Zobrazeno 1 - 10
of 286
pro vyhledávání: '"S Gerondakis"'
Autor:
Dean M Talia, Devy Deliyanti, Alex Agrotis, Tong Zhu, Emily M Hargreaves, S Gerondakis, Jack R Jerome, Jennifer L. Wilkinson-Berka, Mhairi J Maxwell, Fabienne Mackay, Margaret L. Hibbs
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Neovascular retinopathies are major causes of vision loss; yet treatments to prevent the condition are inadequate. The role of regulatory T cells in neovascular retinopathy is unknown. Here we show that in retinopathy regulatory T cells are transient
Publikováno v:
Transcription. 3:245-249
In the thymus, sequential antigen and cytokine receptor signals direct the stepwise differentiation of multi-potential CD4+CD8+ thymic precursors into Foxp3+ CD4 regulatory T cells (Tregs). In this Point of View article we discuss our recent findings
Autor:
Ashish Banerjee, Ajithkumar Vasanthakumar, Raffi Gugasyan, Tom Sidwell, George Grigoriadis, S Gerondakis, Raelene J. Grumont
Publikováno v:
Immunological Reviews. 246:272-285
Summary: Although the diverse functions served by the nuclear factor-κB (NF-κB) pathway in virtually all cell types are typically employed to deal with stress responses, NF-κB transcription factors also play key roles in the development of hemopoi
Autor:
Andreas Strasser, Raelene J. Grumont, Christine L. White, S Gerondakis, Raffi Gugasyan, Ashish Banerjee
Publikováno v:
Blood. 112:5063-5073
The nuclear factor-κB (NF-κB) pathway is crucial for the survival of B cells stimulated through Toll-like receptors (TLRs). Here, we show that the heightened death of TLR4-activated nfkb1−/− B cells is the result of a failure of the Tpl2/MEK/ER
Autor:
Andreas Strasser, Ann Lin, S Gerondakis, Peter Hughes, Reema Jain, K Yaprianto, Daniel H.D. Gray, Lorraine A. O'Reilly, Jun T. Low, U Siebenlist
Publikováno v:
Immunology and cell biology. 94(1)
Defects in apoptosis can cause autoimmune disease. Loss-of-function mutations in the 'death receptor' FAS impair the deletion of autoreactive lymphocytes in the periphery, leading to progressive lymphadenopathy and systemic lupus erythematosus-like a
Autor:
Mark A. Febbraio, S Gerondakis, Raelene J. Grumont, Katherine G. Langley, Emma Estevez, Helene L. Kammoun, Graeme I. Lancaster, Ashish Banerjee, Michael J Kraakman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e111524 (2014)
PLoS ONE, Vol 9, Iss 11, p e111524 (2014)
Alterations in the immune cell profile and the induction of inflammation within adipose tissue are a hallmark of obesity in mice and humans. Dual-specificity phosphatase 2 (DUSP2) is widely expressed within the immune system and plays a key role prom
Autor:
Anne K. Voss, S Gerondakis, George Varigos, Pritinder Kaur, Raffi Gugasyan, George Grigoriadis, Raelene J. Grumont, Tim Thomas
Publikováno v:
Molecular and Cellular Biology. 24:5733-5745
Determining the roles of Rel/NF-kappaB transcription factors in mouse skin development with loss-of-function mutants has been limited by redundancy among these proteins and by embryonic lethality associated with the absence of RelA. Using mice lackin
Autor:
S Gerondakis, Mark J. Daly, Wendy D. Cook, Alan W. Harris, Jane Fridlyand, R. C. Andrew Symons, Terence P. Speed, Simon J. Foote
Publikováno v:
Proceedings of the National Academy of Sciences. 99:11299-11304
There is a great difference in susceptibility to v-abltransgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 trans
Autor:
Die Wang, Aaron T. Irving, Liang Yu, Bryan R.G. Williams, Jun-Ping Liu, Soroush Sarvestani, Dakang Xu, Ashley Mansell, Xiangliang Yuan, Ashish Banerjee, Anthony J. Sadler, S Gerondakis, Bandar A. Suliman
Publikováno v:
Nature communications. 6
To date, the activities of protein kinases have formed the core of our understanding of cell signal transduction. Comprehension of the extent of protein acetylation has raised expectations that this alternate post-transcriptional modification will be
Autor:
Daniel H.D. Gray, S Gerondakis, Andreas Strasser, Rajan Jain, Paul Waring, Lorraine A. O'Reilly, Ann Lin, Ulrich Siebenlist, Peter Hughes
Publikováno v:
Cell death and differentiation. 22(5)
FASL/FAS signaling imposes a critical barrier against autoimmune disease and lymphadenopathy. Mutant mice unable to produce membrane-bound FASL (FasL(Δm/Δm)), a prerequisite for FAS-induced apoptosis, develop lymphadenopathy and systemic autoimmune