Výsledky vyhledávání - "S J, Boulton"

MRE11 stability is regulated by CK2-dependent interaction with R2TP complex

Autor: P, von Morgen, K, Burdova, T G, Flower, N J, O'Reilly, S J, Boulton, S J, Smerdon, L, Macurek, Z, Hořejší

Publikováno v: Oncogene

The MRN (MRE11–RAD50–NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8f6e995c030e918902b543166318e33
https://pubmed.ncbi.nlm.nih.gov/28436950

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Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

Autor: S J, Boulton, S P, Jackson

Publikováno v: The EMBO journal. 15(18)

Ku, a heterodimer of polypeptides of approximately 70 kDa and 80 kDa (Ku70 and Ku80, respectively), binds avidly to DNA double-strand breaks (DSBs). Mammalian cells defective in Ku are hypersensitive to ionizing radiation due to a deficiency in DSB r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ef9ed7e24c0e6760022d4bfb41097c1
https://pubmed.ncbi.nlm.nih.gov/8890183

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