Zobrazeno 1 - 10
of 43
pro vyhledávání: '"S H Yalkowsky"'
Publikováno v:
Journal of Lipid Research, Vol 25, Iss 2, Pp 189-197 (1984)
The fat solubilities of some long chain fatty acids, alcohols, alkanes, and triacyglycerols, and of some aromatic, chlorinated aromatic, and chlorinated aliphatic hydrocarbons were measured in trioleoylglycerol. Above their melting temperature, all t
Externí odkaz:
https://doaj.org/article/5111ab3e621c49bea541b6fb997ab15e
Publikováno v:
Pharmaceutical research. 18(12)
Autor:
N, Jain, S H, Yalkowsky
Publikováno v:
Journal of pharmaceutical sciences. 90(2)
The estimation of aqueous solubilities of organic nonelectrolytes by the General Solubility Equation (GSE) as proposed by Valvani and Yalkowsky (1980) is used in this study. The data and assumptions on which the GSE are based are reevaluated, and the
Publikováno v:
PDA journal of pharmaceutical science and technology. 53(3)
Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the
Publikováno v:
Journal of pharmaceutical sciences. 89(12)
The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partitio
Publikováno v:
PDA journal of pharmaceutical science and technology. 52(4)
Autor:
J F, Krzyzaniak, S H, Yalkowsky
Publikováno v:
PDA journal of pharmaceutical science and technology. 52(2)
The percent hemolysis induced by various surfactants was determined as a function of the formulation composition and formulation: blood contact time using the dynamic in vitro method of Krzyzaniak et al. (1). The amount of hemolysis induced by nonion
Autor:
F A, Alvarez Núñez, S H, Yalkowsky
Publikováno v:
PDA journal of pharmaceutical science and technology. 52(1)
Several attempts to increase diazepam solubility are in the literature. This study discusses these different solubilization approaches. Specific reference is given to the rationale in the application of pH control, cosolvency, surfactants, and cyclod
Publikováno v:
PDA journal of pharmaceutical science and technology. 50(6)
Flavopiridol [5,7-dihydroxy-8-(4-N-methyl-2-hydroxypyridyl)-6' -chloroflavone hydrochloride] is a flavonoid with weak electrolyte properties and an intrinsic aqueous solubility of 0.024 mg/mL. Neither cosolvency complexation, nor pH control alone can
Publikováno v:
PDA journal of pharmaceutical science and technology. 50(4)
A dynamic in vitro method for the determination of the degree of hemolysis induced by parenteral formulations is presented. This method utilizes a dual syringe pump apparatus that enables the mixing of a formulation with blood in various ratios and f