Zobrazeno 1 - 10
of 490
pro vyhledávání: '"S Glickman"'
Autor:
Xiansha Xiao, Allison Fay, Pablo Santos Molina, Amanda Kovach, Michael S. Glickman, Huilin Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The molecular chaperone DnaK is essential for viability of Mycobacterium tuberculosis (Mtb). DnaK hydrolyzes ATP to fold substrates, and the resulting ADP is exchanged for ATP by the nucleotide exchange factor GrpE. It has been unclear how G
Externí odkaz:
https://doaj.org/article/e7c37212224c4be3917a29c7faaee85f
Autor:
Samantha J. Nelson, John T. Williams, John A. Buglino, Subhalaxmi Nambi, Lisa J. Lojek, Michael S. Glickman, Thomas R. Ioerger, Christopher M. Sassetti
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Mycobacterium tuberculosis is exposed to a variety of stresses during a chronic infection, as the immune system simultaneously produces bactericidal compounds and starves the pathogen of essential nutrients. The intramembrane protease, Rip1,
Externí odkaz:
https://doaj.org/article/3ff0ef3e4c504a0da4ca3f3ee42264fd
Autor:
Pierre Dupuy, Shreya Ghosh, Oyindamola Adefisayo, John Buglino, Stewart Shuman, Michael S. Glickman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
This manuscript elucidates new mechanisms of mutagenesis in mycobacteria by implicating two translesion DNA polymerases in genome diversification, including creating the mutations that underlie all antibiotic resistance in these global pathogens.
Externí odkaz:
https://doaj.org/article/9c0a551c221a46cc825ba63f2991ce99
Autor:
Pierre Dupuy, Shreya Ghosh, Allison Fay, Oyindamola Adefisayo, Richa Gupta, Stewart Shuman, Michael S Glickman
Publikováno v:
eLife, Vol 12 (2023)
Translesion synthesis by translesion polymerases is a conserved mechanism of DNA damage tolerance. In bacteria, DinB enzymes are the widely distributed promutagenic translesion polymerases. The role of DinBs in mycobacterial mutagenesis was unclear u
Externí odkaz:
https://doaj.org/article/c2c0832e66b8447da45db3fdd466c1f8
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Bacterial pathogens and their hosts engage in intense competition for critical nutrients during infection, including metals such as iron, copper, and zinc. Some metals are limited by the host, and some are deployed by the host as antimicrobi
Externí odkaz:
https://doaj.org/article/95516269ca08459390eb30900637ebd9
Autor:
Matthew F. Wipperman, Shakti K. Bhattarai, Charles Kyriakos Vorkas, Venkata Suhas Maringati, Ying Taur, Laurent Mathurin, Katherine McAulay, Stalz Charles Vilbrun, Daphie Francois, James Bean, Kathleen F. Walsh, Carl Nathan, Daniel W. Fitzgerald, Michael S. Glickman, Vanni Bucci
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Antibiotic therapy can lead to pathogen clearance, but also to alterations in the gut microbiota and systemic immune responses. Here, the authors analyze data from patients with tuberculosis and healthy subjects to show that pathogen clearance and gu
Externí odkaz:
https://doaj.org/article/d1412789c68649e5804527b92e439bff
Publikováno v:
eLife, Vol 10 (2021)
Bacterial pathogens that infect phagocytic cells must deploy mechanisms that sense and neutralize host microbicidal effectors. For Mycobacterium tuberculosis, the causative agent of tuberculosis, these mechanisms allow the bacterium to rapidly adapt
Externí odkaz:
https://doaj.org/article/1a5a03298a9343d98fb0356fb5bd5737
Autor:
Allison Fay, John Philip, Priya Saha, Ronald C. Hendrickson, Michael S. Glickman, Kristin Burns-Huang
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
AMR is a global problem, especially for TB. Here, we show that mycobacterial chaperones support AMR in M. smegmatisM. tuberculosis
Externí odkaz:
https://doaj.org/article/27681e2627f94309a462f6a3b41f7ee9
Autor:
James Peek, Mirjana Lilic, Daniel Montiel, Aleksandr Milshteyn, Ian Woodworth, John B. Biggins, Melinda A. Ternei, Paula Y. Calle, Michael Danziger, Thulasi Warrier, Kohta Saito, Nathaniel Braffman, Allison Fay, Michael S. Glickman, Seth A. Darst, Elizabeth A. Campbell, Sean F. Brady
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant
Externí odkaz:
https://doaj.org/article/9a2754d11dc34b7e92b8fd4db1a27cbf
Autor:
Sri Nitya Reddy Induri, Yunah Caroline Chun, Joonmo Christopher Chun, Kenneth E. Fleisher, Robert S. Glickman, Fangxi Xu, Efthimia Ioannidou, Xin Li, Deepak Saxena
Publikováno v:
Healthcare, Vol 9, Iss 6, p 679 (2021)
The onset of the Coronavirus 2019 (COVID-19) pandemic has challenged the worldwide healthcare sector, including dentistry. The highly infectious nature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and risk of transmission thr
Externí odkaz:
https://doaj.org/article/f4f3fbd034cd489c97292d1567c28189