cyclopropanation is the most prevalent strategy for the synthesis of chiral cyclopropanes, a class of key pharmacophores in pharmaceuticals and bioactive natural products. One of the most exten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac552d0bf48a8e968ace926188b9a4a8
https://doi.org/10.21203/rs.3.rs-2802333/v1

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Computational Design of a Tetrapericyclic Cycloaddition and the Nature of Potential Energy Surfaces with Multiple Bifurcations

Autor: Ana Martin-Somer, Xiao-Song Xue, Cooper S. Jamieson, Yike Zou, K.N. Houk

Publikováno v: Journal of the American Chemical Society, vol 145, iss 7

An ambimodal transition state (TS) that leads to formation of four different pericyclic reaction products ([4 + 6]-, [2 + 8]-, [8 + 2]-, and [6 + 4]-cycloadducts) without any intervening minima has been designed and explored with DFT computations and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa2269123f9dbf857d8c18f62f42eac
https://escholarship.org/uc/item/3pk2t9kg

Zobrazit plný text záznamu

Catalytic mechanism and

Autor: Michio, Sato, Shinji, Kishimoto, Mamoru, Yokoyama, Cooper S, Jamieson, Kazuto, Narita, Naoya, Maeda, Kodai, Hara, Hiroshi, Hashimoto, Yuta, Tsunematsu, Kendall N, Houk, Yi, Tang, Kenji, Watanabe

Publikováno v: Nat Catal

We have previously reported the identification of CghA, a proposed Diels–Alderase responsible for the formation of the bicyclic octalin core of the fungal secondary metabolite Sch210972. Here we show the crystal structure of the CghA–product comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d802ea738ce3644380e46ac987ace20
https://pubmed.ncbi.nlm.nih.gov/35873532

Zobrazit plný text záznamu

Sulfide Oxidation by 2,6-Bis[hydroxyl(methyl)amino]-4-morpholino-1,3,5-triazinatodioxomolybdenum(VI): Mechanistic Implications with DFT Calculations for a New Class of Molybdenum(VI) Complex

Autor: Pierre Moënne-Loccoz, Jordan A. M. Gonzalez, Cayden X. Bullock, Ellie A. Draves, Louis Y. Kuo, Cooper S. Jamieson, Buck L. H. Taylor

Publikováno v: Inorganic Chemistry. 60:7762-7772

Sulfide oxidation is accomplished by a new class of dioxomolybdenum(VI) catalyst (1) that uses the tridentate 2,6-bis[hydroxyl(methyl)amino]-4-morpholino-1,3,5-triazine ligand to form a five-coordinate molybdenum(VI) center. Resonance Raman spectra s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74b57edd4ad31ebf07364974d23d1e9
https://doi.org/10.1021/acs.inorgchem.1c00145

Zobrazit plný text záznamu

Computational Exploration of the Mechanism of Critical Steps in the Biomimetic Synthesis of Preuisolactone A, and Discovery of New Ambimodal (5 + 2)/(4 + 2) Cycloadditions

Autor: Xiao-Song Xue, Kendall N. Houk, Alexander J. E. Novak, Shuming Chen, Cooper S. Jamieson, Dirk Trauner, Hong Zhang

Publikováno v: Journal of the American Chemical Society. 143:6601-6608

Computational studies with ωB97X-D density functional theory of the mechanisms of the steps in Trauner's biomimetic synthesis of preuisolactone A have elaborated and refined mechanisms of several unique processes. An ambimodal transition state has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8a774e21f1535c091c1c746fd7f49a
https://doi.org/10.1021/jacs.1c01856

Zobrazit plný text záznamu

Cycloadditions of Cyclopentadiene and Cycloheptatriene with Tropones: All Endo-[6+4] Cycloadditions Are Ambimodal

Autor: Arkajyoti Sengupta, Cooper S. Jamieson, K. N. Houk

Publikováno v: Journal of the American Chemical Society. 143:3918-3926

The cycloadditions of cyclopentadiene and cycloheptatriene with tropone are some of the earliest published examples of [6+4] cycloaddition reactions. We report quantum mechanical studies (ωB97X-D and DLPNO-CCSD(T)) of transition structures and produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d30d7fc8bd28b2735c9f312cc9869fb
https://doi.org/10.1021/jacs.0c13401

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání