Zobrazeno 1 - 10
of 23
pro vyhledávání: '"S J, Roffey"'
Autor:
Anthony Harrison, Paul Morgan, John D. Davis, Katherine S. Fenner, Alison Betts, Pierre Comby, Kevin Beaumont, A Edgington, S. J. Roffey
Publikováno v:
Drug Metabolism and Disposition. 32:197-204
4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline (UK-294,315) is an antagonist of the human alpha1-adrenoceptor and exhibits nonlinear oral pharmacokinetics in humans. Superproportional increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d8914164fd0df56f85b9013da513b
https://doi.org/10.1124/dmd.32.2.197
https://doi.org/10.1124/dmd.32.2.197
Publikováno v:
Clinical Infectious Diseases. 37:728-732
We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d92816e6080f2cf2fc30b8332c1570
https://doi.org/10.1086/377131
https://doi.org/10.1086/377131
Autor:
D. K. Walker, Dennis A. Smith, S. Cole, Pierre Comby, Angus N. R. Nedderman, S. J. Roffey, S. G. Jezequel, N. Wood, D. Gibson
Publikováno v:
Drug Metabolism and Disposition. 31:731-741
Voriconazole is a new triazole antifungal agent with potent, wide-spectrum activity. Its pharmacokinetics and metabolism have been studied in mouse, rat, rabbit, dog, guinea pig, and humans after single and multiple administration by both oral and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f088a764c97c96ecb6744f1a12911d77
https://doi.org/10.1124/dmd.31.6.731
https://doi.org/10.1124/dmd.31.6.731
Publikováno v:
Xenobiotica. 33:541-560
1. UK-240,455 ((+) 6,7-dichloro-5-[N-(2-hydroxyethyl)methanesulphonamido]-2,3 (1H,4H)-quinoxalinedione) is a potent, selective N-methyl D-aspartate (NMDA) glycine site antagonist that is being evaluated for the potential treatment of stroke. 2. UK-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6231afa7e85e0ab73966fe030560a9c6
https://doi.org/10.1080/0049825031000085988
https://doi.org/10.1080/0049825031000085988
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 22:773-780
A selective method for the determination of sulphobutylether-beta-cyclodextrin (SBECD) in human plasma has been developed and validated over the range 4-200 microg ml(-1). SBECD is extracted from plasma using end-capped cyclohexyl solid phase extract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e9cb500fec71a55f425c1c0d3d18e9
https://doi.org/10.1016/s0731-7085(99)00283-6
https://doi.org/10.1016/s0731-7085(99)00283-6
Publikováno v:
Drug metabolism reviews. 39(1)
Mass balance excretion studies in laboratory animals and humans using radiolabeled compounds represent a standard part of the development process for new drugs. From these studies, the total fate of drug-related material is obtained: mass balance, ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68c7a9f4afeaf6efb7a307ef8eb1fc7
https://pubmed.ncbi.nlm.nih.gov/17364879
https://pubmed.ncbi.nlm.nih.gov/17364879
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 35(1)
The clinical pharmacokinetics of midazolam have been extensively studied, due to its high clearance by CYP3A4 and sensitivity to drug–drug interactions. In order to investigate the potential to model drug–drug interactions with midazolam in the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3c15266be70338f01ce88e6b15bb38
https://pubmed.ncbi.nlm.nih.gov/15030887
https://pubmed.ncbi.nlm.nih.gov/15030887
Publikováno v:
International journal of clinical pharmacology and therapeutics. 36(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10f30bdd8160edb24ca4745999e408ee
https://pubmed.ncbi.nlm.nih.gov/9520152
https://pubmed.ncbi.nlm.nih.gov/9520152
Autor:
Atzrodt, Jens1 Jens.Atzrodt@sanofi.com, Derdau, Volker1 Volker.Derdau@sanofi.com, Kerr, William J.2 w.kerr@strath.ac.uk, Reid, Marc2 marc.reid.100@strath.ac.uk
Publikováno v:
Angewandte Chemie. 2/12/2018, Vol. 130 Issue 7, p1774-1802. 29p.
Autor:
Allan, G. A.1 (AUTHOR) gill.allan@pfizer.com, Gedge, J. I.1 (AUTHOR), Nedderman, A. N. R.1 (AUTHOR), Roffey, S. J.1 (AUTHOR), Small, H. F.1 (AUTHOR), Webster, R.1 (AUTHOR)
Publikováno v:
Xenobiotica. May2006, Vol. 36 Issue 5, p399-418. 20p. 2 Charts, 12 Graphs.