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Autor: Graham D. Spacey, S. J. Hirst, Martin John Slater, Robert W. Bonser, Iain J. Uings

Publikováno v: Biochemical Pharmacology. 55:261-271

A quantitative assay for measuring the autophosphorylation of platelet-derived growth factor (PDGF) receptors in intact vascular smooth muscle cells has been developed and used to screen for novel tyrosine kinase (TK) inhibitors. Several novel inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3174834219f78b43a2fbe5314460128b
https://doi.org/10.1016/s0006-2952(97)00460-7

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Under reporting of sleepiness and driving impairment in patients with sleep apnoea/hypopnoea syndrome

Autor: Neil J. Douglas, Heather M. Engleman, William S. J. Hirst

Publikováno v: Journal of Sleep Research. 6:272-275

Under reporting of symptoms by patients with sleep apnoea/hypopnoea syndrome (SAHS) has been reported anecdotally, but investigation of the prevalence or determinants of this is limited. To assess this, repeated ratings in 99 patients with sleep apno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0da2eeb1bf2730de78c26a43aa716b9
https://doi.org/10.1111/j.1365-2869.1997.00272.x

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Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type

Autor: Michael A. Saunders, Magdi H. Yacoub, Maria G. Belvisi, El-Bdaoui Haddad, Jane A. Mitchell, Peter J. Barnes, S. J. Hirst

Publikováno v: British Journal of Pharmacology. 120:910-916

Cyclo-oxygenase (COX) is the enzyme that converts arachidonic acid to prostaglandin H2 (PGH2) which can then be further metabolized to prostanoids which modulate various airway functions. COX exists in at least two isoforms. COX-1 is expressed consti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2da86e1922cec372cacf53293f4e49f3
https://doi.org/10.1038/sj.bjp.0700963

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Ion channels in freshly isolated and cultured human bronchial smooth muscle cells

Autor: Jeremy P.T. Ward, S. J. Hirst, V. A. Snetkov

Publikováno v: Experimental Physiology. 81:791-804

Voltage-gated ion currents were studied in human bronchial airway smooth muscle (ASM) cells. Proliferating or growth-arrested cells in culture were compared with freshly isolated cells. Three types of charybdotoxin (ChTX)-sensitive K+ channel were ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c5b0fe8de2b46f0df12575a3e554f0
https://doi.org/10.1113/expphysiol.1996.sp003977

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PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells

Autor: S. J. Hirst, Charles H. C. Twort, P. J. Barnes

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 270:L415-L428

The effect of recombinant platelet-derived growth factor (PDGF) isoforms (PDGF-AA, -BB and -AB) on mitogenesis of human cultured airway smooth muscle (ASM) was examined using the MTT-reduction assay and [3H]thymidine incorporation. Results were corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfed01b692e856530ce343dd0bf3f028
https://doi.org/10.1152/ajplung.1996.270.3.l415

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Preparation of cultured airway smooth muscle for study of intracellular element concentrations by X-ray microanalysis: Comparison of whole cells with cryosections

Autor: A. Warley, H. B. Cammish, S. J. Hirst, K. P. B. Cracknell, Charles H. C. Twort, Jeremy P.T. Ward

Publikováno v: Journal of Microscopy. 175:143-153

Methods for growing and preparing smooth muscle cells, isolated from rabbit trachealis, for X-ray microanalysis studies are presented. The cells are grown on Pioloform-covered gold grids supported on Thermanox coverslips. This provides a growth-compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da15205f06a5484de0bb7211afd9d889
https://doi.org/10.1111/j.1365-2818.1994.tb03477.x

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Quantifying Proliferation of Cultured Human and Rabbit Airway Smooth Muscle Cells in Response to Serum and Platelet-derived Growth Factor

Autor: Peter J. Barnes, Charles H. C. Twort, S. J. Hirst

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 7:574-581

Development of suitable methods for the quantification of the proliferative response of airway smooth muscle (ASM) cells in culture will assist the investigation of the cellular mechanisms underlying the hyperplasia and hypertrophy of ASM as seen in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9899dd3ed9304cf29d46a0a9d65b47c
https://doi.org/10.1165/ajrcmb/7.6.574

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beta(2)-adrenoceptor agonists inhibit release of eosinophil-activating cytokines from human airway smooth muscle cells

Autor: M P, Hallsworth, C H, Twort, T H, Lee, S J, Hirst

Publikováno v: British journal of pharmacology. 132(3)

1. Airway smooth muscle (ASM) is a potential source of multiple pro-inflammatory cytokines during airway inflammation. beta-Adrenoceptor agonist hyporesponsiveness is a characteristic feature of asthma, and interleukin (IL)-1 beta and tumour necrosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdb6091fd6a058c76daf177028765450
https://pubmed.ncbi.nlm.nih.gov/11159726

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