Zobrazeno 1 - 10
of 74
pro vyhledávání: '"S H, Orkin"'
Autor:
Francesca Persichetti, Christine M. Ambrose, Pei Ge, Sandra M. McNeil, Jayalakshmi Srinidhi, Mary Anne Anderson, Barbara Jenkins, Glenn T. Barnes, Mabel P. Duyao, Lisa Kanaley, Nancy S. Wexler, Richard H. Myers, Edward D. Bird, Jean-Paul Vonsattel, Marcy E. MacDonald, James F. Gusella, S. H. Orkin
Publikováno v:
Molecular Medicine. 1:374-383
An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington’s disease (HD), but its mode of action has yet to be discovered. The sequence of the HD gene places the CAG repeat near the 5′ end in a region wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09f642c310a48b9c94ccb9109b361257
https://doi.org/10.1007/bf03401575
https://doi.org/10.1007/bf03401575
Autor:
D M, Bodine, T, Moritz, R E, Donahue, B D, Luskey, S W, Kessler, D I, Martin, S H, Orkin, A W, Nienhuis, D A, Williams
Publikováno v:
Blood. 82:1975-1980
Retroviral mediated gene transfer into stem cells has been proposed as therapy for many inherited hematopoietic diseases. Deficiency of the enzyme adenosine deaminase (ADA) results in depletion of T lymphocytes, causing severe combined immunodeficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5a1f4074561461b3628f99756a442f
https://doi.org/10.1182/blood.v82.7.1975.1975
https://doi.org/10.1182/blood.v82.7.1975.1975
Publikováno v:
Molecular and Cellular Biology. 13:3999-4010
GATA-binding proteins constitute a family of transcription factors that recognize a target site conforming to the consensus WGATAR (W = A or T and R = A or G). Here we have used the method of polymerase chain reaction-mediated random site selection t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b763571e85b10d3ce0fd47a80ae77cd1
https://doi.org/10.1128/mcb.13.7.3999
https://doi.org/10.1128/mcb.13.7.3999
Autor:
L I, Zon, Y, Yamaguchi, K, Yee, E A, Albee, A, Kimura, J C, Bennett, S H, Orkin, S J, Ackerman
Publikováno v:
Blood. 81:3234-3241
The expression of the hematopoietic transcription factors GATA-1, GATA- 2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96214ff663bc8fe5f74764cef8ebef00
https://doi.org/10.1182/blood.v81.12.3234.bloodjournal81123234
https://doi.org/10.1182/blood.v81.12.3234.bloodjournal81123234
Autor:
M, de Boer, B G, Bolscher, M C, Dinauer, S H, Orkin, C I, Smith, A, Ahlin, R S, Weening, D, Roos
Publikováno v:
Blood. 80:1553-1558
Chronic granulomatous disease (CGD) is characterized by the absence of a respiratory burst in activated phagocytes. Defects in at least four different genes lead to CGD. Patients with the X-linked form of CGD have mutations in the gene for the beta-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9631a221ae3a6fbe7f477a16c3778929
https://doi.org/10.1182/blood.v80.6.1553.bloodjournal8061553
https://doi.org/10.1182/blood.v80.6.1553.bloodjournal8061553
Publikováno v:
Molecular and Cellular Biology. 12:2135-2142
A major regulatory element required for expression of the human alpha-globin genes is located 40 kb upstream of the embryonic zeta-globin gene. To understand how this and other locus control region (LCR) elements contribute to high-level expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9b1eb6c92eb441f09e77c93aa815f3
https://doi.org/10.1128/mcb.12.5.2135-2142.1992
https://doi.org/10.1128/mcb.12.5.2135-2142.1992
Publikováno v:
Blood. 76:2443-2448
Phagocytes from X-linked chronic granulomatous disease (X-CGD) patients are deficient in their ability to generate superoxide because of a defective gene that encodes a heavy chain of cytochrome b, a critical component in the superoxide-generating pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20466319b685e597b3fc6fdce0008de7
https://doi.org/10.1182/blood.v76.12.2443.bloodjournal76122443
https://doi.org/10.1182/blood.v76.12.2443.bloodjournal76122443
Publikováno v:
Molecular and Cellular Biology. 10:6596-6606
Erythropoiesis in vertebrates is characterized by sequential changes in erythropoietic site, erythroblast morphology, and hemoglobin synthesis. We have examined the expression of globin chains and the major erythroid transcription factor GATA-1 (prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de38ab25214387caa060a5baa11bb51
https://doi.org/10.1128/mcb.10.12.6596
https://doi.org/10.1128/mcb.10.12.6596
Publikováno v:
Molecular and Cellular Biology. 10:6051-6054
Two platelet-derived growth factor A-chain proteins, termed short and long A chains, are generated as a result of alternative mRNA splicing of exon 6 of the A-chain gene. S1 nuclease mapping and polymerase chain reaction analyses demonstrate that bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3168d287180946dfc1b18e705e5ed93
https://doi.org/10.1128/mcb.10.11.6051-6054.1990
https://doi.org/10.1128/mcb.10.11.6051-6054.1990
Publikováno v:
Molecular and Cellular Biology. 10:4854-4862
Endothelin-1 (ET-1) is a 21-amino-acid peptide synthesized by endothelial cells that has potent vasoconstrictor activity. Human ET-1 is derived from a 212-amino-acid prepropeptide, termed preproendothelin-1 (PPET-1). To identify cis-acting sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::536980aafa422746bfcd8aa250aac36e
https://doi.org/10.1128/mcb.10.9.4854
https://doi.org/10.1128/mcb.10.9.4854