Výsledky vyhledávání - "S G, Younkin"

Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

Autor: A M, Fagan, L H, Younkin, J C, Morris, J D, Fryer, T G, Cole, S G, Younkin, D M, Holtzman

Publikováno v: Annals of neurology. 48(2)

The epsilon4 allele of apolipoprotein E (ApoE) is a risk factor for Alzheimer's disease (AD). ApoE, which is important for lipid metabolism, is also a major constituent of cerebrospinal fluid (CSF) lipoproteins (LPs). Although ApoE in the CSF is deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c26eb68e20e4c63c5196b92fc1a31a70
https://pubmed.ncbi.nlm.nih.gov/10939571

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Metabolism and Function of Presenilin 1

Autor: S. G. Younkin, N. A. Jenkins, J. Regard, C. Eckman, N. G. Copeland, L. H. T. Van Der Ploeg, Christie L. Harris, Hilda H. Slunt, Andrew Doan, T. Ratovitsky, Gopal Thinakaran, Howard Y. Chen, Sangram S. Sisodia, David R. Borchelt, Michael K. Lee, Hui Zheng, F. Davenport, Donald L. Price, Philip C. Wong

Publikováno v: Presenilins and Alzheimer’s Disease ISBN: 9783642721052

Neither the normal functions of presenilins nor the mechanism(s) by which familial Alzheimer’s disease (FAD)-linked mutations cause AD have been defined. Presenilin 1 (PS1) is a polytopic membrane protein that is subject to endoproteolytic processi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4e06cb45b9c72de685e3425ff88d828
https://doi.org/10.1007/978-3-642-72103-8_5

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The APP and PS1/2 Mutations Linked to Early Onset Familial Alzheimer’s Disease Increase the Extracellular Concentration of Aβ1–42(43)

Autor: S. G. Younkin

Publikováno v: Presenilins and Alzheimer’s Disease ISBN: 9783642721052

The amyloid β protein (Aβ) is an ~4 kD secreted protein that is derived from a set of large, alternatively spliced precursor proteins collectively referred to as the amyloid β protein precursor (βAPP). Secreted Aβ is readily detected in cerebros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a94e4468eae720c8d780e3af312da891
https://doi.org/10.1007/978-3-642-72103-8_4

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Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

Autor: R S, Turner, N, Suzuki, A S, Chyung, S G, Younkin, V M, Lee

Publikováno v: The Journal of biological chemistry. 271(15)

Previous studies have demonstrated the presence of amyloid beta (Abeta) in neurons (NT2N) derived from a human embryonal carcinoma cell line (NT2) by steady state metabolic radiolabeling and immunoprecipitation. We show here that Abeta is present int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0894d3bb04e5578097dbb39be8cc3a9
https://pubmed.ncbi.nlm.nih.gov/8621541

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Amyloid beta protein (A beta) removal by neuroglial cells in culture

Autor: L M, Shaffer, M D, Dority, R, Gupta-Bansal, R C, Frederickson, S G, Younkin, K R, Brunden

Publikováno v: Neurobiology of aging. 16(5)

Because the mechanisms of A beta degradation in normal and Alzheimer's disease brain are poorly understood, we have examined whether various cortical cells are capable of processing this peptide. Rat microglia and astrocytes, as well as the human THP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::93f59903731c614cbb5566ed3af39517
https://pubmed.ncbi.nlm.nih.gov/8532106

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Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)

Autor: S A, Gravina, L, Ho, C B, Eckman, K E, Long, L, Otvos, L H, Younkin, N, Suzuki, S G, Younkin

Publikováno v: The Journal of biological chemistry. 270(13)

Biochemical and immunocytochemical analyses were performed to evaluate the composition of the amyloid beta protein (A beta) deposited in the brains of patients with Alzheimer's disease (AD). To quantitate all A beta s present, cerebral cortex was hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9f6e3efca09855ef02f31989d64f431
https://pubmed.ncbi.nlm.nih.gov/7706234

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Production of Amyloid β Protein from Normal and Mutated Amyloid β Protein Precursors

Autor: M. Shoji, X.-D. Cai, Todd E. Golde, S. G. Younkin, T.-T. Cheung

Publikováno v: Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease ISBN: 9783662011379

In patients with Alzheimer’s disease (AD), large numbers of senile plaques are found throughout the neuropil of the cerebral neocortex and hippocampus. These senile plaques, which are present in small numbers in the brains of aged mammals and norma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13f3458020f5eab1a735d870920818f1
https://doi.org/10.1007/978-3-662-01135-5_4

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The pathology of ophthalmoplegia in herpes zoster ophthalmicus

Autor: P. J. M. Lavin, S. G. Younkin, S. H. Kori

Publikováno v: Neuro-Ophthalmology. 4:75-80

Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year. An associated finding included a 2+ positive antinuclear antibody test with a titer of 1:320. Optic disc swelling was resolved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a85b0f13bf4e492b8195098b95da1eaf
https://doi.org/10.3109/01658108409053863

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