Výsledky vyhledávání - "S Ia, Mel'nik"

Autor: V M Adanin, L D Garaeva, I V Iartseva, S Ia Mel'nik, A A Bakhmedova

Publikováno v: Russian Journal of Bioorganic Chemistry. 29:160-167

1-(2,3,5-Tri-O-acetyl)-beta-D-ribofuranosyl indole, the key compound in the synthesis of glycosides with the bis(indole) aglycone, was obtained for the first time by the indoline-indole method. There were synthesized 3-(1-methylindol-3-yl)-4-(1-glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79880afce0357772f30895afc924ae1d
https://doi.org/10.1023/a:1023212532748

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[3-(1H-indol-3-yl)-4-(1-glykozylindol-3-yl)-1H-pyrrole-2,5-diones: synthesis and study of antiproliferative properties]

Autor: S Ia, Mel'nik, A A, Bakhmedova, L D, Garaeva, T D, Miniker, I L, Plikhtiak, L V, Ektova, T P, Ivanova, V M, Adanin, I V, Iartseva

Publikováno v: Bioorganicheskaia khimiia. 22(10-11)

A synthesis of 3-(1H-3-indolyl)-4-(1-glycosyl-3-indolyl)furan-2,5-diones and -1H-pyrrole-2,5-diones modified with the residues of D-ribo-, D-xylo-, L-arabino-, D-galactopyranose, and D-lactose was described. Influence of the compounds prepared on DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::decd233bf0db4f8e5a593e82659b72fb
https://pubmed.ncbi.nlm.nih.gov/9036842

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[Synthesis and antiproliferative properties of glycosides of bis(indolyl)furan-2,5-dione and bis(indolyl)-1H-pyrrol-2,5-dione]

Autor: S Ia, Mel'nik, A A, Bakhmedova, L D, Garaeva, O V, Goriunova, T D, Miniker, I L, Plikhtiak, L V, Ektova, I V, Iartseva

Publikováno v: Bioorganicheskaia khimiia. 22(6)

A synthesis of the derivatives of bis(indolyl)furan and bis(indolyl)pyrrole, which contain an acyclic fragment or a residue of D-ribo-, D-xylo-, L-arabino-, D-galactopyranose, or D-lactose was described. Bis(indole) aglycone was created using 1-glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0dbe99c3419478f7cc1e1991e95e8ca
https://pubmed.ncbi.nlm.nih.gov/8975674

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[Modulation of the antitumor activity of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoure a by O(6)-methyl-2'-deoxyguanosine--a new inhibitor of O(6)-alkylguanine-DNA-alkyltransferase]

Autor: L Iu, Dederer, I S, Sokolova, A A, Bakhmedova, T D, Miniker, S Ia, Mel'nik, L B, Gorbacheva

Publikováno v: Biokhimiia (Moscow, Russia). 60(9)

O6-Methyl-2'-deoxyguanosine (O6-MedG), a novel inhibitor of O6-alkylguanine-DNA alkyltransferase (O6-AGT), has been synthesized. The ability of O6-MedG to deplete the O6-AGT activity in leukemia L1210 and melanoma B16 cells in vivo has been studied.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cc64a75bf2bdd37729256cf23c719fb
https://pubmed.ncbi.nlm.nih.gov/8562657

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[Synthesis and biological properties of pyrimidine 2'-deoxynucleosides modified by a residue of quinaldic acid]

Autor: L V, Ektova, I V, Iartseva, E V, Khorosheva, T P, Ivanova, N P, Iavorskaia, S Ia, Mel'nik

Publikováno v: Bioorganicheskaia khimiia. 21(8)

O-Quinaldoyl derivatives of thymidine, 2'-deoxyuridine, and 5-trimethylsilyl-2'-deoxyuridine were synthesized. 5'-Deoxy-5'-(quinoline-2-carbonylamino)- and 5'-deoxy-5'-[(quinoline-2-carbonylamino)butyroylamino]thymidine were obtained by the reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69b681ef9a7c9f1015596aa84a32c1c3
https://pubmed.ncbi.nlm.nih.gov/8540903

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[Modification of pyrimidine nucleosides using nicotinic acid derivatives]

Autor: S V, Makutova, I L, Plikhtiak, I V, Iartseva, T P, Ivanova, S Ia, Mel'nik

Publikováno v: Bioorganicheskaia khimiia. 21(4)

Interaction of nicotinoyl chloride in situ with 2'-deoxyuridine, its 3'-O-acetyl-, or 5'-O-trityl derivatives led to 3'-O-nicotinoyl-, 5'-O-nicotinoyl-, 3',5'-di-O-nicotinoyl-, and N3,3'-di-O-nicotinoyl-2'-deoxyuridine. Similarly, 5'-O-nicotinoyl-6-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d1ecab00f2c1568de9dda008fa59aba
https://pubmed.ncbi.nlm.nih.gov/7786320

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[Synthesis of potential antimetabolites in a series of carbohydrate-modified pyrimidine 2'-deoxynucleosides]

Autor: A A, Bakhmedova, I V, Iartseva, S Ia, Mel'nik

Publikováno v: Bioorganicheskaia khimiia. 21(1)

The interaction of 3'-amino-2',3'-dideoxy- or 5'-amino-2',5'-dideoxy-5-substituted pyrimidine nucleosides with N-ethylmaleimide in DMF in the presence of Et3N gave two diastereomeric 2',3'-dideoxy-3'-(N-ethylsuccinimido)- or 2',5'-dideoxy-5'-(N-ethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff08b6ac07b67156fa5a8ee8b3f96e0e
https://pubmed.ncbi.nlm.nih.gov/7710424

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[Synthesis and cytotoxic properties of anomeric 5-substituted 3'-azido-2',3'-dideoxyuridines]

Autor: A A, Bakhmedova, I V, Iartseva, O S, Zhukova, T P, Volosiuk, A M, Iurkevich, S Ia, Mel'nik

Publikováno v: Bioorganicheskaia khimiia. 18(3)

Glycosylation of trimethylsilyl derivatives of 5-benzyloxymethyl- and 5-hydroxymethyluracil with 3-azido-2,3-dideoxy-5-O-benzoyl-D-ribofuranosyl chloride (prepared from ethyl 3-azido-2,3-dideoxy-5-O-benzoyl-D-ribofuranoside) and subsequent deacylatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a29e77a7620305ddf8ee1a9d672a7677
https://pubmed.ncbi.nlm.nih.gov/1524593

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[Search for antimetabolites among 5-trimethylsilyluracil nucleosides and their nonglycoside analogs]

Autor: S Ia, Mel'nik, A A, Bakhmedova, I V, Iartseva, M N, Preobrazhenskaia, O A, Zaguliaeva, V P, Mamaev

Publikováno v: Bioorganicheskaia khimiia. 17(11)

The reaction of 2'-deoxy-5-trimethylsilyl(Tms)uridine with methanesulfonyl chloride led to the corresponding 3',5'-di-O-mesyl derivative, which was treated with lithium toluylate in DMF to give 2,3'-anhydro-1-(2-deoxy-5-O-p-toluyl-beta-D-xylofurano-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a8d15e7d1460deec88c5c349ef2744d4
https://pubmed.ncbi.nlm.nih.gov/1667356

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[Synthesis, conversion and biological activity of 5-substituted 2'-deoxyuridines modified by carbohydrates]

Autor: S Ia, Mel'nik, A A, Bakhmedova, I V, Iartseva, O S, Zhukova, N P, Iavorskaia

Publikováno v: Bioorganicheskaia khimiia. 17(8)

5-Benzyloxymethyl(Bom)-2'-deoxyuridine and its alpha-anomer were used as the key compounds for syntheses of thymidine analogues or 3'-derivatives. Anomeric 5-Bom-2'-deoxyuridines were synthesized from 5-Bom-uracil and 2-deoxy-3,5-di-O-p-toluyl-alpha-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::127830a8d7424b50917f73fc839f27f7
https://pubmed.ncbi.nlm.nih.gov/1750837

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