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Autor:
S G, Hymowitz, H W, Christinger, G, Fuh, M, Ultsch, M, O'Connell, R F, Kelley, A, Ashkenazi, A M, de Vos
Publikováno v:
Molecular cell. 4(4)
Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4 and DR5, triggers apoptosis by inducing the oligomerization of intracellular death domains. We report the crystal structure of the complex between Apo2L and the