Zobrazeno 1 - 10
of 29
pro vyhledávání: '"S J, Danishefsky"'
Publikováno v:
Journal of the American Chemical Society. 123(44)
Radicicol (1) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the molecular chaperone Hsp90. Recently, we reported the results of a synthetic program targeting radicicol (1) and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e297804e43372fde38289a46b39766b9
https://pubmed.ncbi.nlm.nih.gov/11686693
https://pubmed.ncbi.nlm.nih.gov/11686693
Autor:
T, Gilewski, G, Ragupathi, S, Bhuta, L J, Williams, C, Musselli, X F, Zhang, W G, Bornmann, M, Spassova, K P, Bencsath, K S, Panageas, J, Chin, C A, Hudis, L, Norton, A N, Houghton, P O, Livingston, S J, Danishefsky
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(6)
The carbohydrate antigen globo H commonly found on breast cancer cells is a potential target for vaccine therapy. The objectives of this trial were to determine the toxicity and immunogenicity of three synthetic globo H-keyhole limpet hemocyanin conj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ee54fea839d3753d4a686f92ca0620
https://pubmed.ncbi.nlm.nih.gov/11248068
https://pubmed.ncbi.nlm.nih.gov/11248068
Autor:
T M, Kamenecka, S J, Danishefsky
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 7(1)
A total synthesis of a structure proposed for himastatin was accomplished. The non-identity of the fully synthetic material with himastatin necessitated a revision of the assigned structure. Confirmation of the revised stereostructure was subsequentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0db805aa892c8c488f7d33e1b8fb1b8
https://pubmed.ncbi.nlm.nih.gov/11205026
https://pubmed.ncbi.nlm.nih.gov/11205026
Autor:
C, Cox, S J, Danishefsky
Publikováno v:
Organic letters. 2(22)
[reaction: see text] We report in this Letter a synthesis of the densely oxygenated CDEF ring system (27) corresponding to that found in the recently discovered antibiotic lactonamycin. The key steps in the synthesis consist of an intramolecular Wess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b07fe65afafcc0a483cf58c4ee6a4486
https://pubmed.ncbi.nlm.nih.gov/11082017
https://pubmed.ncbi.nlm.nih.gov/11082017
Publikováno v:
Ernst Schering Research Foundation workshop. (32)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5d43cc2cbcc13e050da2102a47097ac
https://pubmed.ncbi.nlm.nih.gov/11077604
https://pubmed.ncbi.nlm.nih.gov/11077604
Autor:
P J, Sabbatini, V, Kudryashov, G, Ragupathi, S J, Danishefsky, P O, Livingston, W, Bornmann, M, Spassova, A, Zatorski, D, Spriggs, C, Aghajanian, S, Soignet, M, Peyton, C, O'Flaherty, J, Curtin, K O, Lloyd
Publikováno v:
International journal of cancer. 87(1)
As the initial step in developing carbohydrate-based vaccines for the treatment of ovarian cancer patients in an adjuvant setting, 25 patients were immunized with a Lewis(y) pentasaccharide (Le(y))-keyhole limpet hemocyanin (KLH)-conjugate vaccine to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2d1f69d9e2cf64098d31c6fa5dff99d
https://pubmed.ncbi.nlm.nih.gov/10861456
https://pubmed.ncbi.nlm.nih.gov/10861456
Autor:
J R, Allen, J G, Allen, X F, Zhang, L J, Williams, A, Zatorski, G, Ragupathi, P O, Livingston, S J, Danishefsky
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 6(8)
A new synthesis of the hexasaccharide MBr1 antigen (globo-H) is reported. A revised construction with improved efficiency was necessary because an anti-cancer vaccine containing this antigen is entering phase II and phase III clinical trials for pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5208a07b2253037104f26427cb221550
https://pubmed.ncbi.nlm.nih.gov/10840960
https://pubmed.ncbi.nlm.nih.gov/10840960
Autor:
L A, Martello, H M, McDaid, D L, Regl, C P, Yang, D, Meng, T R, Pettus, M D, Kaufman, H, Arimoto, S J, Danishefsky, A B, Smith, S B, Horwitz
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)
Recently, three natural products have been identified, the epothilones, eleutherobin, and discodermolide, whose mechanism of action is similar to that of Taxol in that they stabilize microtubules and block cells in the mitotic phase of the cell cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0813878ff749289f4bab21b15f3ec335
https://pubmed.ncbi.nlm.nih.gov/10815877
https://pubmed.ncbi.nlm.nih.gov/10815877
Autor:
F F, Zheng, S D, Kuduk, G, Chiosis, P N, Münster, L, Sepp-Lorenzino, S J, Danishefsky, N, Rosen
Publikováno v:
Cancer research. 60(8)
Geldanamycin (GM) is a natural antibiotic that binds Hsp90 and induces the degradation of receptor tyrosine kinases, steroid receptors, and Raf. It is a potent inhibitor of cancer cells that overexpress HER-kinases, but its effects on other important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6d08f9af3f34d30ee4ee13473e60a2c
https://pubmed.ncbi.nlm.nih.gov/10786665
https://pubmed.ncbi.nlm.nih.gov/10786665
Autor:
V, Kudryashov, G, Ragupathi, I J, Kim, M E, Breimer, S J, Danishefsky, P O, Livingston, K O, Lloyd
Publikováno v:
Glycoconjugate journal. 15(3)
Globo H (Fuc alpha1 --2Galbeta1 --3GalNAcbeta1 --3Gal alpha1 --4Galbeta1 --4Glc) is a carbohydrate structure that shows enhanced expression in many human carcinomas. From mice immunized with a globo H-KLH (keyhole limpet hemocyanin) synthetic conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f54e1d6040edf6dd128a8eae1b575d0
https://pubmed.ncbi.nlm.nih.gov/9579801
https://pubmed.ncbi.nlm.nih.gov/9579801