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ChemInform Abstract: Synthesis and Complementary Complex Formation Properties of Oligonucleotides Covalently Linked to New Stabilizing Agents

Autor: T. Grandi, Enzo Sottofattori, S. G. Lokhov, Mauro Mazzei, Alexander V. Lebedev, Alessandro Balbi, Tatyana V. Abramova

Publikováno v: ChemInform. 25

Oligodeoxyribonucleotides of different lengths have been prepared and linked to new stabilizing agents related to the coumarin family. These ODNSAs (OligoDeoxyriboNucleotides with Stabilizing Agents) were tested against acridine connected oligomers o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::996346ee835d837872959d5d2b82a723
https://doi.org/10.1002/chin.199433275

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[Interactions of derivatives of short oligonucleotides with nucleic acids. VII. Effect of conformation changes in the duplex structure on on the specificity and efficacy of modification of target DNA by alkylating oligonucleotide derivatives]

Autor: D V, Pyshnyĭ, S G, Lokhov, E M, Ivanova, V F, Zarytova

Publikováno v: Bioorganicheskaia khimiia. 24(2)

The modification of a target DNA by alkylating oligonucleotide derivatives possessing various capacities for complex formation was studied. The binding properties of oligonucleotides were changed either by increasing their length (tetra-, octa-, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a98995788482090fc7bd2bcea12b546
https://pubmed.ncbi.nlm.nih.gov/10335409

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[Interaction of derivatives of short oligonucleotides with nucleic acids. VIII. Characteristics of target DNA modification by alkylating oligonucleotide derivatives in tandem complexes]

Autor: D V, Pyshnyĭ, S G, Lokhov, E M, Ivanova, V F, Zarytova

Publikováno v: Bioorganicheskaia khimiia. 24(3)

The influence of effectors [octanucleotides and their 3',5'-di-N-(2-hydroxyethyl)phenazinium derivatives] on the modification of a target DNA by alkylating oligonucleotide derivatives forming duplexes of different stability with the target ws studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc154db5af0d269e891ee2f28bd2861b
https://pubmed.ncbi.nlm.nih.gov/9612562

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[Interaction of short oligonucleotides derivatives with nucleic acids. VI. Discrimination of mismatch-containing complexes upon ligation of a short oligonucleotide tandem on DNA template]

Autor: D V, Pyshnyĭ, A A, Krivenko, S G, Lokhov, E M, Ivanova, G M, Dymshits, V F, Zarytova

Publikováno v: Bioorganicheskaia khimiia. 24(1)

The high ligation specificity of a tetranucleotide with a pair of flanking octanucleotides on DNA template by the action of T4 phage DNA ligase is shown. In a tetranucleotide-DNA template complex containing a mismatch, almost no ligation products are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9a3e6d15778f597fd614350518d34a0
https://pubmed.ncbi.nlm.nih.gov/9551199

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[Interaction of short oligonucleotide derivatives with nucleic acids. V. Ligation of short oligonucleotides in tandem on a complimentary DNA template]

Autor: D V, Pyshnyĭ, A A, Krivenko, S G, Lokhov, E M, Ivanova, G M, Dymshits, V F, Zarytova

Publikováno v: Bioorganicheskaia khimiia. 24(1)

A tetranucleotide was highly specifically and quantitatively ligated with a pair of flanking octanucleotides carrying both radioactive and nonradioactive reporter groups. The sequence of the ligation of oligonucleotide components in a tandem on a com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b85f1acdf9cfd2f31860d18b77f6edd
https://pubmed.ncbi.nlm.nih.gov/9551198

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[Interaction of short nucleotide derivatives with nucleic acids. IV. Modification of DNA by an alkylating tetranucleotide reagents in the presence of effectors in perfect and imperfect complexes]

Autor: D V, Pyshnyĭ, I A, Pyshnaia, S G, Lokhov, E M, Ivanova, V F, Zarytova

Publikováno v: Bioorganicheskaia khimiia. 23(11)

It was demonstrated that any mismatches in a complex formed by an ssDNA target and a tetranucleotide at 25 or 37 degrees C can be discriminated by alkylating the DNA with a tetranucleotide carrying a 4-[N-methyl-N-(2-chloroethyl)]aminobenzylethylamin

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https://pubmed.ncbi.nlm.nih.gov/9518430

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Modulation of Cm/T, G/A, and G/T triplex stability by conjugate groups in the presence and absence of KCl

Autor: H B, Gamper, I V, Kutyavin, R L, Rhinehart, S G, Lokhov, M W, Reed, R B, Meyer

Publikováno v: Biochemistry. 36(48)

Apparent equilibrium association constants were determined by gel mobility shift analysis for triple strand formation between a duplex target containing a 21 base long A-rich homopurine run and several end-modified C(m)/T (pyrimidine motif; C(m) = 5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::389185a5c0a2ecfa671f76d78dbb3396
https://pubmed.ncbi.nlm.nih.gov/9398203

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[Selective stabilization of AT-rich DNA duplexes by oligodeoxyribonucleotide conjugates with distamycin analogues]

Autor: A N, Siniakov, V A, Riabinin, S V, Seregin, S G, Lokhov, I V, Kutiavin, H B, Gamper, R B, Mayer

Publikováno v: Bioorganicheskaia khimiia. 23(7)

Oligodeoxyribonucleotide conjugates with distamycin analogues containing up to five pyrrolecarboxamide moieties were synthesized. The stability of duplexes formed by these conjugates was shown to depend directly upon the number of pyrrolecarboxamide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7c2f0fa3bf52a3d4888647e9d163439
https://pubmed.ncbi.nlm.nih.gov/9471974

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[Nucleic acids interactions with short oligonucleotide derivatives. II. Tandem of short oligonucleotides as highly sensitive system for identification of single base substitutions in target DNA]

Autor: D V, Pyshnyĭ, M A, Podyminogin, I A, Pyshnaia, S G, Lokhov, E M, Ivanova, V F, Zarytova

Publikováno v: Bioorganicheskaia khimiia. 23(7)

A new approach for modification of target DNAs with tandems of derivatives of short oligonucleotides was suggested that allows highly selective modification of perfect duplexes only. At physiological temperatures, the efficiency of DNA modification b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9ecdd0164dd1007b285642a8972df7c
https://pubmed.ncbi.nlm.nih.gov/9471976

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[Artificial ribonucleases I. Targeted RNA cleavage by 5'-peptidyloligodeoxyribonucleotides containing arginine and leucine residues]

Autor: D V, Pyshny'i, M N, Repkova, S G, Lokhov, E M, Ivanova, A G, Ven'iaminova, V F, Zarytova

Publikováno v: Bioorganicheskaia khimiia. 23(6)

The interaction of DNA and RNA with oligodeoxyribonucleotides and their 3'-terminal N-(2-hydroxyethyl)phenazinium derivatives carrying peptide residues with alternating basic and hydrophobic amino acids at the 5'-terminal phosphate was studied. It wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be57c7603d1da18d9e8b01569342ac14
https://pubmed.ncbi.nlm.nih.gov/9265472

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