Zobrazeno 1 - 10
of 81
pro vyhledávání: '"S G, Reed"'
Publikováno v:
The Journal of Immunology. 157:5034-5041
BALB/c mice are highly susceptible to infection with the protozoan parasite Leishmania major. This susceptibility has been attributed, in part, to the expansion of parasite-specific CD4+ Th2 cells that antagonize Th1 responses and promote humoral imm
Autor:
H W Ghalib, J A Whittle, M Kubin, F A Hashim, A M el-Hassan, K H Grabstein, G Trinchieri, S G Reed
Publikováno v:
The Journal of Immunology. 154:4623-4629
IL-12 is a pluripotent cytokine that interacts with NK and T cells to play a central role in the initiation and maintenance of Th1 responses and IFN-gamma production. Because of the interactive relationship between IL-12 and IFN-gamma response to inf
Publikováno v:
The Journal of Immunology. 153:5782-5789
IL-10 has been shown to be capable of down-regulating several aspects of macrophage function. This study was undertaken to define the association between IL-10 and HIV-1 infection in human macrophages. Infection of macrophages with a monocytotropic s
Publikováno v:
The Journal of Immunology. 153:3135-3140
IL-10 has been shown to inhibit some aspects of macrophage activation, including the in vitro IFN-gamma-mediated intracellular killing of the protozoan parasite Trypanosoma cruzi. We have previously shown that genetically susceptible mice produced mo
Publikováno v:
The Journal of Immunology. 152:5949-5956
Visceral leishmaniasis is associated with a marked depression of T cell responses, which has been characterized by the absence of IL-2 and IFN-gamma production by lymphocytes on in vitro stimulation with Leishmania Ag. The aim of this study was to ev
Autor:
W. G. Shreffler, P. R. Sleath, José Mauro Peralta, M. G. M. Teixeira, S. G. Reed, J. B. Pereira, J. M. Burns
Publikováno v:
Journal of Clinical Microbiology. 32:971-974
An enzyme-linked immunosorbent assay (ELISA) was developed for detecting antibodies against Trypanosoma cruzi. Two synthetic T. cruzi peptides, TcD and PEP2, were used. The specificity and sensitivity of the peptide ELISA were determined with 260 ser
Publikováno v:
The Journal of Immunology. 151:5504-5515
We have cloned and characterized cDNA molecules that encode members of the acidic ribosomal protein family (TcP proteins) from the protozoan parasite Trypanosoma cruzi. These proteins have been shown to be antigenic in individuals with T. cruzi infec
Publikováno v:
The Journal of Immunology. 151:3712-3718
The importance of Ag-specific gamma delta T lymphocytes in human immune responses to pathogenic organisms is unknown. In the present study the expression of gamma delta TCR on T lymphocytes from patients with cutaneous, mucosal, or visceral leishmani
Publikováno v:
The Journal of Immunology. 150:916-924
The stimulation of normal human PBMC by Trypanosoma cruzi Ag was analyzed. PBMC showed significant in vitro proliferation in response to parasite lysate (Tct), with stimulation indices ranging from 10 to 400, peaking at 6 to 7 days. The cells stimula
Publikováno v:
The Journal of Immunology. 150:932-939
Both a conserved surface metalloprotease of leishmania, gp63 as well as certain gp63-derived peptides, have been shown to have immunoprophylactic potential in mouse models of leishmaniasis. In addition, PBMC from individuals with cutaneous, mucosal,