Výsledky vyhledávání - "S H, Kadwell"

Cyclic AMP signaling pathways are important in IL-1 beta transcriptional regulation

Autor: G Chandra, J P Cogswell, L R Miller, M M Godlevski, S W Stinnett, S L Noel, S H Kadwell, T A Kost, J G Gray

Publikováno v: The Journal of Immunology. 155:4535-4543

An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha. In the present study, usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7edbe2367764fd5ef761ed52b936b9f
https://doi.org/10.4049/jimmunol.155.10.4535

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Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat

Autor: J D, Stuart, F W, Lee, D, Simpson Noel, S H, Kadwell, L K, Overton, C R, Hoffman, T A, Kost, T K, Tippin, R L, Yeager, K W, Batchelor, H N, Bramson

Publikováno v: Biochemical pharmacology. 62(7)

The interaction of baculovirus expressed rat steroid 5alpha-reductase types 1 and 2 (r5AR1 and r5AR2) with 17beta-N-(2,5-bis(trifluoromethyl)phenyl)carbamoyl-4-aza-5alpha-androst-1-en-3-one (GI198745) was investigated at pH 7 and 37 degrees. This 5al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74b67dc463dbf35e4e8f4311611baf45
https://pubmed.ncbi.nlm.nih.gov/11543729

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Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail

Autor: L M, Shewchuk, A M, Hassell, B, Ellis, W D, Holmes, R, Davis, E L, Horne, S H, Kadwell, D D, McKee, J T, Moore

Publikováno v: Structure (London, England : 1993). 8(11)

Angiogenesis, the formation of new vessels from the existing vasculature, is a critical process during early development as well as in a number of disease processes. Tie2 (also known as Tek) is an endothelium-specific receptor tyrosine kinase involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::789fc9b545a493e18c06c94349c4bff9
https://pubmed.ncbi.nlm.nih.gov/11080633

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Inhibition of human steroid 5alpha reductases type I and II by 6-aza-steroids: structural determinants of one-step vs two-step mechanism

Autor: M L, Moss, P, Kuzmic, J D, Stuart, G, Tian, A G, Peranteau, S V, Frye, S H, Kadwell, T A, Kost, L K, Overton, I R, Patel

Publikováno v: Biochemistry. 35(11)

We have discovered that 17beta-[N,N-(diethyl)carbamoyl]-6-azaandrost-4-en-3-one is a time-dependent inhibitor of type II 5alpha-reductase, as is the drug finasteride. Unlike finasteride, the 6-aza-steroid is not a time-dependent inhibitor of type I 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73b1f638df7a6de1206a267264c13d20
https://pubmed.ncbi.nlm.nih.gov/8639496

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Akademický článek

Solvent‐Free Synthesis and In Vitro Antitumor Activity of a New Class of (Z)‐3‐Arylidene‐1H‐pyrano[3,4‐b]quinolin‐4(3H)‐ones.

Autor: Li, Yang¹ (AUTHOR), Tang, Bingyue¹ (AUTHOR), Dong, Shiyu¹ (AUTHOR), Gao, Wentao¹ (AUTHOR) isfcli@bhu.edu.cn, Jiang, Wenting² (AUTHOR), Chen, Yu³ (AUTHOR) 569180398@qq.com

Publikováno v: ChemistrySelect. 3/6/2020, Vol. 5 Issue 9, p2746-2752. 7p.

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