Výsledky vyhledávání

Does apolipoprotein E genotype modify the clinical expression of ALS?

Autor: A, Jawaid, M, Poon, A M, Strutt, L K, Rice, E J, McDowell, A R, Salamone, S U, Qureshi, E, Simpson, S H, Appel, M K, York, P E, Schulz

Publikováno v: European journal of neurology. 18(4)

The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e97ce45cad36189b680ab45f62a91d0e
https://pubmed.ncbi.nlm.nih.gov/20880000

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ALS disease onset may occur later in patients with pre-morbid diabetes mellitus

Autor: A, Jawaid, A R, Salamone, A M, Strutt, S B, Murthy, M, Wheaton, E J, McDowell, E, Simpson, S H, Appel, M K, York, P E, Schulz

Publikováno v: European journal of neurology. 17(5)

Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a85a27ca60d503a1727a02eb7490d38f
https://pubmed.ncbi.nlm.nih.gov/20074230

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Immunosuppression and anti-inflammatory agents in ALS

Autor: R G, Smith, S H, Appel

Publikováno v: Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6394d3a19062576583129612141f5ed8
https://pubmed.ncbi.nlm.nih.gov/11466958

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Altered calcium homeostasis in ALS as a target for therapy

Autor: S H, Appel, D, Beers, R G, Smith, J E, Wilson

Publikováno v: Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26248b7ccabb2187547ec9c00a48bdb5
https://pubmed.ncbi.nlm.nih.gov/11466956

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Calcium: the Darth Vader of ALS

Autor: S H, Appel, D, Beers, L, Siklos, J I, Engelhardt, D R, Mosier

Publikováno v: Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. 2

Motor neuron dysfunction and loss in amyotrophic lateral sclerosis (ALS) have been attributed to several different mechanisms, including increased intracellular calcium, glutamate excitotoxicity, oxidative stress and free radical damage, mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97734da2ed1f88344f3c0677d015a569
https://pubmed.ncbi.nlm.nih.gov/11465925

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Ultrastructural evidence of calcium involvement in experimental autoimmune gray matter disease

Autor: M E, Alexianu, E, Manole, J I, Engelhardt, S H, Appel

Publikováno v: Journal of neuroscience research. 60(1)

Experimental studies have suggested that increased calcium and inappropriate calcium handling by motoneurons might have a significant role in motoneuron degeneration. To further define the involvement of calcium in motoneuron loss we used the oxalate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2f5c6ac2ede796a9f92439a7965ee3a
https://pubmed.ncbi.nlm.nih.gov/10723072

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Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury

Autor: W, Le, O M, Conneely, Y, He, J, Jankovic, S H, Appel

Publikováno v: Journal of neurochemistry. 73(5)

Mutation in the Nurr1 gene, a member of the nuclear receptor superfamily, causes selective agenesis of dopaminergic neurons in the midbrain of null mice. Homozygous Nurr1 knockout mice (Nurr1-/-) die 1 day after birth, but heterozygous mice (Nurr1 +/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7723470ae66656a62e886d77a2c8cfd3
https://pubmed.ncbi.nlm.nih.gov/10537083

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Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury

Autor: W D, Le, W J, Xie, S H, Appel

Publikováno v: Journal of neuroscience research. 56(6)

Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with beta-amyloid peptide (beta-AP1-40) or hydrogen peroxide (H2O2), we detected high levels of rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f9473a759f3e23ccfd952fb1021b115
https://pubmed.ncbi.nlm.nih.gov/10374820

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Antibodies from patients with Parkinson's disease react with protein modified by dopamine oxidation

Autor: D B, Rowe, W, Le, R G, Smith, S H, Appel

Publikováno v: Journal of neuroscience research. 53(5)

To determine whether specific antibodies are present in PD, we used an enzyme-linked immunosorbant assay (ELISA) that identifies increased immunoglobulin (IgG) levels towards a synthetic substrate prepared by incubating ovalbumin with dopamine and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::838aa5d9a2b468377e0d76cecbf6553d
https://pubmed.ncbi.nlm.nih.gov/9726426

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