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pro vyhledávání: '"S Grissmer"'
Akademický článek
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Publikováno v:
The Journal of Membrane Biology. 178:11-20
The calcium indicator fura-2 was used to study the effect of hypotonic solutions on the intracellular calcium concentration, [Ca(2+)](i), in a human osteoblast-like cell line. Decreasing the tonicity of the extracellular solution to 50% leads to an i
Autor:
S I, Schmid, S, Grissmer
Publikováno v:
British journal of pharmacology. 163(3)
Voltage-gated K(v)1.3 channels appear on T-lymphocytes and are characterized by their typical C-type inactivation. In order to develop drugs stabilizing the C-type inactivated state and thus potentially useful in treatment of autoimmune diseases, it
CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels
Publikováno v:
The Journal of Immunology. 145:2105-2109
Expression of voltage-gated K+ channels in mAb-defined T cell subsets from normal mice and mice with experimental autoimmune arthritis was studied with the patch-clamp whole-cell recording technique in combination with fluorescence microscopy. CD4+CD
Akademický článek
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Autor:
R J, Röbe, S, Grissmer
Publikováno v:
British journal of pharmacology. 131(7)
1. Phenylalkylamines (PAA) usually known for their action on L-type Ca(2+) channels potently block the C-type inactivating lymphocyte Kv1.3 channel resulting in inhibition of activation of T lymphocytes. In order to design PAAs blocking Kv1.3 specifi
Autor:
D C, Hanson, A, Nguyen, R J, Mather, H, Rauer, K, Koch, L E, Burgess, J P, Rizzi, C B, Donovan, M J, Bruns, P C, Canniff, A C, Cunningham, K A, Verdries, E, Mena, J C, Kath, G A, Gutman, M D, Cahalan, S, Grissmer, K G, Chandy
Publikováno v:
British journal of pharmacology. 126(8)
1. UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, Kv1.3, was discovered by screening a large compound file using a high-throughput 86Rb efflux assay. This compound blocks Kv1.3 with a IC50 of approximately 200 nM
Autor:
A, Nguyen, J C, Kath, D C, Hanson, M S, Biggers, P C, Canniff, C B, Donovan, R J, Mather, M J, Bruns, H, Rauer, J, Aiyar, A, Lepple-Wienhues, G A, Gutman, S, Grissmer, M D, Cahalan, K G, Chandy
Publikováno v:
Molecular pharmacology. 50(6)
The nonpeptide agent CP-339,818 (1-benzyl-4-pentylimino-1,4-dihydroquinoline) and two analogs (CP-393,223 and CP-394,322) that differ only with respect to the type of substituent at the N1 position, potently blocked the Kv1.3 channel in T lymphocytes
Autor:
H, Rauer, S, Grissmer
Publikováno v:
Molecular pharmacology. 50(6)
We characterized the action of verapamil and N-methyl-verapamil on current through the delayed-rectifier potassium channel Kv1.3 mouse (mKv1.3). The whole-cell and inside-out configuration of the patch-clamp technique was used to examine the channel
Autor:
S, Grissmer, A N, Nguyen, J, Aiyar, D C, Hanson, R J, Mather, G A, Gutman, M J, Karmilowicz, D D, Auperin, K G, Chandy
Publikováno v:
Molecular pharmacology. 45(6)
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines. Kv1.1 is biophysically similar to a K+ channel in C6 glioma cells and as