Zobrazeno 1 - 10
of 15
pro vyhledávání: '"S G, Nadler"'
Publikováno v:
The Journal of Immunology. 155:2427-2436
Deoxyspergualin (DSG) is a potent immunosuppressive agent that is currently undergoing clinical trials for treatment of transplant rejection, preventive of human anti-mouse Ab response, and blocking autoimmune disease progression. The mechanism of ac
Publikováno v:
Immunobiology. 202(3)
We have shown previously that increased levels of hsp70, and antibodies reactive with hsp70 parallel the onset and severity of graft-versus-host disease (GVHD) in a parent --(DA x LEW)F1 rat model. In this study we have assessed the effect of reducin
Autor:
O K, Haffar, S, Popov, L, Dubrovsky, I, Agostini, H, Tang, T, Pushkarsky, S G, Nadler, M, Bukrinsky
Publikováno v:
Journal of molecular biology. 299(2)
Replication of HIV-1 in non-dividing and slowly proliferating cell populations depends on active import of the viral pre-integration complex (PIC) into the cell nucleus. While it is commonly accepted that this process is mediated by an interaction be
Autor:
S M, Fujihara, S G, Nadler
Publikováno v:
Biochemical pharmacology. 56(2)
Eukaryotic cells depend upon the regulated exchange of proteins and RNA between the cytoplasm and the nucleus for survival. Various cytoplasmic and nuclear proteins play a fundamental role in this specific transport process. Over the last few years t
Publikováno v:
The Journal of biological chemistry. 272(17)
The role of intracellular oxidative stress in the mechanism of action of phosphotyrosine phosphatase (PTP) inhibitors was studied using three vanadium-based compounds. Sodium orthovanadate (Na3VO4), sodium oxodiperoxo(1,10-phenanthroline)vanadate(V)
Publikováno v:
The Journal of biological chemistry. 272(6)
Cross-linking of the Fc receptor (FcR) to surface immunoglobulin (sIg) on B cells inhibits the influx of extracellular calcium and abrogates the proliferative signal. The mechanism by which this occurs is not well understood. In this report we show t
Autor:
J A, Ledbetter, J A, Francisco, C B, Siegall, L K, Gilliland, D, Hollenbaugh, A, Aruffo, A W, Siadak, N, Mischel-Petty, L S, Grosmaire, M L, Gordon, T J, Brown, P, Moran-Davis, R S, Mittler, P A, Kiener, S G, Nadler
Publikováno v:
Critical reviews in immunology. 17(5-6)
A single-chain Fv (sFv) was expressed from the variable regions of the CD40-specific mAb G28-5. The molecule bound CD40 with a high affinity (2.2 nM) and was a monomer in solution. Surprisingly, G28-5 sFv was a potent CD40 agonist that rapidly crossl
Publikováno v:
Transplantation proceedings. 28(2)
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 155(5)
Deoxyspergualin (DSG) is a potent immunosuppressive agent that is currently undergoing clinical trials for treatment of transplant rejection, preventive of human anti-mouse Ab response, and blocking autoimmune disease progression. The mechanism of ac
Autor:
P S, Linsley, S G, Nadler, J, Bajorath, R, Peach, H T, Leung, J, Rogers, J, Bradshaw, M, Stebbins, G, Leytze, W, Brady
Publikováno v:
The Journal of biological chemistry. 270(25)
CD28 and CTLA-4 are homologous T cell receptors of the immunoglobulin (Ig) superfamily, which bind B7 molecules (CD80 and CD86) on antigen-presenting cells and transmit important costimulatory signals during T cell activation. Here we have investigat