Zobrazeno 1 - 10
of 2 832
pro vyhledávání: '"S Fraser"'
Publikováno v:
Aquaculture Environment Interactions, Vol 15, Pp 251-269 (2023)
Fish farm waste dispersal models are widely used but have only been directly validated to a limited extent. Two shallow (
Externí odkaz:
https://doaj.org/article/ce75d9f6326e45c4a66129997ad1a1c1
Autor:
Cameron S. Fraser, Johan K. E. Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N. Hata, Jeffrey W. Miller, Gary A. Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek, Kristopher A. Sarosiek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al. show that BH3 mimetics, which inhibit pro-survival proteins BCL-2 or MCL-
Externí odkaz:
https://doaj.org/article/af565676a38f48089f10fb446aad1c14
Autor:
D.-Yin Lin, Brigid Brown, Craig Morrison, Nikolai S. Fraser, Cheryl S. L. Chooi, Matthew G. Cehic, David H. McLeod, Michael D. Henningsen, Nikolina Sladojevic, Hidde M. Kroon, Ruurd L. Jaarsma
Publikováno v:
BMC Anesthesiology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background The PEricapsular Nerve Group (PENG) block is a novel regional analgesia technique that provides improved analgesia in patients undergoing hip surgery while preserving motor function. In this study the PENG block was investigated f
Externí odkaz:
https://doaj.org/article/c853886f07d74dfa977560de20d8c544
Autor:
Carole Fogg, Simon D. S. Fraser, Paul Roderick, Simon de Lusignan, Andrew Clegg, Sally Brailsford, Abigail Barkham, Harnish P. Patel, Vivienne Windle, Scott Harris, Shihua Zhu, Tracey England, Dave Evenden, Francesca Lambert, Bronagh Walsh, The Frailty Dynamics study team
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Frailty is a common condition in older adults and has a major impact on patient outcomes and service use. Information on the prevalence in middle-aged adults and the patterns of progression of frailty at an individual and populati
Externí odkaz:
https://doaj.org/article/caa89d90bd8f4921bb3ad6937470b23d
Autor:
Bianca A. Schuster, Dagmar S. Fraser, Jasper J. F. van den Bosch, Sophie Sowden, Andrew S. Gordon, Dongsung Huh, Jennifer L. Cook
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The ability to ascribe mental states, such as beliefs or desires to oneself and other individuals forms an integral part of everyday social interaction. Animations tasks, in which observers watch videos of interacting triangles, have been ex
Externí odkaz:
https://doaj.org/article/18e5a620ff264e908a8bf4816eb586b3
Autor:
Kinda Ibrahim, Natalie J. Cox, Jennifer M. Stevenson, Stephen Lim, Simon D. S. Fraser, Helen C. Roberts
Publikováno v:
BMC Geriatrics, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract Background Older people living with frailty are often exposed to polypharmacy and potential harm from medications. Targeted deprescribing in this population represents an important component of optimizing medication. This systematic review a
Externí odkaz:
https://doaj.org/article/b35a16a9578f4e88bf462275c22ab5ba
Autor:
Stephanie A Wankowicz, Saulo H de Oliveira, Daniel W Hogan, Henry van den Bedem, James S Fraser
Publikováno v:
eLife, Vol 11 (2022)
While protein conformational heterogeneity plays an important role in many aspects of biological function, including ligand binding, its impact has been difficult to quantify. Macromolecular X-ray diffraction is commonly interpreted with a static str
Externí odkaz:
https://doaj.org/article/42e8ec0d84fa4d86ba8fa90a81eae627
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
Autor:
Aron Broom, Rojo V. Rakotoharisoa, Michael C. Thompson, Niayesh Zarifi, Erin Nguyen, Nurzhan Mukhametzhanov, Lin Liu, James S. Fraser, Roberto A. Chica
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Kemp eliminases are artificial enzymes that catalyze the concerted deprotonation and ring-opening of benzisoxazoles. Here, the authors use room-temperature X-ray crystallography to investigate changes to the conformational ensemble of the Kemp elimin
Externí odkaz:
https://doaj.org/article/7439f4de0efc41d198a2176b909a8ff0
Autor:
Jimmy M. Hsu, Aaron Hass, Marc-Alexandre Gingras, Jaron Chong, Cecilia Costiniuk, Nicole Ezer, Richard S. Fraser, Emily G. McDonald, Todd C. Lee
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-5 (2020)
Abstract Background Pneumocystis jirovecii pneumonia (PJP) can be challenging to diagnose, often requiring bronchoscopy. Since most patients suspected of PJP undergo imaging, we hypothesized that the findings of these studies could help estimate the
Externí odkaz:
https://doaj.org/article/47f9dfb4e1c14879944e69c9ba3c745b
Autor:
Hilda O. Hounkpatin, Simon D. S. Fraser, Rory Honney, Gavin Dreyer, Alison Brettle, Paul J. Roderick
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background There are a growing number of studies on ethnic differences in progression and mortality for pre-dialysis chronic kidney disease (CKD), but this literature has yet to be synthesised, particularly for studies on mortality. Methods
Externí odkaz:
https://doaj.org/article/0351ebba197f4001b8512a7f74796507