Výsledky vyhledávání

LPS inhibits the intracellular growth of Legionella pneumophila in thioglycolate elicited murine peritoneal macrophages by iron-dependent, tryptophan-independent, oxygen-independent, and arginine-independent mechanisms

Autor: Thomas W. Klein, Yoshimasa Yamamoto, S J Gebran, Herman Friedman, Mitsugu Tomioka, Ray Widen, Catherine Newton

Publikováno v: Journal of Leukocyte Biology. 57:80-87

Thioglycolate-elicited murine macrophages from genetically susceptible A/J mice activated with lipopolysaccharide (LPS) and infected with Legionella pneumophila in vitro evince marked inhibition of intracellular growth of this bacterium. The mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151c954a4c7569b65bae293dcf0dca19
https://doi.org/10.1002/jlb.57.1.80

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Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron(III)

Autor: Thomas W. Klein, Yoshimasa Yamamoto, Cathy Newton, Herman Friedman, S J Gebran

Publikováno v: Infection and Immunity. 62:3197-3205

A/J mouse macrophages infected with Legionella pneumophila and treated with gamma interferon (IFN-gamma) in vitro developed potent antimicrobial activity. This antilegionella activity was independent of the macrophage capacity to generate reactive ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f37aec03ec55cd2ca8272ce12f6b4a4
https://doi.org/10.1128/iai.62.8.3197-3205.1994

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Macrophage permissiveness for Legionella pneumophila growth modulated by iron

Autor: Thomas W. Klein, Cathy Newton, Raymond Widen, Yoshimasa Yamamoto, S J Gebran, Herman Friedman

Publikováno v: Infection and Immunity. 62:564-568

We have investigated the modulation of iron in two populations of macrophages which differ in susceptibility to Legionella pneumophila intracellular proliferation. Previously, we reported that thioglycolate-elicited peritoneal macrophages obtained fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc83b0d2ec5c0c10cb834943d5b38637
https://doi.org/10.1128/iai.62.2.564-568.1994

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Differences and similarities in permissive A/J versus non-permissive BALB/c murine macrophages infected with Legionella pneumophila: the role of iron

Autor: Thomas W. Klein, Shannon McHugh, Cathy Newton, S J Gebran, Yoshimasa Yamamoto, Herman Friedman

Publikováno v: FEMS immunology and medical microbiology. 9(1)

Legionella pneumophila, a facultative intracellular pathogen, replicates within and kills thioglycolate-elicited (TG) macrophages from A/J mice, while growth is inhibited in TG macrophages from BALB/c mice which show no impaired viability. The role o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57fa1d077713d64fadc0a70a3147b6e
https://pubmed.ncbi.nlm.nih.gov/7920466

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A rapid colorimetric assay for evaluating Legionella pneumophila growth in macrophages in vitro

Autor: Yoshimasa Yamamoto, Herman Friedman, Thomas W. Klein, Cathy Newton, S J Gebran

Publikováno v: Journal of clinical microbiology. 32(1)

A rapid colorimetric technique for in vitro quantitation of Legionella pneumophila intracellular proliferation in macrophages is described. The assay is based on the electron transport activity of metabolically active L. pneumophila. The yellow tetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b863a273d35d99fb5bb7d58c1db9ed2
https://pubmed.ncbi.nlm.nih.gov/8126166

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