Zobrazeno 1 - 10 of 41 pro vyhledávání: '"S J R Heales"'
1
Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity
Autor: S. J. R. Heales, Matthew E. Gegg, John B. Clark
Publikováno v: Brain Research. 1036:1-6
The antioxidant glutathione (GSH) plays an important role in protecting the mitochondrial electron transport chain (ETC) from damage by oxidative stress in astrocytes and neurones. Neurones co-cultured with astrocytes have greater GSH levels, compare
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743401a55450909c2c4f80bea02a40fc
https://doi.org/10.1016/j.brainres.2004.11.064
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2
Diagnostic Value of Succinate Ubiquinone Reductase Activity in the Identification of Patients with Mitochondrial DNA Depletion
Autor: S. J. R. Heales, P. Guthrie, S Rahman, J-W. Taanman, John M. Land, James V. Leonard, Iain P. Hargreaves
Publikováno v: Journal of Inherited Metabolic Disease. 25:7-16
Mitochondrial DNA (mtDNA) depletion syndrome (McKusick 251880) is characterized by a progressive quantitative loss of mtDNA resulting in severe mitochondrial dysfunction. A diagnosis of mtDNA depletion can only be confirmed after Southern blot analys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c36f920b60cc2a3793ad21f956792dc
https://doi.org/10.1023/a:1015104910239
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3
Peroxynitrite Anion Stimulates Arginine Release from Cultured Rat Astrocytes
Autor: Vega-Agapito, Angeles Almeida, S. J. R. Heales, J M Medina, Juan P. Bolaños
Publikováno v: Journal of Neurochemistry. 73:1446-1452
The biosynthesis of the physiological messenger nitric oxide (*NO) in neuronal cells is thought to depend on a glial-derived supply of the *NO synthase substrate arginine. To expand our knowledge of the mechanism responsible for this glial-neuronal i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbdf0c2c88e8600669b48cbf43bf311
https://doi.org/10.1046/j.1471-4159.1999.0731446.x
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6
The diagnosis of carnitine palmitoyltransferase II deficiency is now possible in small skeletal muscle biopsies
Autor: Iain P. Hargreaves, Simon E. Olpin, J. A. Morgan-Hughes, S. J. R. Heales, John M. Land
Publikováno v: Journal of Inherited Metabolic Disease. 23:352-354
Carnitine palmitoyltransferase II (CPT II) converts acylcarnitine esters to the corresponding acyl-CoA derivatives within mitochondria prior to β-oxidation. CPT II deficiency (McKusick 255110) may present early in life, with patients displaying hypo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d91bd7c571411ee791475d88cac8d13
https://doi.org/10.1023/a:1005627113617
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7
Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice
Autor: Josie McConnell, Malgorzata S. Martin-Gronert, Anthea Rowlerson, Lucilla Poston, Iain P. Hargreaves, Denise S. Fernandez-Twinn, Piran Shelley, Susan E. Ozanne, S. J. R. Heales
We recently reported insulin resistance in adult offspring of obese C57BL/6J mice. We have now evaluated whether parameters of skeletal muscle structure and function may play a role in insulin resistance in this model of developmental programming. Ob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3b6b070362288d42865c9e6614fae9
https://europepmc.org/articles/PMC2739782/
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8
Cerebrospinal fluid nitrite plus nitrate correlates with tetrahydrobiopterin concentration
Autor: Laura Canevari, S. J. R. Heales, M. P. Brand, John M. Land, John B. Clark, Keith Hyland
Publikováno v: Journal of Inherited Metabolic Disease. 22:221-223
Within the central nervous system (CNS), tetrahydrobiopterin (BH 4 ) is an essential cofactor for the aromatic amino acid monoxygenases. Consequently, inborn errors of BH 4 metabolism result in hyperphenylalaninaemia and impaired dopamine and seroton
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56201c0b29e317619982551d8a98f81a
https://doi.org/10.1023/a:1005540828706
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9
Mitochondrial cytochrome c release: a factor to consider in mitochondrial disease?
Autor: S. J. R. Heales, John M. Land, Mls Oppenheim, Iain P. Hargreaves, Simon Pope
Publikováno v: Journal of inherited metabolic disease. 32(2)
The pathogenesis of mitochondrial disorders has largely focused on the impairment of cellular energy metabolism. However, mitochondrial dysfunction has also been implicated as a factor in the initiation of apoptosis due to the translocation of cytoch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c1e832c7bcc6fe346ac65a1e902052
https://pubmed.ncbi.nlm.nih.gov/19169843
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10
Nitric oxide accelerates the degradation of tetrahydrobiopterin but not total neopterin in cerebrospinal fluid; potential implications for the assessment of tetrahydrobiopterin metabolism
Autor: S J R Heales, A A J Lam
Publikováno v: Annals of clinical biochemistry. 44(Pt 4)
Assessment of total neopterin and tetrahydrobioterin (BH4) concentrations in cerebrospinal fluid (CSF) can be used to identify potential disorders of BH4 biosynthesis. In this study, we demonstrate that exposure of CSF to nitric oxide leads to an acc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94ec911501f14f71a46f5e01924f0e0
https://pubmed.ncbi.nlm.nih.gov/17594789
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