Zobrazeno 1 - 10
of 25
pro vyhledávání: '"S J Mihic"'
Autor:
Jonathan T. Pierce, S. J. Mihic, Ashley E. Philpo, Elliott J. Brecht, Luisa L. Scott, Sangeetha Iyer, N. S. Wu, Richard W. Aldrich, Joseph P. Walton
Publikováno v:
Scientific Reports
Large conductance calcium-activated (BK) channels are broadly expressed in neurons and muscle where they modulate cellular activity. Decades of research support an interest in pharmaceutical applications for modulating BK channel function. Here we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01325f6e7b444734d7f75c455438ceed
https://doi.org/10.1038/srep42433
https://doi.org/10.1038/srep42433
Publikováno v:
British Journal of Pharmacology. 118:378-384
1. The effects of n-alcohols on GABAA and glutamate receptor systems were examined, and in vitro effectiveness was compared with in vivo effects in mice and tadpoles. We expressed GABAA, NMDA, AMPA, or kainate receptors in Xenopus oocytes and examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d796229676c9dd86158a777bb8378ce1
https://doi.org/10.1111/j.1476-5381.1996.tb15413.x
https://doi.org/10.1111/j.1476-5381.1996.tb15413.x
Publikováno v:
The FASEB Journal. 9:1454-1462
Molecular cloning of cDNAs coding for ligand-gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions. Many laboratories have used these techniques recently to study actions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f198f6b9a58ea555cfe7592f387db1
https://doi.org/10.1096/fasebj.9.14.7589987
https://doi.org/10.1096/fasebj.9.14.7589987
Publikováno v:
Journal of Biological Chemistry. 269:32768-32773
Incorporation of the gamma 2 subunit into gamma-aminobutyric acid type A (GABAA) receptors is required for the expression of benzodiazepine pharmacology, but the regions of the subunit responsible for benzodiazepine actions have not been defined. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a831e22d5c116c4dcc5abe207445d3a6
https://doi.org/10.1016/s0021-9258(20)30057-0
https://doi.org/10.1016/s0021-9258(20)30057-0
Publikováno v:
Journal of Biological Chemistry. 269:19546-19552
Microtubules are present at postsynaptic densities in brain and are proposed to be involved in anchoring neurotransmitter receptor clusters at postsynaptic membranes. However, the influence of microtubules on gamma-aminobutyric acidA (GABAA) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f639f2e8feef5c3468c52fba0896ff4
https://doi.org/10.1016/s0021-9258(17)32203-2
https://doi.org/10.1016/s0021-9258(17)32203-2
Publikováno v:
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 21:3-8
Eight anticonvulsant drugs – including clonazepam, diazepam and phenobarbital – were tested for their effects on GABA-stimulated chloride uptake in rat cerebral cortical microsacs (unfiltered synaptoneurosomes). “Mid” and “high” therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142d45f3c7afe00d81ed61c28ef8e78a
https://doi.org/10.1017/s031716710004868x
https://doi.org/10.1017/s031716710004868x
Autor:
R. A. Harris, S. J. Mihic
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(1)
It is remarkable that a simple two-carbon molecule like ethyl alcohol produces the many neurological, physiological, and societal effects that result from alcohol (ethanol) use and misuse. It is the least potent of all drugs, requiring concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69633dbbc6d03b06f369d897a7cfda2f
https://pubmed.ncbi.nlm.nih.gov/14625373
https://pubmed.ncbi.nlm.nih.gov/14625373
Autor:
S J Mihic, Donald W. Bowden, Ann L. Craddock, Sallyanne C. Fossey, Josyf C. Mychaleckyj, Paul A. Dawson
Publikováno v:
Molecular genetics and metabolism. 74(1-2)
We have carried out a detailed sequence and functional analysis of a novel human facilitative glucose transporter, designated GLUT10, located in the Type 2 diabetes-linked region of human chromosome 20q12–13.1. The GLUT10 gene is located between D2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b1b74cdc3fd104b15197e7365cde2c
https://pubmed.ncbi.nlm.nih.gov/11592815
https://pubmed.ncbi.nlm.nih.gov/11592815
Publikováno v:
Molecular pharmacology. 57(6)
Inhalable solvents possess significant abuse liability and produce many of the neurobehavioral effects typically associated with central nervous system-depressant agents, including motor incoordination, anxiolysis, and the elicitation of signs of phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc5da1dc5298732bfe9ecf5cd9e41d34
https://pubmed.ncbi.nlm.nih.gov/10825391
https://pubmed.ncbi.nlm.nih.gov/10825391
Publikováno v:
Drug and alcohol dependence. 51(1-2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09601d548c00a512990d52ffcf0cb722
https://pubmed.ncbi.nlm.nih.gov/9716937
https://pubmed.ncbi.nlm.nih.gov/9716937