Zobrazeno 1 - 10
of 295
pro vyhledávání: '"S Hanlon"'
Autor:
Maryna V. Ivanchenko, Killian S. Hanlon, Daniel M. Hathaway, Alex J. Klein, Cole W. Peters, Yaqiao Li, Panos I. Tamvakologos, Josette Nammour, Casey A. Maguire, David P. Corey
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 382-398 (2021)
Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even so, there are few AAV capsids that transduce both inner and outer hair cells
Externí odkaz:
https://doaj.org/article/475fe1182acd4ea6b521c663f3fd4d5c
Autor:
Naomi Chadderton, Arpad Palfi, Daniel M. Maloney, Matthew Carrigan, Laura K. Finnegan, Killian S. Hanlon, Ciara Shortall, Mary O’Reilly, Peter Humphries, Lorraine Cassidy, Paul F. Kenna, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 322 (2023)
AAV gene therapy for ocular disease has become a reality with the market authorisation of LuxturnaTM for RPE65-linked inherited retinal degenerations and many AAV gene therapies currently undergoing phase III clinical trials. Many ocular disorders ha
Externí odkaz:
https://doaj.org/article/bd632e8c331249f2b641b632703c689a
Autor:
Killian S. Hanlon, Jonah C. Meltzer, Tetyana Buzhdygan, Ming J. Cheng, Miguel Sena-Esteves, Rachel E. Bennett, Timothy P. Sullivan, Roshanak Razmpour, Yi Gong, Carrie Ng, Josette Nammour, Daniela Maiz, Simon Dujardin, Servio H. Ramirez, Eloise Hudry, Casey A. Maguire
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 320-332 (2019)
Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery vectors. We designed an AAV library construct, iTransduce, that combines a peptide library on the AAV9 capsid with a Cre cassette to enable sensitive detection o
Externí odkaz:
https://doaj.org/article/52e01ca87cb94b9eaa2bbaf0a5e3ec5e
Autor:
Killian S. Hanlon, Benjamin P. Kleinstiver, Sara P. Garcia, Mikołaj P. Zaborowski, Adrienn Volak, Stefan E. Spirig, Alissa Muller, Alexander A. Sousa, Shengdar Q. Tsai, Niclas E. Bengtsson, Camilla Lööv, Martin Ingelsson, Jeffrey S. Chamberlain, David P. Corey, Martin J. Aryee, J. Keith Joung, Xandra O. Breakefield, Casey A. Maguire, Bence György
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In-depth characterization of adeno-associated virus (AAV)-mediated CRISPR delivery is still lacking. Here, the authors show high levels of integration into Cas9-induced double-strand breaks (DSBs) in therapeutically relevant genes in vivo.
Externí odkaz:
https://doaj.org/article/d463e02a3bdc40c4aca343f4b409877a
Autor:
Bence György, Elise J. Meijer, Maryna V. Ivanchenko, Kelly Tenneson, Frederick Emond, Killian S. Hanlon, Artur A. Indzhykulian, Adrienn Volak, K. Domenica Karavitaki, Panos I. Tamvakologos, Mark Vezina, Vladimir K. Berezovskii, Richard T. Born, Maureen O’Brien, Jean-François Lafond, Yvan Arsenijevic, Margaret A. Kenna, Casey A. Maguire, David P. Corey
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 1-13 (2019)
Hereditary hearing loss often results from mutation of genes expressed by cochlear hair cells. Gene addition using AAV vectors has shown some efficacy in mouse models, but clinical application requires two additional advances. First, new AAV capsids
Externí odkaz:
https://doaj.org/article/6758ea888ad8422f9ec07444e4da3682
Autor:
Thomas S. van Solinge, Erik R. Abels, Lieke L. van de Haar, Killian S. Hanlon, Sybren L. N. Maas, Rosalie Schnoor, Jeroen de Vrij, Xandra O. Breakefield, Marike L. D. Broekman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Introduction: Glioma cells exert influence over the tumor-microenvironment in part through the release of extracellular vesicles (EVs), membrane-enclosed structures containing proteins, lipids, and RNAs. In this study, we evaluated the function of Ra
Externí odkaz:
https://doaj.org/article/b0557c179e79404c881d03d2332a9977
Akademický článek
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Publikováno v:
Trends Pharmacol Sci
As gene therapy enters mainstream medicine, it is more important than ever to have a grasp of exactly how to leverage it for maximum benefit. The development of new targeting strategies and tools makes treating patients with genetic diseases possible
Autor:
Killian S. Hanlon, Naomi Chadderton, Arpad Palfi, Alfonso Blanco Fernandez, Peter Humphries, Paul F. Kenna, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Significant advances in gene therapy have enabled exploration of therapies for inherited retinal disorders, many of which are in preclinical development or clinical evaluation. Gene therapy for retinal conditions has led the way in this growing field
Externí odkaz:
https://doaj.org/article/04cb834d403e47d8ba622955f1dd673d
Autor:
Killian S. Hanlon, Casey A. Maguire, Daniel M. Hathaway, David P. Corey, Alex J. Klein, Josette Nammour, Panos I. Tamvakologos, Yaqiao Li, Maryna V. Ivanchenko, Cole Peters
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 382-398 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 382-398 (2021)
Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even so, there are few AAV capsids that transduce both inner and outer hair cells