Zobrazeno 1 - 10
of 10
pro vyhledávání: '"S J, Sarsfield"'
Autor:
S H Ridley, S J Sarsfield, J C Lee, H F Bigg, T E Cawston, D J Taylor, D L DeWitt, J Saklatvala
Publikováno v:
The Journal of Immunology. 158:3165-3173
The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d5d1888a156c39a8d56bc9751a9ce97
https://doi.org/10.4049/jimmunol.158.7.3165
https://doi.org/10.4049/jimmunol.158.7.3165
Publikováno v:
The Journal of Immunology. 148:474-479
The inhibitory effect of pertussis toxin on the action of IL-1 has been investigated. The toxin inhibited IL-1-induced production of IL-2 mRNA and protein in EL4 cells. The B oligomer of the toxin, which was shown to be devoid of ADP-ribosylating act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa42b069452ecd570a05cdcadf7beb44
https://doi.org/10.4049/jimmunol.148.2.474
https://doi.org/10.4049/jimmunol.148.2.474
Publikováno v:
Rheumatology (Oxford, England). 45(9)
OBJECTIVES: To develop a proteomics approach to study changes in the secreted protein levels of primary human chondrocytes after stimulation by the pro-inflammatory cytokines interleukin-1 and oncostatin M. METHODS: Using both the primary human artic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a17823e6f7c71939b3894620035ebf
https://pubmed.ncbi.nlm.nih.gov/16567360
https://pubmed.ncbi.nlm.nih.gov/16567360
Autor:
S H, Ridley, S J, Sarsfield, J C, Lee, H F, Bigg, T E, Cawston, D J, Taylor, D L, DeWitt, J, Saklatvala
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(7)
The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3da34c609750027190f15eb6217d3d4a
https://pubmed.ncbi.nlm.nih.gov/9120270
https://pubmed.ncbi.nlm.nih.gov/9120270
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 148(2)
The inhibitory effect of pertussis toxin on the action of IL-1 has been investigated. The toxin inhibited IL-1-induced production of IL-2 mRNA and protein in EL4 cells. The B oligomer of the toxin, which was shown to be devoid of ADP-ribosylating act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43ee709c2992624cf915aa0fd2d49710
https://pubmed.ncbi.nlm.nih.gov/1309558
https://pubmed.ncbi.nlm.nih.gov/1309558
Publikováno v:
Biochemical Journal. 209:337-344
Both human synovial tissue in culture and lectin-stimulated mononuclear leucocytes produced a protein that induced proteoglycan resorption in explants of bovine nasal cartilage and human articular cartilage. On gel filtration the protein had Mr 16000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1418c295f7598c2c8961e21534be7ae3
https://doi.org/10.1042/bj2090337
https://doi.org/10.1042/bj2090337
Publikováno v:
The Journal of Experimental Medicine
Two forms of interleukin 1 (IL-1) were purified to homogeneity from the culture supernatants of pig buffy coat leukocytes stimulated with concanavalin A. The two proteins had identical Mr of 21,000 on sodium dodecyl sulfate-polyacrylamide gel electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acfae5fd72198e994c1e7ca415e392e
https://pubmed.ncbi.nlm.nih.gov/2995535
https://pubmed.ncbi.nlm.nih.gov/2995535
Autor:
S J Sarsfield, J Saklatvala
Mononuclear cells from pig blood, when cultured in the presence of lectins (concanavalin A or phytohaemagglutinin), release a factor that induces resorption of proteoglycan in explants of live bovine nasal cartilage. The factor had mol.wt. 20000 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e36f64f09174983285b1b0214efbfb
https://europepmc.org/articles/PMC1158104/
https://europepmc.org/articles/PMC1158104/
Publikováno v:
The Biochemical journal. 215(2)
Catabolin, a protein that causes proteoglycan resorption in explants of living cartilage, was purified to homogeneity from culture medium conditioned by culturing buffy-coat leucocytes from 60 litres of pig blood in the presence of concanavalin A. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e706cd297165098ba40cec1bc45ed23
https://pubmed.ncbi.nlm.nih.gov/6651767
https://pubmed.ncbi.nlm.nih.gov/6651767
Publikováno v:
ResearcherID
Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6c80c3529568f0f249bade8d53ad63
https://pubmed.ncbi.nlm.nih.gov/6097218
https://pubmed.ncbi.nlm.nih.gov/6097218