Zobrazeno 1 - 10
of 316
pro vyhledávání: '"S Gnanakaran"'
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1005972 (2018)
Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a broad spectrum of biological effects within the host organism, stemming from its interactio
Externí odkaz:
https://doaj.org/article/9343a1d15f8e4a7a897ba8afa8e2e86f
Autor:
Jianhui Tian, Cesar A López, Cynthia A Derdeyn, Morris S Jones, Abraham Pinter, Bette Korber, S Gnanakaran
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 10, p e1005094 (2016)
Heavy glycosylation of the envelope (Env) surface subunit, gp120, is a key adaptation of HIV-1; however, the precise effects of glycosylation on the folding, conformation and dynamics of this protein are poorly understood. Here we explore the pattern
Externí odkaz:
https://doaj.org/article/7b10fe7e17ec408a905549985723221a
Autor:
Pedro D. Manrique, Inga V. Leus, César A. López, Jitender Mehla, Giuliano Malloci, Silvia Gervasoni, Attilio V. Vargiu, Rama K. Kinthada, Liam Herndon, Nicolas W. Hengartner, John K. Walker, Valentin V. Rybenkov, Paolo Ruggerone, Helen I. Zgurskaya, S. Gnanakaran
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The ability Gram-negative pathogens have at adapting and protecting themselves against antibiotics has increasingly become a public health threat. Data-driven models identifying molecular properties that correlate with outer membrane (OM) pe
Externí odkaz:
https://doaj.org/article/45d6aee426a544c597e58b71c5e0adb4
Autor:
Megan K Murphy, Ling Yue, Ruimin Pan, Saikat Boliar, Anurag Sethi, Jianhui Tian, Katja Pfafferot, Etienne Karita, Susan A Allen, Emmanuel Cormier, Paul A Goepfert, Persephone Borrow, James E Robinson, S Gnanakaran, Eric Hunter, Xiang-Peng Kong, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003173 (2013)
Antibodies that neutralize (nAbs) genetically diverse HIV-1 strains have been recovered from a subset of HIV-1 infected subjects during chronic infection. Exact mechanisms that expand the otherwise narrow neutralization capacity observed during early
Externí odkaz:
https://doaj.org/article/1edc3710ec2d4edda9d5d3b09d3a1741
Autor:
Raphael Gottardo, Robert T Bailer, Bette T Korber, S Gnanakaran, Joshua Phillips, Xiaoying Shen, Georgia D Tomaras, Ellen Turk, Gregory Imholte, Larry Eckler, Holger Wenschuh, Johannes Zerweck, Kelli Greene, Hongmei Gao, Phillip W Berman, Donald Francis, Faruk Sinangil, Carter Lee, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Merlin L Robb, Nelson L Michael, Jerome H Kim, Susan Zolla-Pazner, Barton F Haynes, John R Mascola, Steve Self, Peter Gilbert, David C Montefiori
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75665 (2013)
Neutralizing and non-neutralizing antibodies to linear epitopes on HIV-1 envelope glycoproteins have potential to mediate antiviral effector functions that could be beneficial to vaccine-induced protection. Here, plasma IgG responses were assessed in
Externí odkaz:
https://doaj.org/article/df8c4ccdd54e4bd9aaaede24511613f5
A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein.
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003046 (2013)
The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion
Externí odkaz:
https://doaj.org/article/880186ee833746e08d387f48f4f57d7b
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002192 (2011)
Numerous signaling proteins use multivalent binding to increase the specificity and affinity of their interactions within the cell. Enhancement arises because the effective binding constant for multivalent binding is larger than the binding constants
Externí odkaz:
https://doaj.org/article/86c8f71267a44f54a1e1c8e163c470fd
Autor:
S Gnanakaran, Tanmoy Bhattacharya, Marcus Daniels, Brandon F Keele, Peter T Hraber, Alan S Lapedes, Tongye Shen, Brian Gaschen, Mohan Krishnamoorthy, Hui Li, Julie M Decker, Jesus F Salazar-Gonzalez, Shuyi Wang, Chunlai Jiang, Feng Gao, Ronald Swanstrom, Jeffrey A Anderson, Li-Hua Ping, Myron S Cohen, Martin Markowitz, Paul A Goepfert, Michael S Saag, Joseph J Eron, Charles B Hicks, William A Blattner, Georgia D Tomaras, Mohammed Asmal, Norman L Letvin, Peter B Gilbert, Allan C Decamp, Craig A Magaret, William R Schief, Yih-En Andrew Ban, Ming Zhang, Kelly A Soderberg, Joseph G Sodroski, Barton F Haynes, George M Shaw, Beatrice H Hahn, Bette Korber
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002209 (2011)
Here we have identified HIV-1 B clade Envelope (Env) amino acid signatures from early in infection that may be favored at transmission, as well as patterns of recurrent mutation in chronic infection that may reflect common pathways of immune evasion.
Externí odkaz:
https://doaj.org/article/22d53c62f6de46ae98a1717e386d0e84
Autor:
Mohammed Asmal, Ina Hellmann, Weimin Liu, Brandon F Keele, Alan S Perelson, Tanmoy Bhattacharya, S Gnanakaran, Marcus Daniels, Barton F Haynes, Bette T Korber, Beatrice H Hahn, George M Shaw, Norman L Letvin
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23673 (2011)
Mucosal transmission of the human immunodeficiency virus (HIV) results in a bottleneck in viral genetic diversity. Gnanakaran and colleagues used a computational strategy to identify signature amino acids at particular positions in Envelope that were
Externí odkaz:
https://doaj.org/article/fd8dcedb49ad4da585d28f0c6e8aa261
Autor:
S Gnanakaran, Marcus G Daniels, Tanmoy Bhattacharya, Alan S Lapedes, Anurag Sethi, Ming Li, Haili Tang, Kelli Greene, Hongmei Gao, Barton F Haynes, Myron S Cohen, George M Shaw, Michael S Seaman, Amit Kumar, Feng Gao, David C Montefiori, Bette Korber
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 10, p e1000955 (2010)
A steady increase in knowledge of the molecular and antigenic structure of the gp120 and gp41 HIV-1 envelope glycoproteins (Env) is yielding important new insights for vaccine design, but it has been difficult to translate this information to an immu
Externí odkaz:
https://doaj.org/article/a90bdc6d52af4b7da8a130c763e2816c