Zobrazeno 1 - 10
of 61
pro vyhledávání: '"S J, Korsmeyer"'
Publikováno v:
Journal of Virology. 71:9753-9763
We have investigated the relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1 (HIV-1), by employing diverse strategies to inhibit P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7098a73566b85871b043890429eadda
https://doi.org/10.1128/jvi.71.12.9753-9763.1997
https://doi.org/10.1128/jvi.71.12.9753-9763.1997
Publikováno v:
The Journal of Immunology. 156:2143-2154
CBA/N mice carry an X-linked immunodeficiency (xid) due to a point mutation in the Bruton's tyrosine kinase (btk) gene. xid mice have a smaller peripheral B cell pool than normal animals, lack CD5+ B cells (B1), and are hyporesponsive to mitogenic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33238afe9a0e30f9e98bc41995a108cb
https://doi.org/10.4049/jimmunol.156.6.2143
https://doi.org/10.4049/jimmunol.156.6.2143
Publikováno v:
The Journal of Immunology. 155:3453-3463
Normal B cells responsive to thymus independent-type 1 Ags (TI-1) are resistant to low doses of ionizing radiation in vivo (200-300 cGy), compared with TI-1 responsive B cells of mice with the CBA/N X-linked immunodeficiency (xid). This difference in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0839e93bd57e76681d9017c0922e901
https://doi.org/10.4049/jimmunol.155.7.3453
https://doi.org/10.4049/jimmunol.155.7.3453
Publikováno v:
American Journal of Physiology-Renal Physiology. 268:F73-F81
Apoptosis of the developing metanephric kidney plays an important role in renal organogenesis. The bcl-2 is an oncogene that inhibits apoptotic cell death in a variety of settings. The bcl-2 (-/-) mice complete embryonic development but, in contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20003ce94337ed5e8b425b6c76a2244
https://doi.org/10.1152/ajprenal.1995.268.1.f73
https://doi.org/10.1152/ajprenal.1995.268.1.f73
Autor:
Mel Greaves, John C. Reed, S J Korsmeyer, Dudley T. Goodhead, S Krajewski, S. J. Marsden, Eric G. Wright, S D Griffiths
Publikováno v:
The Journal of Experimental Medicine
We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that of clonogenic mature B cells and myeloid precursors to alpha-particles from plutonium-238 and X radiation. All three populations are rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60320feeb7852a9a3f097723a791f374
http://europepmc.org/articles/PMC2191526
http://europepmc.org/articles/PMC2191526
Publikováno v:
Scopus-Elsevier
The protooncogene product Bcl-2 is an integral membrane protein that functions as a suppressor of programmed cell death. It contains a single predicted transmembrane segment located at its COOH terminus. Here, we show that the transmembrane domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdbc2e74f8d905df81be46d058e1c13
https://doi.org/10.1016/s0021-9258(19)74386-5
https://doi.org/10.1016/s0021-9258(19)74386-5
Publikováno v:
Molecular and Cellular Biology. 13:5469-5478
The goal of this study was to determine whether it will be feasible to study the expression of a large, human gene, such as the BCL2 proto-oncogene, by DNA transfection. The BCL2 proto-oncogene is 230 kb in size and is deregulated in tumor cells by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::705c54cf4ac57c67f1b9f1f512ac1072
https://doi.org/10.1128/mcb.13.9.5469
https://doi.org/10.1128/mcb.13.9.5469
Publikováno v:
Blood. 82:1080-1085
The chromosomal translocation, t(4;11)(q21;q23), is the most common type of 11q23 chromosomal abnormality, being highly prevalent in infant acute leukemias and associated with a poor prognosis. The t(4;11) results in the fusion of an 11q23 gene (MLL,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e2f6ed412f6930231d1bf524b53f5c
https://doi.org/10.1182/blood.v82.4.1080.bloodjournal8241080
https://doi.org/10.1182/blood.v82.4.1080.bloodjournal8241080
Autor:
S. J. Korsmeyer, Nyla A. Heerema, Chien-Shing Chen, G. H. Reaman, Peter H. Domer, G. D. Hammond, J. H. Kersey, Poul H. Sorensen
Publikováno v:
Blood. 81:2386-2393
Acute lymphoblastic leukemia (ALL) in infants generally shows distinctive biologic features and has a poor prognosis. Cytogenetic studies indicate that many infant leukemias have chromosome 11q23 translocations. Because of these findings and the dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f388b4aa20dec4f8f1bc38bc8431b97
https://doi.org/10.1182/blood.v81.9.2386.bloodjournal8192386
https://doi.org/10.1182/blood.v81.9.2386.bloodjournal8192386
Publikováno v:
The Journal of Immunology. 144:3602-3610
The t(14;18) of human follicular B cell lymphoma translocates the Bcl-2 gene into the Ig H chain locus and markedly deregulates Bcl-2 expression. We sought to determine if Bcl-2 could be directly implicated in a growth-factor pathway. Consequently, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e67db6397092d6fe6699eff0f53d2bd2
https://doi.org/10.4049/jimmunol.144.9.3602
https://doi.org/10.4049/jimmunol.144.9.3602