Výsledky vyhledávání - "S J, Freemantle"

Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects

Autor: M J, Spinella, K E, Brigle, S J, Freemantle, E E, Sierra, I D, Goldman

Publikováno v: Biochemical pharmacology. 52(5)

We previously described a methotrexate-resistant L1210 cell line (MTXrA) that lacks a functional reduced folate carrier and does not appreciably express the folate receptor. In the present study, we utilized MTXrA cell lines stably transfected with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15fcba37cde4bce9d81400e8ecdef6f0
https://pubmed.ncbi.nlm.nih.gov/8765468

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Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus

Autor: S M, Taylor, S J, Freemantle, R G, Moran

Publikováno v: Cancer research. 55(24)

The cytotoxicity, and probably the selectivity, of folate antimetabolites depend upon the expression of the enzyme folylpoly-gamma-glutamate synthetase in tumor cells. Evidence for the existence of multiple forms of this enzyme and the need to define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36a678b5249dba0469f3e4cfb43a2c9c
https://pubmed.ncbi.nlm.nih.gov/8521387

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