Zobrazeno 1 - 10
of 13
pro vyhledávání: '"S J Charlton"'
Autor:
S, Nijmeijer, H F, Vischer, F, Sirci, S, Schultes, H, Engelhardt, C, de Graaf, E M, Rosethorne, S J, Charlton, R, Leurs
Publikováno v:
British journal of pharmacology. 170(1)
The histamine H₄ receptor, originally thought to signal merely through Gαi proteins, has recently been shown to also recruit and signal via β-arrestin2. Following the discovery that the reference antagonist indolecarboxamide JNJ 7777120 appears t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a7d46bf69c8eaf6fc5d0491bb738749
https://pubmed.ncbi.nlm.nih.gov/23351115
https://pubmed.ncbi.nlm.nih.gov/23351115
Publikováno v:
British journal of pharmacology. 167(4)
DiscoverRx's PathHunter™ assay measures GPCR agonist potency, via the recruitment of β-arrestin, independent of the subtype of G(α) protein activated. This assay is frequently used in drug discovery although little is known about the agonist phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f010770347a9d413f400c7d494710c6
https://pubmed.ncbi.nlm.nih.gov/22577868
https://pubmed.ncbi.nlm.nih.gov/22577868
Publikováno v:
British journal of pharmacology. 159(7)
We have previously shown that SB265610 (1-(2-bromo-phenyl)-3-(7-cyano-3H-benzotriazol-4-yl)-urea) behaves as an allosteric, inverse agonist at the C-X-C chemokine (CXCR)2 receptor. The aim of this study was to determine whether SB265610, in addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::700376459ac09c87f67748da844038d2
https://pubmed.ncbi.nlm.nih.gov/20233217
https://pubmed.ncbi.nlm.nih.gov/20233217
Publikováno v:
Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy. 206:167-175
Measurements of in-cylinder mixture strength, during compression and combustion, were made on a natural gas engine using a novel fast-response flame ionization detector (FID). The Collings FID was found to be an effective instrument for measuring the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e3a7b9544474308ba01fef81aa1f90
https://doi.org/10.1243/pime_proc_1992_206_027_02
https://doi.org/10.1243/pime_proc_1992_206_027_02
Publikováno v:
Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering. 205:263-272
The paper describes a computational and experimental study of the application of advanced ceramic materials for thermal insulation of the swirl chamber of the passenger car IDI diesel engine. Four ceramic materials, having a wide range of physical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e981f2c4a624216727a15530f251f700
https://doi.org/10.1243/pime_proc_1991_205_182_02
https://doi.org/10.1243/pime_proc_1991_205_182_02
Publikováno v:
British journal of pharmacology. 124(4)
1. Previous studies have shown that ATP and UTP are able to stimulate phospholipase C (PLC) and proliferation in cultured aortic smooth muscle cells. Here we set out to characterize the receptor responsible, and investigate a possible role for p42 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28eeca512bcb20725e831128570248f3
https://pubmed.ncbi.nlm.nih.gov/9690862
https://pubmed.ncbi.nlm.nih.gov/9690862
Publikováno v:
British journal of pharmacology. 120(6)
1. We have previously shown that both suramin and pyridoxal-phosphate-6-azophenyl-2',4' disulphonic acid (PPADS) act as antagonists at transfected P2Y1 receptors. Here we show that under certain experimental conditions these two P2 antagonists can en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0bacf1c7432680c4446a85ed62e60b1
https://pubmed.ncbi.nlm.nih.gov/9134216
https://pubmed.ncbi.nlm.nih.gov/9134216
Publikováno v:
SAE Technical Paper Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbbafa25d2c068004c7a28f6591a1b74
https://doi.org/10.4271/931097
https://doi.org/10.4271/931097
Publikováno v:
SAE Technical Paper Series.
A new hydraulic cam follower with variable valve timing (VVT) properties is described. Experimental results show that the point of closure of the valve may be delayed as a linear function of engine speed without external control. No other parameter o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d668407e2485cc78bb0a9c34a49f21f9
https://doi.org/10.4271/930823
https://doi.org/10.4271/930823
Autor:
S J Charlton
Publikováno v:
Proceedings of the Institution of Mechanical Engineers, Part A: Power and Process Engineering. 198:231-239
The paper discusses the potential of a conventional high-speed diesel engine for operation at increased power output (+ 50 per cent), using readily available components and ancillaries, whilst retaining the traditional virtues of good thermal efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab012c14aec277fc488dc36d32bc9be1
https://doi.org/10.1243/pime_proc_1984_198_026_02
https://doi.org/10.1243/pime_proc_1984_198_026_02