Transcriptional regulation of the MUC1 mucin gene in colon carcinoma cells by a soluble factor. Identification of a regulatory element

Autor: Tatsuro Irimura, K Shirotani, S J Gendler, J Taylor-Papadimitriou

Publikováno v: Journal of Biological Chemistry. 269:15030-15035

We have investigated a mechanism of the regulation of mucin core polypeptide (MUC1) gene expression, which is induced by a soluble stimulatory factor, in KM12C human colon carcinoma cells. Conditioned media from normal human colon tissues elevated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::829097c38f2d0e0b43c8d97ae5b6b80c
https://doi.org/10.1016/s0021-9258(17)36570-5

A Click-Type Enzymatic Method for Antigen-Adjuvant Conjugation.

Autor: Sun Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China.; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China., Li T; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China., Guo Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China., Sun P; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China., Wu J; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China., Pan C; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China., Wang H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China., Zhu L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China.

Publikováno v: Small methods [Small Methods] 2024 Aug 23, pp. e2401116. Date of Electronic Publication: 2024 Aug 23.

MUC1, the renaissance molecule

Autor: S J, Gendler

Publikováno v: Journal of mammary gland biology and neoplasia. 6(3)

MUC1 is a large, heavily glycosylated mucin expressed on the apical surfaces of most simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory, urinary and reproductive tracts. Although MUC1 was thought to be an epithelia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::055c00b9369cdd9ab40d807407b7bde6
https://pubmed.ncbi.nlm.nih.gov/11547902

Selection and characterization of MUC1-specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells

Autor: J, Gong, V, Apostolopoulos, D, Chen, H, Chen, S, Koido, S J, Gendler, I F, McKenzie, D, Kufe

Publikováno v: Immunology. 101(3)

Mice transgenic for the human MUC1 carcinoma-associated antigen (MUC1.Tg) are tolerant to immunization with MUC1 antigen. Recent studies, however, have demonstrated that immunization of MUC1.Tg mice with fusions of MUC1-positive tumour and dendritic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ae825e16b206e86a5c21c8a54e29f8b
https://pubmed.ncbi.nlm.nih.gov/11106934

Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice

Autor: I K, Klein, S R, Ritland, L J, Burgart, S C, Ziesmer, P C, Roche, S J, Gendler, W E, Karnes

Publikováno v: Cancer research. 60(8)

Members of the protein kinase C (PKC) family appear to play important roles in colorectal carcinogenesis. To investigate the potential involvement of PKC isozymes in adenomatous transformation induced by inactivation of the adenomatous polyposis coli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48d859f94745465874ab390c26f2f147
https://pubmed.ncbi.nlm.nih.gov/10786662